USC vs. Notre Dame: Prediction, Odds, Best Bet

Dylan Wilkerson Sports Betting Expert

8 minute read

_{Image Credit: MICHAEL CLUBB/SOUTH BEND TRIBUNE / USA TODAY NETWORK via Imagn Images}

USC @ Notre Dame Betting Odds

• Spread
• Total
• Moneyline

Time	Open	Bet365	BetMGM	DraftKings	Caesars	ESPNBet	FanDuel	HardRock	Fanatics	RiversCasino	Consensus
	Open	›	›	›	›	›	›	›	›	›
415 USC	+13.5 -110	+9 -110	+9.5 -115	+9.5 -108	+9 -110	+9.5 -110	+9.5 -110	+9.5 -105	+8.5 -105	+9.5 -110	+9.5 -108
416 Notre Dame	-13.5 -110	-9 -110	-9.5 -105	-9.5 -112	-9 -110	-9.5 -110	-9.5 -110	-9.5 -115	-8.5 -115	-9.5 -113	-9.5 -112
Matchup
	Open	›	›	›	›	›	›	›	›	›
415 USC	o53.5 -110	o61.5 -110	o61.5 -110	o61.5 -110	o61.5 -110	o61.5 even	o61.5 -110	o61.5 -110	o61 -110	o61.5 -109	o61.5 -110
416 Notre Dame	u53.5 -110	u61.5 -110	u61.5 -110	u61.5 -110	u61.5 -110	u61.5 -120	u61.5 -110	u61.5 -110	u61 -110	u61.5 -114	u61.5 -110
Matchup
	Open	›	›	›	›	›	›	›	›	›
415 USC	+285	+265	+275	+260	+260	+270	+265	+260	+265	+260	+260
416 Notre Dame	-360	-330	-350	-325	-335	-340	-345	-350	-340	-335	-325
Matchup

The USC Trojans will take on the Notre Dame Fighting Irish in this week's college football action. Kickoff is set for 7:30 p.m. EDT at Notre Dame Stadium in South Bend, Ind. The game will be broadcast live on NBC. Here's everything you need to know about USC vs. Notre Dame odds, the latest college football spreads, college football over/unders and more.

The Notre Dame Fighting Irish opened as a -9.5 point favorite over USC. The total is set at over/under 61.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/15/25

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USC vs. Notre Dame Best Bet

USC has one of the best offenses in college football. They are currently rated #1 in EPA/pass and #4 in EPA/rush. They are top 5 in both early-downs EPA/play and late-down success rate. This offense will be going against a Notre Dame defense that is half as strong as they were last season.

USC also has the #1 rated safety in the country according to PFF, Bishop Fitzgerald. USC's offensive line did not allow a sack against Michigan last week (one of the strongest pass-rush units in the country). I think USC wins this game and knocks Notre Dame out of playoff contention.

USC vs. Notre Dame Best Bet: USC Trojans +9.5 (-105)

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(Pick from Dylan Wilkerson)

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What Time is the USC vs. Notre Dame Game?

The Trojans will take on the Fighting Irish at 7:30 PM ET on Saturday, October 18th.

Where is the USC vs. Notre Dame Game Being Played?

This game is going to be played at Notre Dame Stadium in South Bend, Ind.

How Can I Watch The USC vs. Notre Dame Game?

You can watch USC vs. Notre Dame on NBC.

Can USC Beat The Notre Dame Fighting Irish?

Absolutely! USC is an underdog in this game, but anything is possible in college football!

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson