2025 College Football Odds Week 10: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

5 minute read

The College Football Odds Week 10 market includes a matchup that, earlier this season, many thought would be among the Games of the Year: Penn State vs. Ohio State.

Now, not so much. But it's still key for the Buckeyes, no question. More notable in college football Week 10 odds: Vanderbilt vs. Texas and Cincinnati vs. Utah, among others.

Here’s everything you need to know about college football odds Week 10: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 10 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Steve Roberts/Imagn Images)

2025 College Football Odds for Week 10

Vanderbilt vs. Texas Odds

• Opening point spread: Texas -3
• Opening moneyline: Texas TBA/Vanderbilt TBA
• Opening total: Over/Under 45.5 points scored
• Time: Noon ET Saturday (TV TBA)

OPENING ODDS UPDATE: Vanderbilt (7-1 SU/6-2 ATS) continued its surprising season with a barely-got-there Week 9 win. The Commodores topped Missouri 17-10 as 3-point home favorites, stopping a Hail Mary on the 1-yard line to dodge overtime or a potential loss.

Texas (6-2 SU/2-6 ATS) nearly saw its season evaporate, trailing by 17 three times in the second half at Mississippi State, twice in the fourth quarter. But the Longhorns rallied for a 45-38 overtime victory laying 8 points on the road.

Arch Manning suffered a concussion on the first play of OT, so his Week 10 status is unclear at the moment.

Still, Texas opened as a 3-point home favorite in Circa's college football Week 10 odds. That line was a quick mover, too, nudging to Longhorns -2.5 within minutes Sunday.

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Penn State vs. Ohio State Odds

• Opening point spread: Ohio State -20
• Opening moneyline: Ohio State TBA/Penn State TBA
• Opening total: Over/Under 43.5 points scored
• Time: Noon ET Saturday (FOX)

OPENING ODDS UPDATE: Ohio State (7-0 SU/6-1 ATS) remains ranked No. 1 and is coming off a Week 9 bye. In Week 8, the Buckeyes blanked Wisconsin 34-0 laying 24.5 points on the road for their fourth straight spread-cover.

On the flip side, Penn State (3-4 SU/1-6 ATS) has been approved for federal disaster relief funds. It all began with a respectable 30-24 home overtime loss to Oregon in Week 5.

Now, the Nittany Lions are on a four-game purge, during which coach James Franklin was fired. Most recently, Penn State suffered a 25-24 setback at Iowa as 3-point Week 8 underdogs. Like Ohio State, Penn State had a bye in Week 9.

Circa Sports, whose opening numbers often draw early sharp play, pegged Ohio State 20-point home chalk to start. The Buckeyes quickly advanced to -21 by 1:40 p.m. ET Sunday, and the line remains there in the college football odds Week 10 market.

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Georgia vs. Florida Odds

• Opening point spread: Georgia -8
• Opening moneyline: Georgia TBA/Florida TBA
• Opening total: Over/Under 50.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC

OPENING ODDS UPDATE: With Florida playing sub-.500 ball, this matchup lacks its usual allure. Still, it's the World's Largest Outdoor Cocktail Party, on neutral turf in Jacksonville, and the Gators would love nothing more than to upset their archrival.

Georgia (6-1 SU/3-4 ATS) had a bye in Week 9 after a big Week 8 victory. The Bulldogs knocked off previously unbeaten Ole Miss 43-35 as 7-point home favorites.

Florida (3-4 SU/2-5 ATS) is also coming off a bye after nearly enduring a home upset vs. Mississippi State. The Gators held on for a 23-21 victory giving 9.5 points. Even with the win, Florida athletic director Scott Stricklin had seen enough this season, firing coach Billy Napier.

Georgia opened -8 in Circa's Week 10 college football odds. That number lasted a short time before dipping to Bulldogs -7.5.

Virginia vs. California Odds

• Opening point spread: Virginia -3
• Opening moneyline: Virginia TBA/California TBA
• Opening total: Over/Under 54.5 points scored
• Time: 3:45 p.m. ET Saturday (ESPN2)

OPENING ODDS UPDATE: At this stage, with the first round of College Football Playoff rankings due out Nov. 4, this report has to include an ACC game. And this one is the best of the Week 10 batch.

Virginia (7-1 SU/5-3 ATS) has somewhat flown under the radar this season, currently on a six-game SU win streak that includes three overtime victories. In Week 9, the Cavaliers edged North Carolina 17-16 by stopping a 2-point attempt in the first overtime.

However, the Cavs fell well short of cashing as 11.5-point road favorites.

California is 5-3 SU (3-5 ATS) but could just as easily be 6-2 SU at this point. In Week 9, the Golden Bears got a late touchdown at Virginia Tech to tie the game at 27 and force overtime. But Cal fell 42-34 in double overtime as a 6.5-point underdog.

Circa Sports opened Virginia -3 in the college football odds Week 10 market. Shortly thereafter Sunday, the Cavaliers advanced to -3.5.

Oklahoma vs. Tennessee Odds

• Opening point spread: Tennessee -3
• Opening moneyline: Tennessee TBA/Oklahoma TBA
• Opening total: Over/Under 56.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: Tennessee (6-2 SU/4-4 ATS) rebounded nicely from its Week 8 loss at Alabama. The Vols pounded Kentucky 56-34 as 7.5-point road favorites.

On the flip side, Oklahoma (6-2 SU/4-4 ATS) lost for the second time in three games. The Sooners closed as 5.5-point home favorites vs. Ole Miss and lost 34-26.

Neither team can afford another SEC loss. Circa Sports opened the Vols -3 and sped to -4.5, then settled at -3.5 by 1:35 p.m. ET Sunday. The total was also a quick mover, from 56.5 down to 55.

Cincinnati vs. Utah Odds

• Opening point spread: Utah -7
• Opening moneyline: Utah TBA/Cincinnati
• Opening total: Over/Under 55.5 points scored
• Time: 10:15 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: No. 17 Cincinnati (7-1 SU/6-2 ATS) looks to stay in the chase for the Big 12 title and a bid in the CFP. In Week 9, the Bearcats rolled over Baylor 41-20 as 3.5-point home favorites.

No. 24 Utah (6-2 SU and ATS) also still harbors Big 12 championship aspirations, but can't take another loss. In Week 9, the Utes tuned up by plastering Colorado 53-7 as 14-point home faves.

Utah opened as 7-point home chalk in Circa Sports' college football Week 10 odds. There's been no movement in the first few hours Sunday.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson