College Football Odds Week 4: Colorado vs Oregon Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
Oregon vs
-21.5 (-110)
+21.5 (-110)
o70.5 (-110)
u70.5 (-110)

Week 4 college football odds are here, and we're primed and ready to delve into all of the essential narratives of the upcoming weekend. That includes Colorado vs. Oregon, in a clash of Pac-12 unbeatens that will certainly test Coach Prime and his Buffaloes.

Here's everything you need to know about college football odds for the Week 4 game between Colorado and Oregon: opening lines, spreads, betting trends and more. Check back regularly for updates.

Colorado vs Oregon Odds

Shilo Sanders and Colorado are significant Week 4 underdogs at Oregon. (Getty)
  • Opening point spread: Oregon -17.5
  • Opening moneyline: Oregon -1000/Colorado +625
  • Opening total: Over/Under 70.5 points scored
  • Time: 3:30 p.m. ET Saturday (ABC)

UPDATE 1:30 P.M. ET SATURDAY: Two hours before kickoff, Oregon is laying 21 points at TwinSpires Sportsbook. The lookahead line last week was Oregon -14, and the game reopened Sunday at -20.

Spread tickets are 5/1-plus and spread money 8/1 on Colorado. And it's even more lopsided on the moneyline, with tickets 8/1 and money 10/1 on Colorado, currently +700.

"It's all Colorado. And Colorado moneyline is a monster liability. Oregon is our biggest need of the weekend," TwinSpires director of retail sports Zachary Lucas said.

The total is down to 70.5 from a 72.5 opener. The Over is getting 67% of tickets, while 59% of money is on the Under.

"Sharp play on Under 72.5," Lucas said.

UPDATE NOON ET FRIDAY: Oregon is a 21-point favorite at Fanatics against Colorado, the trendiest team in the nation by far. Bettors are all over the Buffs, with spread tickets and money in the 9/1 range on Colorado.

The Buffaloes are +615 on the moneyline, and bettors are piling on there, as well. Moneyline tickets are 4/1 and moneyline cash almost 8/1 on Colorado. At Fanatics, Colorado-Oregon has taken the most bets of any of Saturday's college football games.

The total opened at 72.5 and by Thursday was down to 70, where it remains today. Early ticket count is almost even, but 73% of early money is on the Under.

UPDATE 3:30 P.M. ET MONDAY: Colorado is quite fortunate to be sitting 3-0 SU at this juncture. The Buffaloes (2-1 ATS), 23.5-point home favorites against Colorado State, were down 28-17 in the fourth quarter. Colorado needed a final-minute TD/2-point conversion to force overtime, tied at 28.

Coach Prime's troops went on to a 43-35 double-OT win, while thrilling bookmakers by falling miles short of covering.

Oregon is certainly part of what's shaping up to be a loaded Pac-12 this season. The Ducks (3-0 SU and ATS) did as expected in Week 3, punching out Hawaii 55-10 as 38.5-point home favorites.

Lucas said Oregon was -14 on the lookahead line in TwinSpires' college football Week 4 odds market. The Ducks reopened -20 Sunday and are now -20.5. That said, early ticket count is 3/1 and early cash 2.5/1 Buffs.

"It's all Colorado. We're moving with the market and fine with people taking Colorado at +20.5," Lucas said. "Colorado moneyline is currently +700, and that will likely be our biggest liability on Saturday."

The total receded from 72.5 to 71 at TwinSpires, with 66% of tickets on the Over/55% of cash on the Under.

"Sharp play on Under 72.5," Lucas said.

UPDATE 2 P.M. ET SUNDAY: Oddsmakers were thoroughly unimpressed with Colorado needing double overtime to beat Colorado State. As such, BetMGM opened Oregon a healthy 17.5-point favorite this morning.

And that wasn't enough. The Ducks are already up to -19.5 in the college football odds Week 4 market.

Colorado (3-0 SU, 2-1 ATS) was a 23.5-point favorite against its instate rival and had to scramble late in the fourth quarter to forge a 28-28 tie and overtime. The Buffs put up TDs in each extra period and got the 2-point conversion in the second OT, then clinched the 43-35 victory with an interception in the end zone.

Meanwhile, Oregon (3-0 SU and ATS) had zero issues with Hawaii. The Ducks steamrolled to a 55-10 victory laying 38.5 points at home.

With Colorado failing to cover, sportsbooks recouped a ton of money that bettors hauled in on the Buffs in Weeks 1 and 2.

"One of the biggest results we'll see all season. You'd have to think it [killed] a thousand parlays," BetMGM trader Seamus Magee said.

But that noted, Magee fully expects bettors to stay on the Buffs bandwagon.

"I imagine we'll see Colorado bettors back next week against Oregon, getting double digits on the road," he said.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 4 Report containing spreads, lines, and trends for every Top 25 matchup.