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Featured Last Updated Oct 17 2025, 9:46 AM

Miami (FL) vs. Louisville: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Miami (FL) vs. Louisville: Prediction, Odds, Best Bet

Image Credit: Sam Navarro via Imagn Images

LOU @ MIA Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Louisville Cardinals 315 Louisville
+7.5 -110 +6 -110 + +6.5 -115 + +5.5 -105 + +6 -115 + +6.5 -125 + +6.5 -104 + +6.5 even + +6.5 -115 +6.5 -106 + +10.5 -112  
Miami (FL) Hurricanes 316 Miami (FL)
-7.5 -110 -6 -110 + -6.5 -105 + -5.5 -115 + -6 -105 + -6.5 -105 + -6.5 -118 + -6.5 -120 + -6.5 -105 -6.5 -118 + -10.5 -108  
Louisville Cardinals 315 Louisville
o53.5 -110 o24.5 -105 + N/A o24.5 +102 + o24.5 -105 + N/A o24.5 -102 + o24.5 -110 + o24.5 -105 o24.5 -108 + o49.5 -105  
Miami (FL) Hurricanes 316 Miami (FL)
u53.5 -110 u24.5 -115 + N/A u24.5 -122 + u24.5 -115 + N/A u24.5 -120 + u24.5 -110 + u24.5 -115 u24.5 -121 + u49.5 -115  
Louisville Cardinals 315 Louisville
+470 +245 + +230 + +235 + +235 + +210 + +245 + N/A N/A +230 + +340  
Miami (FL) Hurricanes 316 Miami (FL)
-650 -310 + -295 + -278 + -305 + -300 + -325 + N/A N/A -315 + -440  
Louisville Cardinals 315 Louisville
+7.5 -110 +3.5 -105 + +3.5 -120 + +3.5 -125 + +3.5 -125 + +3.5 -120 + +2.5 +104 + +4.5 -120 + +3.5 -120 +2.5 +102 + +10.5 -112  
Miami (FL) Hurricanes 316 Miami (FL)
-7.5 -110 -3.5 -115 + -3.5 -105 + -3.5 -105 + -3.5 -105 + -3.5 -110 + -2.5 -130 + -4.5 -110 + -3.5 -110 -2.5 -132 + -10.5 -108  
Louisville Cardinals 315 Louisville
o53.5 -110 o10.5 +110 + N/A o9.5 -140 + o10.5 +105 + o9.5 -150 + o10.5 +118 + o12.5 +110 + o10.5 +115 o11.5 +108 + o49.5 -105  
Miami (FL) Hurricanes 316 Miami (FL)
u53.5 -110 u10.5 -130 + N/A u9.5 +110 + u10.5 -135 + u9.5 +120 + u10.5 -148 + u12.5 -140 + u10.5 -155 u11.5 -137 + u49.5 -115  
Louisville Cardinals 315 Louisville
+470 +190 + +195 + +190 + +195 + +200 + +196 + N/A N/A +195 + +340  
Miami (FL) Hurricanes 316 Miami (FL)
-650 -230 + -250 + -250 + -240 + -280 + -265 + N/A N/A -286 + -440  
Louisville Cardinals 315 Louisville
+7.5 -110 N/A N/A +5.5 -102 + +5.5 -105 + N/A N/A N/A N/A N/A +10.5 -112  
Miami (FL) Hurricanes 316 Miami (FL)
-7.5 -110 N/A N/A -5.5 -118 + -5.5 -115 + N/A N/A N/A N/A N/A -10.5 -108  
Louisville Cardinals 315 Louisville
o53.5 -110 N/A N/A o23.5 -120 + o23.5 -110 + N/A N/A o22.5 -120 + N/A N/A o49.5 -105  
Miami (FL) Hurricanes 316 Miami (FL)
u53.5 -110 N/A N/A u23.5 even + u23.5 -110 + N/A N/A u22.5 -110 + N/A N/A u49.5 -115  
Louisville Cardinals 315 Louisville
+470 N/A N/A +240 + N/A N/A N/A N/A N/A N/A +340  
Miami (FL) Hurricanes 316 Miami (FL)
-650 N/A N/A -305 + N/A N/A N/A N/A N/A N/A -440  
Louisville Cardinals 315 Louisville
+7.5 -110 N/A N/A +2.5 -115 + N/A N/A +3.5 -114 + +3.5 -125 + N/A N/A +10.5 -112  
Miami (FL) Hurricanes 316 Miami (FL)
-7.5 -110 N/A N/A -2.5 -115 + N/A N/A -3.5 -114 + -3.5 -105 + N/A N/A -10.5 -108  
Louisville Cardinals 315 Louisville
o53.5 -110 o14 -110 + N/A o13.5 -130 + N/A N/A o14.5 +120 + o14.5 +110 + N/A N/A o49.5 -105  
Miami (FL) Hurricanes 316 Miami (FL)
u53.5 -110 u14 -110 + N/A u13.5 even + N/A N/A u14.5 -148 + u14.5 -140 + N/A N/A u49.5 -115  
Louisville Cardinals 315 Louisville
+470 +170 + N/A +145 + N/A N/A +186 + N/A N/A N/A +340  
Miami (FL) Hurricanes 316 Miami (FL)
-650 -205 + N/A -188 + N/A N/A -245 + N/A N/A N/A -440  
Louisville Cardinals 315 Louisville
+7.5 -110 N/A N/A +2.5 -105 + N/A N/A +2.5 -108 + +2.5 even + N/A N/A +10.5 -112  
Miami (FL) Hurricanes 316 Miami (FL)
-7.5 -110 N/A N/A -2.5 -125 + N/A N/A -2.5 -122 + -2.5 -130 + N/A N/A -10.5 -108  
Louisville Cardinals 315 Louisville
o53.5 -110 o10 -110 + N/A o10.5 +110 + N/A N/A o10.5 +102 + o9.5 -130 + N/A N/A o49.5 -105  
Miami (FL) Hurricanes 316 Miami (FL)
u53.5 -110 u10 -110 + N/A u10.5 -140 + N/A N/A u10.5 -128 + u9.5 even + N/A N/A u49.5 -115  
Louisville Cardinals 315 Louisville
+470 +185 + N/A +185 + N/A N/A +176 + N/A N/A N/A +340  
Miami (FL) Hurricanes 316 Miami (FL)
-650 -220 + N/A -245 + N/A N/A -235 + N/A N/A N/A -440  
Louisville Cardinals 315 Louisville
+7.5 -110 +0.5 -115 + N/A +2.5 -105 + N/A N/A +2.5 -108 + +0.5 -115 + N/A N/A +10.5 -112  
Miami (FL) Hurricanes 316 Miami (FL)
-7.5 -110 -0.5 -105 + N/A -2.5 -125 + N/A N/A -2.5 -122 + -0.5 -115 + N/A N/A -10.5 -108  
Louisville Cardinals 315 Louisville
o53.5 -110 o12.5 -110 + N/A o13.5 -115 + N/A N/A o12.5 -114 + o13.5 -105 + N/A N/A o49.5 -105  
Miami (FL) Hurricanes 316 Miami (FL)
u53.5 -110 u12.5 -110 + N/A u13.5 -115 + N/A N/A u12.5 -110 + u13.5 -125 + N/A N/A u49.5 -115  
Louisville Cardinals 315 Louisville
+470 +150 + N/A +175 + N/A N/A +176 + N/A N/A N/A +340  
Miami (FL) Hurricanes 316 Miami (FL)
-650 -180 + N/A -230 + N/A N/A -225 + N/A N/A N/A -440  

The Louisville Cardinals will take on the Miami (FL) Hurricanes in this week's NCAAF action. Kickoff is set for 7:00 p.m. EDT at Hard Rock Stadium in Miami Gardens, Fla. The game will be broadcast live on ESPN. Here's everything you need to know about Louisville vs. Miami (FL) odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Miami (FL) Hurricanes opened as a -13.5 point favorite over Louisville. The total is set at over/under 51.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/17/25

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Louisville vs. Miami (FL) Best Bet

Miami may ultimately win the game, but the statistical gap between these teams does not justify a full two-touchdown spread.

Louisville’s pass defense is elite, and its balanced offensive approach should keep the game within striking distance.

Miami’s offense is talented but not dominant, and the Hurricanes’ lack of discipline and occasional inconsistency on early downs make them vulnerable to a physical, assignment-sound opponent like Louisville.

Expect the Cardinals to frustrate Miami’s rhythm, control possession, and win the battle of field position often enough to remain competitive deep into the fourth quarter.

This matchup has all the makings of a 27-20 or 28-17 type of result.

Louisville vs. Miami (FL) Best Bet: Louisville +14 or Better

(Pick from John Feltman)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Louisville vs. Miami (FL) Game?

The Louisville Cardinals will take on the Miami (FL) Hurricanes at 7:00 ET on Friday, October 17th.

Where is the Louisville Cardinals vs. Miami Hurricanes Game Being Played?

This game is going to be played at Hard Rock Stadium in Miami, FL.

How Can I Watch Louisville vs. Miami (FL)?

You can watch Louisville vs. Miami (FL) on ESPN.

Can Louisville Beat Miami (FL)?

It will take Louisville's best effort of the year to overcome the Hurricanes. But coming off the bye, you can expect Louisville to bring their "A" game.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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