College Football Odds Week 4: Ohio State vs Notre Dame Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

College football betting lines for Week 4 have been published, and we'll be exploring all the major storylines that lie ahead for the weekend. The marquee primetime game takes place in South Bend as Notre Dame hooks up with Ohio State on Saturday, September 23 at 7:30 p.m. ET on NBC.

Here's everything you need to know about the college football odds for the Week 4 game between Ohio State vs Notre Dame: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Ohio State vs. Notre Dame Odds

Ohio State looks beat Notre Dame for a second straight season on Saturday. (Getty)
  • Opening point spread: Ohio State -3
  • Opening moneyline: Ohio State -141/Notre Dame +117
  • Opening total: Over/Under 54 points scored
  • Time: 7:30 p.m. ET Saturday (NBC)

UPDATE 12:30 P.M. ET FRIDAY: The Buckeyes spent most of the week at various iterations of -3, which is where Fanatics Sportsbook opened this clash. Ohio State topped out at -3.5 (-115) Monday, but returned to -3 Tuesday.

The Buckeyes are netting 61% of spread bets/67% of spread dollars. And at Fanatics, this matchup is taking the most money of any matchup on the college football odds Week 4 slate.

The total climbed from 54 to 55.5 by Tuesday and hasn't moved since. Tickets and money are almost 2/1 on the Over.

UPDATE 3:30 P.M. ET MONDAY: Ohio State (3-0 SU/2-1 ATS) is about to get its first legit challenge of the season. In Week 3, the Buckeyes boatraced Western Kentucky 63-10 giving 29.5 points at home.

Notre Dame already has four games under its belt, playing in Week 0, and is 4-0 SU/3-1 ATS. The Fighting Irish topped Central Michigan 41-17 as 34.5-point home faves, failing to cash for the first time this season.

Last season in Week 1, Ohio State beat Notre Dame 21-10, while the Irish covered as 17-point road 'dogs.

Multiple sportsbooks posted this game preseason with Ohio State a touchdown favorite. When TwinSpires opened it Sunday, Ohio State was -3 and has since inched to -3.5.

Notre Dame is netting 66% of spread bets, while 57% of spread money is on Ohio State.

"It's early, but it's shaping up to be a Pros vs. Joes game. Pros on Ohio State -3," Lucas said.

The total is down a tick to 53.5, with 65% of tickets on the Over/52% of money on the Under.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 4 Report containing spreads, lines, and trends for every Top 25 matchup.