49ERS Odds: Schedule, Matchups, & Stats
49ers injuries
| Pos | Player | Status |
|---|
49ers Schedule
| Date | Opp | Close | Result | ATS/OU |
|---|---|---|---|---|
| Sep 7, 2025 | @Seahawks | - / | 4:05 PM ET | |
| Sep 14, 2025 | @Saints | - / | 1:00 PM ET | |
| Sep 21, 2025 | Cardinals | - / | 4:25 PM ET | |
| Sep 28, 2025 | Jaguars | - / | 4:05 PM ET | |
| Oct 2, 2025 | @Rams | - / | 8:15 PM ET | |
| Oct 12, 2025 | @Buccaneers | - / | 1:00 PM ET | |
| Oct 19, 2025 | Falcons | - / | 8:20 PM ET | |
| Oct 26, 2025 | @Texans | - / | 1:00 PM ET | |
| Nov 2, 2025 | @Giants | - / | 3:00 PM ET | |
| Nov 9, 2025 | Rams | - / | 6:25 PM ET | |
| Nov 16, 2025 | @Cardinals | - / | 6:05 PM ET | |
| Nov 24, 2025 | Panthers | - / | 10:15 PM ET | |
| Nov 30, 2025 | @Browns | - / | 3:00 PM ET | |
| Dec 14, 2025 | Titans | - / | 6:25 PM ET | |
| Dec 22, 2025 | @Colts | - / | 10:15 PM ET | |
| Dec 28, 2025 | Bears | - / | 10:20 PM ET | |
| Jan 4, 2026 | Seahawks | - / | 3:00 PM ET |
Betting on the San Francisco 49ers
The San Francisco 49ers are not just one of the most famous professional football teams, but professional sports teams overall. With many notable players and a long history filled with wins, the 49ers have a loyal following and a huge fanbase. So, many people want to place their bets on this team, and this guide will help with your San Francisco 49ers betting.
The San Francisco 49ers, named for the prospectors in the 1849 Gold Rush who came to Northern California, compete in the National Football League in the West Division as a member of the National Football Conference. The team plays its home games in Santa Clara, CA at Levi’s Stadium. The 49ers have been around since 1946, when they were founded as a charter member of the All-America Football Conference.
The All-America Football Conference merged with the NFL, which is why the 49ers joined the NFL in 1949. The franchise is the tenth oldest team in the NFL. The team is San Francisco’s first major league professional sports franchise.
The 49ers have had one of the best records of any NFL team. They won five Super Bowl championships between the years 1981 and 1994. Between 1970 and 2021, the team were the division champions twenty one times.
The team has reached the league playoffs an impressive twenty eight times, and the 49ers hold the record for playing in the most NFC Championship games. The 49ers are usually ranked as one of the richest sports franchises in the world.
Some famous players who have been on the 49ers are Joe Montana, Jerry Rice, Ronnie Lott, Steve Young, Charles Haley, and Fred Dean.
The 49ers have had a few notable rivalries: the Los Angeles Rams and the 49ers have a rivalry that was listed as number 8 in Sports Illustrated’s “Top 10 NFL Rivalries of All Time” list. The Seattle Seahawks are a relatively newer rival for the 49ers. Other notable rivals have been: the Arizona Cardinals, Green Bay Packers, Dallas Cowboys, New York Giants, Atlanta Falcons, Las Vegas Raiders, and Cleveland Browns.
A bet made often on NFL games is a moneyline bet. A moneyline bet is looking to choose the victor of any given match. Here you will see what a moneyline bet typically looks like:
- San Francisco 49ers: -102
- Los Angeles Rams: +102
With this example, the team that is more likely to win is the San Francisco 49ers because of the odds of -102. This means for every $1 the wagerer is looking to earn, they would need to bet $1.02, to bet $102 to earn $100. The franchise that is the less likely to win in this game is the Los Angeles Rams according to the odds of +102. This means for every $1 bet, the wagerer could earn $1.02, to bet $100 to gain $102.
At VegasInsider, we have the latest San Francisco 49ers odds and a ton of expert information and picks to aid you with your betting! If you want to get the best bet for your money, we make sure to keep odds updated for the latest SF 49ers stats so that you can have the most accurate information at your disposal.
Betting in California
As of right now, California does not have any form of legal sports betting. It is not legal to place sports bets either in-person or online in the state of California. However, California sports betting has many supporters, so that may change in the future.
For the time being, sports fans in California can play daily fantasy sports (DFS) or at social sportsbooks like Fliff, Thrillzz, and Rebet.
San Francisco 49ers Partnership with Sportsbook
As of this time, the San Francisco 49ers do not have a partnership with a sportsbook. However, they have partnered with Cache Creek Casino Resort and the Yocha Dehe Wintun Nation. So, once California sports betting is legalized, that is expected to change.
