2025 College Football Odds Week 9: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

4 minute read

The College Football Odds Week 9 market is seemingly like every week this time of year. SEC clashes are the biggest ones on the board.

Texas A&M vs. LSU. Ole Miss vs. Oklahoma. Missouri vs. Vanderbilt. But there are other interesting matchups in college football Week 9 odds, including recent upstart UCLA vs. undefeated Indiana.

Here’s everything you need to know about college football odds Week 9: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 9 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Troy Wayrynen/Imagn Images)

2025 College Football Odds for Week 9

UCLA vs. Indiana Odds

• Opening point spread: Indiana -21
• Opening moneyline: Indiana TBA/UCLA TBA
• Opening total: Over/Under 54.5 points scored
• Time: 9 a.m. ET Saturday (FOX)

OPENING ODDS UPDATE: Indiana (7-0 SU/4-3 ATS) had no letdown after its huge Week 7 win at Oregon. In Week 8, the Hoosiers put up 28 points in the middle two quarters (14 in each) and rolled over Michigan State 38-13, just short of cashing as 26.5-point home chalk.

UCLA (3-4 SU and ATS) wouldn't normal merit mention in this space, with a sub-.500 record. But in Week 6, the Bruins played world beater and shocked Penn State 42-37 as a massive 24-point home underdog, beginning the demise of James Franklin and the Nittany Lions.

Now, UCLA is on a three-game win streak. In Week 8, the Bruins edged Maryland 20-17 on a final-seconds field goal, though they failed to cash as 4-point home favorites.

Still, No. 2 Indiana opened as a hefty 21-point home favorite in Circa Sports' college football Week 9 odds. Circa is widely respected for its opening numbers, which tend to draw sharp action in a hurry.

That was the case here, as that line quickly shot to Hoosiers -24.5 by 1:40 p.m. ET Sunday.

Ole Miss vs. Oklahoma Odds

• Opening point spread: Oklahoma -4
• Opening moneyline: Oklahoma TBA/Ole Miss TBA
• Opening total: Over/Under 53.5 points scored
• Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: No. 8 Ole Miss (6-1 SU/4-3 ATS) was primed to remain unbeaten, holding a 35-26 lead over Georgia late in the third quarter. But the Rebels gave up the final 17 points of the game and lost 43-35 as 7.5-point road underdogs.

No. 13 Oklahoma (6-1 SU/4-3 ATS) bounced back just fine from its Week 7 loss vs. Texas. The Sooners dumped South Carolina 26-7 laying 4.5 points on the road.

Circa Sports opened Ole Miss-Oklahoma at Sooners -4 and quickly went to -5. Thirty minutes later, around 2:15 p.m. ET Sunday, the line settled at -4.5. The total was also on the move early, falling from 53.5 to 51.

South Florida vs. Memphis Odds

• Opening point spread: South Florida -3
• Opening moneyline: South Florida TBA/Memphis TBA
• Opening total: Over/Under 65.5 points scored
• Time: Noon ET Saturday (ESPN2)

OPENING ODDS UPDATE: No. 18 South Florida (6-1 SU and ATS) is the highest-ranked Group of 6 team, meaning its on track for a CFP bid – if it wins the American Athletic Conference. In Week 8, the Bulls hammered Florida Atlantic 48-13 as 20.5-point home favorites

Memphis (6-1 SU) will still have something to say about the AAC title, though it stubbed its toe big-time in Week 8. The Tigers were 23.5-point favorites at UAB and shockingly fell outright 31-24, to a team that fired coach Trent Dilfer last Sunday.

That loss took some luster off what was supposed to be a Week 9 showdown between the AAC's two best teams. South Florida opened as 3-point road chalk in Circa Sports' college football odds Week 9 market.

The first move was to USF -2.5, but the line quickly rebounded to -3, then went to -3.5 by 2:25 p.m. ET Sunday.

Missouri vs. Vanderbilt Odds

• Opening point spread: Vanderbilt -3
• Opening moneyline: Vanderbilt TBA/Missouri TBA
• Opening total: Over/Under 52.5 points scored
• Time: 3:30 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: No. 10 Vanderbilt (6-1 SU/5-2 ATS) kept its name firmly in the College Football Playoff conversation in Week 8. The Commodores were 1.5-point home favorites vs. LSU and won 31-24, behind Heisman candidate QB Diego Pavia.

No. 15 Missouri (6-1 SU/5-2 ATS) barely got out of Auburn with a victory. The Tigers closed as 1.5-point favorites and were stretched to double overtime, winning 23-17 on quarterback Beau Pribula's 3-yard touchdown run.

Circa Sports opened Vandy -3 in its Week 9 college football odds. There was a brief dip to Commodores -2.5, then the line returned to -3 just before 2 p.m. ET Sunday.

Texas A&M vs. LSU Odds

• Opening point spread: Texas A&M -1
• Opening moneyline: Texas A&M TBA/LSU TBA
• Opening total: Over/Under 49.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 3 Texas A&M (7-0 SU/3-4 ATS) barely hung on to its unblemished record in a shootout at Arkansas. The Aggies built double-digit leads multiple times but ultimately eked out a 45-42 victory giving 7.5 points.

No. 20 LSU (5-2 SU/3-4 ATS) saw its climb to the SEC title game and/or the College Football Playoff get much harder in Week 8. The Tigers fell short to Vanderbilt 31-24 catching 1.5 points on the road.

Texas A&M opened as 1-point road chalk in Circa Sports' college football odds Week 9 market. In short order, by 2 p.m. ET Sunday, the Aggies moved out to -2.5. The total nudged from 49.5 to 49.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson