College Football Week 3 Best Bets, College Football Picks

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After a week of subpar matchups, week 3 of college football brings us plenty of top-25 matchups! Here are our experts best bets for this weeks' college football slate.
Check out the latest college football odds, and the latest college football week 3 odds report.
Updated on 9/12/25

Notre Dame Fighting Irish vs. Texas A&M Aggies Best Bet
Marcel Reed has been impressive this season, throwing for 7 touchdowns and over 500 yards in the first two games of their season. He has been great with his arm, and his feet as well.
Reed's ability to get it done on the ground coupled with A&M's offensive line and their running back room make A&M's offensive attack unpredictable. Notre Dame's offensive line will get exposed against Texas A&M's defensive front, and the Aggies will keep this game close.
Texas A&M Aggies vs. Notre Dame Fighting Irish Best Bet: Texas A&M +6.5 (-105)
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(Pick from Dylan Wilkerson)
Georgia Bulldogs vs. Tennessee Volunteers Best Bet
Through two games, the Georgia offense looks fine, but that’s not that’s going to cut it once this schedule ramps up. The Bulldogs draw four ranked opponents in their next five games, and it still appears that they’re not 100% confident in who they want to be offensively.
Stockton’s meager average depth of target of 5.1 yards (62nd) is troubling because they won’t be able to dink and dunk their way downfield in SEC play. No Power Four quarterback with two starts under their belt in 2025 has a lower aDOT.
He has yet to make a Big-Time Throw, according to PFF, and much of that can be laid at Bobo’s feet. The running game grades out well, but I don’t put any stock in what they’ve accomplished against the defensive fronts of Marshall and Austin Peay.
I have enough concerns about Stockton, Georgia's offensive line in pass protection and Bobo that I’ll be playing Tennessee +3.5 on Saturday.
Georgia vs. Tennessee Best Bet: Tennessee +3.5 (-110)
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(Pick from Mike Calabrese)
Florida Gators vs. LSU Tigers Best Bet
What a perfect time to buy back in on the Florida Gators. After a devasting (and possible career ending) loss to the South Florida Bulls, Florida has something to prove in this matchup. Although the scoreboard tells a different story, Florida had a higher net success rate than USF, indicating that procedurally, Florida was stronger.
Florida notable took down Brian Kelly's unit last season. While everyone else is zigging, we are going to zag and back the Florida Gators this weekend.
Florida Gators vs. LSU Tigers Best Bet: Forida +7.5 (-110)
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(Pick from Dylan Wilkerson)
Clemson Tigers vs. Georgia Tech Best Bet
Georgia Tech's offense has been great, averaging over 570 total yards and 43 points per game through the first two weeks of the season. Haynes King dynamic playmaking has been the catalyst for the Yellow Jackets' success. If Haynes King is completely healthy, the Jackets' offense could be a huge problem for Clemson.
Clemson has gotten off to a slow start, and their defense has yet to look as strong as we expected ahead of the season. I expect Georgia Tech to keep this one close.
Clemson Tigers vs. Georgia Tech Best Bet: Georgia Tech +3 (-105)
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(Pick from Dylan Wilkerson)
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