College Football Playoff Quarterfinal Odds: Lines, Spreads, Betting Trends on All Four Games

Patrick Everson Sports Betting Expert

3 minute read

College Football Playoff quarterfinal odds hit the board in earnest, with one matchup set and the others to come.

No. 1 Indiana, which got a first-round bye, will square off against No. 9 Alabama in the Rose Bowl, with the Hoosiers favored in CFP Second Round odds. Still awaiting opponents: No. 2 Ohio State, No. 3 Georgia and No. 4 Texas Tech.

Here’s everything you need to know about the college football odds playoff market: opening lines, spreads and betting trends for all four games, as multiple oddsmakers provide insights on College Football Playoff quarterfinal odds and action.

(Feature image: Kirby Lee/Imagn Images)

2025 College Football Playoff Quarterfinals Odds

Alabama vs. Indiana Odds

• Opening point spread: Indiana -6
• Opening moneyline: Indiana -218/Alabama +180
• Opening total: Over/Under 50.5 points scored
• Time: 4 p.m. ET Thursday, Jan. 1 (ESPN)

OPENING ODDS UPDATE: Alabama (11-3 SU/8-5-1 ATS) dug itself into a 17-0 hole just four minutes into the second quarter at Oklahoma. But the Crimson Tide scored the next 27 points and held on for a 34-24 victory as 1.5-point underdogs Friday night.

Meanwhile, Indiana (13-0 SU/8-5 ATS) was resting at home, in the middle of three weeks off after getting a bye as the No. 1 seed. The Hoosiers last played in the Big Ten Championship Game, edging Ohio State 13-10 as 3.5-point underdogs on Dec. 6.

After 'Bama's big comeback, DraftKings Sportsbook opened Indiana as a 6-point favorite for the Rose Bowl. It didn't take long for that to change, with the Hoosiers quickly going to -6.5 (-115), then getting to -7 (-105) in College Football Playoff quarterfinal odds.

The total was quickly on the move late Friday night, as well, opening at 50.5 and making a stop at 49.5 on the way to 48.5.

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Miami vs. Ohio State Odds

• Opening point spread: Ohio State -8.5
• Opening moneyline: Ohio State -395/Miami +310
• Opening total: Over/Under 43.5 points scored
• Time: 7:30 p.m. ET Wednesday, Dec. 31 (ESPN)

OPENING ODDS UPDATE: Ohio State (12-1 SU/10-2-1 ATS) wasn't just one of the best teams on the field all season, but one of the best at the betting window. The Buckeyes were a nation-leading 10-1-1 ATS entering the Big Ten title game.

But Ohio State got knocked down a peg vs. Indiana, losing 13-10 as a 3.5-point favorite to halt a 7-1 ATS run. Still, Ryan Day's troops got the No. 2 seed and a bye in the CFP.

In the Cotton Bowl, the Buckeyes face No. 10 Miami (11-2 SU/8-5 ATS).

The Hurricanes outlasted No. 7 Texas A&M in a rock fight of a first-round game Saturday. Miami won 10-3 on a late touchdown, followed by a defensive stop on an interception in the end zone. Miami cashed as a 3-point road underdog.

Moments after the Hurricanes' win, DraftKings Sportsbook opened Ohio State as 8.5-point favorites vs. Miami. Within just a few minutes, the Buckeyes advanced to -9.5, while the total dipped from 43.5 to 42.5.

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Tulane/Ole Miss vs. Georgia Odds

• Opening point spread: Georgia TBA
• Opening moneyline: Georgia TBA/Tulane-Ole Miss TBA
• Opening total: Over/Under TBA points scored
• Time: 8 p.m. ET Thursday, Jan. 1 (ESPN)

OPENING ODDS UPDATE: Georgia (12-1 SU/6-7 ATS) has won eight in a row since a 24-21 setback as a 2.5-point home favorite vs. Alabama. The Bulldogs avenged that setback with a 28-7 rout of 'Bama as 1.5-point favorites in the SEC Championship Game.

That allowed Georgia to gain the No. 3 seed and a first-round bye.

In the Sugar Bowl, the Bulldogs meet either No. 11 Tulane (11-2 SU/7-6 ATS) or No. 6 Ole Miss (11-1 SU/7-5 ATS).

DraftKings isn't waiting, making Georgia 6-point chalk vs. Ole Miss in College Football Playoff quarterfinal odds.

James Madison/Oregon vs. Texas Tech Odds

• Opening point spread: TBA
• Opening moneyline: Texas Tech TBA/James Madison-Oregon TBA
• Opening total: Over/Under TBA points scored
• Time: Noon ET Thursday, Jan. 1 (ESPN)

OPENING ODDS UPDATE: Texas Tech (12-1 SU/11-2 ATS) has been stout on the field and nearly as solid for bettors, sporting the best spread-covering mark in the nation. In the Big 12 Championship Game, the Red Raiders thumped BYU 34-7 laying 12.5 points.

With the win, Texas Tech nabbed the No. 4 seed and a bye in the CFP.

In the Orange Bowl, Texas Tech meets either No. 12 James Madison (12-1 SU/8-5 ATS) or No. 5 Oregon (11-1 SU/8-4 ATS).

DraftKings fully expects the Ducks to advance. In fact, Oregon is a 1.5-point favorite vs. Texas Tech in College Football Playoff Second Round odds.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson