Last Updated Dec 15, 2022, 8:00 PM

San Francisco 49ers vs. Seattle Seahawks Picks, Predictions, Odds

Week 15 of the NFL season will kick things off with a compelling NFC West showdown between the San Francisco 49ers and Seattle Seahawks. Coverage begins from Lumen Field in Seattle at 8:15 p.m. ET on Amazon Prime.


Figuring out the Seahawks has been an incredibly daunting task throughout the season, as Seattle appeared to be dead in the water after averaging just 15.7 PPG across an ugly 1-2 start to the year. 

However, to the majority’s surprise, Geno Smith and co. came charging back with wins in five of their next six contests, quickly stealing the hearts of fans by generating 32.3 PPG on the offensive side of the ball during that stretch.

But unfortunately, Seattle’s offense has cooled off as of late, and when they aren’t lighting up the scoreboard for over 30 PPG, it’s really tough for Pete Carroll’s squad to grind out wins behind their lackluster defensive unit, as the Seahawks have now posted losses in three of their last four games, primarily due to their defense surrendering over 28 PPG in those contests.

While on the other hand, the 49ers are just an excellent football team from top-to-bottom, and they continue to prove it week after week, as San Francisco enters Thursday riding an impressive six-game win streak that includes tough victories over the Chargers, Dolphins, Bucs, and Cardinals.

You would think Jimmy Garoppolo breaking his foot in the middle of a big Week 13 matchup against the Dolphins might derail the operation for at least a few minutes. But that couldn’t be further from the case for this squad, as San Francisco has actually played some of its best football of the season since Garoppolo’s injury, highlighted by the Niners racking up a lofty average of 34 PPG in their latest two affairs with rookie Brock Purdy under center.

I’m not quite sure what the future holds for this San Francisco squad. But if there’s one thing that’s generally accepted about the Niners, it’s that their defense is phenomenal. So, the sky is the limit for them if Purdy can continue this level of production on the other side of the script.

I’ll back the Niners here, as they held the Seahawks to just 216 total yards and forced three turnovers in a 27-7 rout in their first meeting of the year back in Week 2. And while Seattle’s offense has certainly come a long way since that matchup, I still expect them to find a limited amount of success against a Niners’ defense that’s surrendered less than 20 PTS in 11-of-13 contests this season (15.2 PPG).

Score Prediction: Niners 27, Seahawks 20
Best Bet: Niners -3.5 (-105)


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Date: Thursday, December 15, 2022
Matchup: NFC West
Venue: Lumen Field
Location: Seattle, Washington
Time-TV: Amazon Prime, 8:15 p.m. ET


The Niners stumbled out to a surprisingly mediocre 3-4 start to the season, however, the Kyle Shanahan train appears to be full steam ahead heading into Week 15, as San Francisco enters Thursday following wins in six straight contests, primarily thanks to a defense that ranks first in the league in both scoring and total yardage on the year (15.2 PPG, 287 YPG).

For a while, I’ve joked that pretty much anybody could be a successful signal caller for this San Francisco squad with their plethora of offensive weaponry and such a great defense. 

But they’ve actually pushed the envelope on that notion the last few weeks with Purdy now thriving at the helm for them, highlighted by the 262nd pick of last year’s draft leading the Niners’ offense to 34 PPG while completing 67% of his passes for roughly 200 YPG and a four-to-one TD-to-INT ratio the last two weeks.

Regardless of who’s under center, the Niners can stand toe-to-toe with pretty much any team in the league behind their top-ranked defense. However, if they continue building momentum on the offensive side of the ball with Purdy, San Francisco could easily wind up being the most feared squad in the league heading into the postseason.

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The Niners are 3-15 SU in their last 18 matchups against Seattle. (Getty)


The Seahawks have become very popular amongst the mainstream betting audience, and rightfully so, as the oddsmakers quickly wrote off Seattle after posting ugly losses in two-of-three contests out of the gate. 

But then, they stormed back averaging over 30 PPG across their next six contests, cashing boatloads of heavy moneyline underdog tickets with a stunning 5-1 run. And for a brief moment, everybody seemed to forget the abysmal performance of Seattle’s defense thus far.

However, I think it’s safe to say that we’ve all been reminded, as the Seahawks now enter Thursday following losses in three of their last four games, while averaging a modest 25 PPG on the offensive side of the ball in those contests. But it still hasn’t quite been enough to overcome their defense surrendering 28.5 PPG during their latest stretch.

So, good luck trying to slow down a Niners squad that’s scored 32+ PTS in two straight matchups against far superior defensive units in the Bucs and Dolphins.


  • The Niners are 5-1 ATS in their last six games.
  • The total has gone OVER in five of San Francisco's last seven games.
  • The Niners are 6-0 SU in their last six games.
  • The Seahawks are 1-4 ATS in their last five games.
  • The total has gone OVER in four of Seattle's last five games.
  • The total has gone OVER in six of Seattle's last nine games against San Francisco.
  • The total has gone OVER in six of Seattle's last nine home games.
  • The Niners are 6-14 ATS in their last 20 matchups against Seattle.
  • The Niners are 3-15 SU in their last 18 games against Seattle.
  • The Niners are 7-3 ATS in their last 10 road games.
  • The Niners are 1-10 SU in their last 11 road games against Seattle.
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