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Featured Last Updated Nov 10 2025, 4:19 PM

Duke vs. Virginia: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Duke vs. Virginia: Prediction, Odds, Best Bet

Image Credit: David Butler II-Imagn Images

UVA @ DUKE Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Virginia Cavaliers 339 Virginia
+5.5 -110 +3.5 -115 + +3.5 -110 + +3.5 -115 + +3.5 -115 + +3.5 -115 + +3.5 -110 + +3.5 -115 + +3.5 -115 +3.5 -113 + +6 -108  
Duke Blue Devils 340 Duke
-5.5 -110 -3.5 -105 + -3.5 -110 + -3.5 -105 + -3.5 -105 + -3.5 -115 + -3.5 -110 + -3.5 -115 + -3.5 -105 -3.5 -110 + -6 -112  
Virginia Cavaliers 339 Virginia
o59.5 -110 o28.5 -105 + o28.5 -110 + o28.5 -108 + o28.5 -105 + N/A o30.5 -102 + o28.5 -115 + o29.5 -110 o30.5 -108 + o57.5 -112  
Duke Blue Devils 340 Duke
u59.5 -110 u28.5 -115 + u28.5 -110 + u28.5 -112 + u28.5 -115 + N/A u30.5 -120 + u28.5 -115 + u29.5 -110 u30.5 -121 + u57.5 -108  
Virginia Cavaliers 339 Virginia
+195 +160 + N/A +160 + +158 + +150 + +154 + N/A N/A +140 + +195  
Duke Blue Devils 340 Duke
-238 -190 + N/A -185 + -190 + -200 + -192 + N/A N/A -186 + -245  
Virginia Cavaliers 339 Virginia
+5.5 -110 N/A N/A +3.5 -118 + +2.5 -105 + N/A N/A N/A N/A N/A +6 -108  
Duke Blue Devils 340 Duke
-5.5 -110 N/A N/A -3.5 -102 + -2.5 -115 + N/A N/A N/A N/A N/A -6 -112  
Virginia Cavaliers 339 Virginia
o59.5 -110 N/A N/A o28.5 even + o27.5 -120 + N/A N/A o27.5 -125 + N/A N/A o57.5 -112  
Duke Blue Devils 340 Duke
u59.5 -110 N/A N/A u28.5 -120 + u27.5 even + N/A N/A u27.5 -105 + N/A N/A u57.5 -108  
Virginia Cavaliers 339 Virginia
+195 N/A N/A +154 + N/A N/A N/A N/A N/A N/A +195  
Duke Blue Devils 340 Duke
-238 N/A N/A -185 + N/A N/A N/A N/A N/A N/A -245  
Virginia Cavaliers 339 Virginia
+5.5 -110 +3 -125 + N/A +2.5 -110 + N/A N/A +1.5 -128 + +0.5 -110 + +2.5 -110 +1.5 -130 + +6 -108  
Duke Blue Devils 340 Duke
-5.5 -110 -3 -105 + N/A -2.5 -120 + N/A N/A -1.5 +102 + -0.5 -115 + -2.5 -120 -1.5 even + -6 -112  
Virginia Cavaliers 339 Virginia
o59.5 -110 o13 -120 + N/A o12.5 -115 + N/A N/A o13.5 -128 + o13.5 -105 + o13.5 -105 o13.5 -110 + o57.5 -112  
Duke Blue Devils 340 Duke
u59.5 -110 u13 -110 + N/A u12.5 -115 + N/A N/A u13.5 +102 + u13.5 -120 + u13.5 -125 u13.5 -118 + u57.5 -108  
Virginia Cavaliers 339 Virginia
+195 +145 + N/A +145 + +150 + N/A +136 + N/A N/A +125 + +195  
Duke Blue Devils 340 Duke
-238 -180 + N/A -188 + -180 + N/A -174 + N/A N/A -162 + -245  
Virginia Cavaliers 339 Virginia
+5.5 -110 N/A N/A +0.5 -130 + N/A N/A +2.5 -112 + N/A N/A N/A +6 -108  
Duke Blue Devils 340 Duke
-5.5 -110 N/A N/A -0.5 even + N/A N/A -2.5 -118 + N/A N/A N/A -6 -112  
Virginia Cavaliers 339 Virginia
o59.5 -110 o15.5 -110 + N/A o16.5 -140 + N/A N/A o16.5 -130 + N/A N/A N/A o57.5 -112  
Duke Blue Devils 340 Duke
u59.5 -110 u15.5 -110 + N/A u16.5 +110 + N/A N/A u16.5 +104 + N/A N/A N/A u57.5 -108  
Virginia Cavaliers 339 Virginia
+195 +150 + N/A +105 + N/A N/A +140 + N/A N/A N/A +195  
Duke Blue Devils 340 Duke
-238 -180 + N/A -135 + N/A N/A -180 + N/A N/A N/A -245  
Virginia Cavaliers 339 Virginia
+5.5 -110 N/A N/A +0.5 -110 + N/A N/A +1.5 -136 + N/A N/A N/A +6 -108  
Duke Blue Devils 340 Duke
-5.5 -110 N/A N/A -0.5 -120 + N/A N/A -1.5 +102 + N/A N/A N/A -6 -112  
Virginia Cavaliers 339 Virginia
o59.5 -110 o13.5 -115 + N/A o13.5 -125 + N/A N/A o13.5 -110 + N/A N/A N/A o57.5 -112  
Duke Blue Devils 340 Duke
u59.5 -110 u13.5 -105 + N/A u13.5 -105 + N/A N/A u13.5 -114 + N/A N/A N/A u57.5 -108  
Virginia Cavaliers 339 Virginia
+195 +130 + N/A +140 + N/A N/A +134 + N/A N/A N/A +195  
Duke Blue Devils 340 Duke
-238 -155 + N/A -180 + N/A N/A -172 + N/A N/A N/A -245  
Virginia Cavaliers 339 Virginia
+5.5 -110 +0.5 -125 + N/A +0.5 -115 + N/A N/A +1.5 -140 + N/A N/A N/A +6 -108  
Duke Blue Devils 340 Duke
-5.5 -110 -0.5 +105 + N/A -0.5 -115 + N/A N/A -1.5 +106 + N/A N/A N/A -6 -112  
Virginia Cavaliers 339 Virginia
o59.5 -110 o15.5 -110 + N/A o14.5 -110 + N/A N/A o14.5 +106 + N/A N/A N/A o57.5 -112  
Duke Blue Devils 340 Duke
u59.5 -110 u15.5 -110 + N/A u14.5 -120 + N/A N/A u14.5 -132 + N/A N/A N/A u57.5 -108  
Virginia Cavaliers 339 Virginia
+195 +120 + N/A +120 + N/A N/A +122 + N/A N/A N/A +195  
Duke Blue Devils 340 Duke
-238 -140 + N/A -154 + N/A N/A -156 + N/A N/A N/A -245  

The Virginia Cavaliers will take on the Duke Blue Devils in this week's college football action. Kickoff is set for 3:30 p.m. EST at Brooks Field at Wallace Wade Stadium in Durham, N.C. The game will be broadcast live on ESPN2. Here's everything you need to know about Virginia vs. Duke odds, the latest college football spreads, college football over/unders and more.

This game is featured on my college football week 12 best bets piece!

The Duke Blue Devils opened as a -6.5 point favorite over Virginia. The total is set at over/under 58.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 11/10/25

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Duke vs. Virginia Best Bet

The Duke Blue Devils are the net success rate darlings. They are extremely efficient offensively, but their special teams have cost them games. This is a pseudo-playoff game, with the winner seemingly finding themselves in the ACC Championship game if all else goes right. With the status of Virginia quarterback Chandler Morris up in the air, this feels like the right time to get in on the Duke side before his status is announced. Duke has the 9th-ranked pass offense, and they are extremely efficient on early downs. I think Duke separates themselves as the top contender for the ACC in this matchup.

Duke vs. Virginia Best Bet: Duke Blue Devils -6.5 (-110)

(Pick from Dylan Wilkerson)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

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What Time is the Duke vs. Virginia Game?

The Blue Devils will take on the Cavaliers at 3:30 PM ET on Saturday, November 15th.

Where is the Duke vs. Virginia Game Being Played?

This game is going to be played at Wallace Wade Stadium in Durham, N.C

How Can I Watch The Duke vs. Virginia Game?

You can watch Duke vs. Virginia on ESPN2.

Can Duke Beat The Virginia Cavaliers?

Absolutely! Duke is a slight favorite in this game. Anything can happen in college football!

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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