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Last Updated Sep 16, 2022, 7:10 PM

Florida State Seminoles vs. Louisville Cardinals Picks, Predictions, Odds

The Florida State Seminoles and Louisville Cardinals play a conference game Friday at Cardinal Stadium in Louisville, Kentucky. Kickoff is scheduled for 7:30 p.m. ET, and the game can be viewed on ESPN.

FLORIDA STATE SEMINOLES vs. LOUISVILLE CARDINALS BETTING PREDICTION

The Seminoles opened the series with a 47-7 victory over Duquesne of the FCS in Week 0 back on Aug. 27. That's all well and good, but the real question about whether FSU's Mike Norvell had this team turning a corner would be if the Seminoles could handle themselves against LSU, in New Orleans. The Seminoles posted the 24-23 victory as 4-point underdogs, winning by way of a blocked extra point in the closing seconds. It was a miraculous win, and the kind of victory which can change the trajectory of a program.

Florida State has been off since Sept. 4, so it enters this game rested, too. The Seminoles won and covered as the underdog against LSU, the only FBS foe it has faced so far. The UNDER has cashed in each of its games.

Louisville already has a conference under its belt, and it didn't end well. The Cardinals were destroyed by Dino Babers' Orange team in Syracuse, falling 31-7, losing outright as a 5.5-point favorite. The Cardinals were on the flip side as a 5.5-point underdog at UCF last Friday night, but Louisville turned the tables and picked up a 20-14 win. The UNDER has cashed in each of its games, like FSU.

Score Prediction: Florida State 27, Louisville 24
Best Bet: UNDER 57.5 (-110)

FLORIDA STATE SEMINOLES vs. LOUISVILLE CARDINALS BETTING ODDS

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FLORIDA STATE SEMINOLES vs. LOUISVILLE CARDINALS BETTING RESOURCES

Date: Friday, Sept. 16, 2022
Matchup: ACC
Venue: Cardinal Stadium
Location: Louisville, Kentucky
Time-TV: ESPN, 7:30 p.m. ET

FLORIDA STATE SEMINOLES BETTING ANALYSIS

The Seminoles have not piled up giant offensive numbers so far this season, but they're getting the job done. QB Jordan Travis has completed 66.0% of his passes for 467 yards, 2 TD and 0 INT, while running for 42 yards and another score. RB Treshaun Ward has racked up some strong numbers, going for a team-high 176 yards and 2 TD. Florida State has rolled up seven rushing touchdowns, with six different players finding the end zone.

The defense has allowed just 256.0 total yards per game to check in 18th in the nation in the early rankings, including just 140.0 passing yards per outing to rank 16th. DL Jared Verse has registered three sacks to lead the way.

Florida State enters the game 4-1 ATS in the past five games dating back to last season, and the Seminoles have managed a 4-1 ATS mark in the past five road outings, while going 5-1 ATS in the past six appearances on a Friday.

For FSU, it's all about the UNDER, cashing both games this season, and in six straight outings dating back to last season. The UNDER is also 6-1 in the past seven on the road, and 4-1 in the previous five ACC games, while going 5-2 in the past seven appearances on a Friday.

Florida State has covered five of its past six Friday appearances. (Getty Images)

LOUISVILLE CARDINALS BETTING ANALYSIS

QB Malik Cunningham came alive in the UCF game, ripping off a 43-yard scoring run to give the Cards the lead late in the third quarter. They never looked back, winning 20-14. Louisville registered 226 yards on the ground against the Knights, and they protected the ball better after going minus-3 in turnovers at Syracuse.

Louisville has struggled against winning teams, going 12-28-1 ATS in the past 41 games against winning teams. The UNDER is 6-1 in the past seven games in the month of September, while going 5-2 in the past seven ACC battles, including the Syracuse game. The OVER is 11-5 in the past 16 home games, however, and the OVER is 4-0 in the past four meetings in Louisville, while going 6-2 in the previous eight head-to-head battles.

FSU leads the all-time series 16-6, but Louisville has won the past two in the series, including last Sept. 25 at Tallahassee by a 31-23 count. The last time these teams met in Louisville, the Cards routed the Noles 48-16, and Louisville has won four of the previous six in the series. However, this season, the Cardinals have been far less consistent than the Seminoles, and Louisville is still looking for its first TD pass of the season.

FLORIDA STATE SEMINOLES vs. LOUISVILLE CARDINALS BETTING TRENDS

  • FSU is 4-1 ATS in the past five games overall.
  • FSU is 4-1 ATS in the past five road games.
  • FSU is 5-1 ATS in the past six Friday games.
  • Louisville is 12-28-1 ATS in the past 41 vs. winning teams.
  • UNDER is 6-0 in the past six games overall for FSU.
  • UNDER is 6-1 in the past seven road games for FSU.
  • UNDER is 4-1 in the past five ACC games for FSU.
  • UNDER is 5-2 in the past seven Friday games for FSU.
  • OVER is 11-5 in the past 16 home games for Louisville.
  • UNDER is 5-2 in the past seven ACC games for Louisville.
  • UNDER is 6-1 in the past seven September games for Louisville.
  • FSU is 1-5 ATS in the past six meetings.
  • OVER is 6-2 in the past eight meetings.
  • OVER is 4-0 in the past four meetings in Louisville.
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