Cardinals vs. Rams Predictions: Cardinals Keep NFC West Game Close
Dylan Wilkerson Sports Betting Expert
Updated on 10/15/26
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The Arizona Cardinals will take on the Los Angeles Rams in this week's NFL action. Kickoff is set for 4:05 PM EST at SoFi Stadium in Inglewood, CA. The game will be broadcast live on FOX. Here's everything you need to know about Cardinals vs. Rams odds, the latest NFL spreads, NFL over/unders and more.
ARI @ LA Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open |  › |  › |  › |  › |  › |  › |  › |  › |  | ||
 277 Cardinals | +13.5 -110 | +12.5 -110 | +12.5 -110 | +12.5 -108 | +12.5 -107 | +12.5 -112 | +12.5 -110 | +12.5 -110 | +12.5 -108 | +12.5 -108 | |
 278 Rams | -13.5 -110 | -12.5 -110 | -12.5 -108 | -12.5 -112 | -12.5 -113 | -12.5 -108 | -12.5 -110 | -12.5 -110 | -12.5 -113 | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o51.5 -112 | o52 -108 | o51.5 -112 | o51.5 -114 | o51.5 -115 | o51.5 -110 | o52 -110 | o52 -109 | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u51.5 -108 | u52 -110 | u51.5 -108 | u51.5 -106 | u51.5 -105 | u51.5 -110 | u52 -110 | u52 -110 | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +600 | +575 | +600 | +600 | +540 | +575 | +575 | +510 | +600 | |
| 278 Rams | -700 | -900 | -750 | -900 | -950 | -770 | -850 | -850 | -770 | -900 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +13.5 -110 | +3.5 -125 | +3.5 -130 | +3.5 -120 | N/A | +3.5 -134 | +3.5 -125 | +3.5 -120 | +3.5 -120 | +12.5 -108 | |
| 278 Rams | -13.5 -110 | -3.5 +105 | -3.5 even | -3.5 even | N/A | -3.5 +110 | -3.5 -105 | -3.5 even | -3.5 -105 | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o9.5 -150 | o10.5 +125 | o10.5 +130 | N/A | o9.5 -152 | o9.5 -155 | o9.5 -165 | o11.5 +123 | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u9.5 +125 | u10.5 -160 | u10.5 -155 | N/A | u9.5 +126 | u9.5 +120 | u9.5 +120 | u11.5 -155 | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +210 | +210 | +200 | N/A | +210 | N/A | +210 | +225 | +600 | |
| 278 Rams | -700 | -260 | -275 | -245 | N/A | -265 | N/A | -285 | -295 | -900 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +13.5 -110 | +6.5 +105 | +6.5 +110 | +6.5 +105 | +6.5 +104 | +7.5 -125 | +6.5 even | +7.5 -135 | +6.5 +102 | +12.5 -108 | |
| 278 Rams | -13.5 -110 | -6.5 -125 | -6.5 -130 | -6.5 -125 | -6.5 -125 | -7.5 +105 | -6.5 -130 | -7.5 +110 | -6.5 -127 | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o26.5 -110 | o26.5 -110 | o26.5 -110 | o26.5 -109 | o26.5 -110 | o26.5 -110 | o26.5 -115 | o26.5 -120 | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u26.5 -110 | u26.5 -108 | u26.5 -110 | u26.5 -110 | u26.5 -110 | u26.5 -120 | u26.5 -115 | u26.5 -104 | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +300 | +300 | +310 | +295 | +330 | N/A | +290 | +300 | +600 | |
| 278 Rams | -700 | -380 | -375 | -395 | -390 | -440 | N/A | -375 | -385 | -900 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +13.5 -110 | N/A | N/A | +3.5 -130 | N/A | +3.5 -128 | +3.5 -130 | N/A | N/A | +12.5 -108 | |
| 278 Rams | -13.5 -110 | N/A | N/A | -3.5 even | N/A | -3.5 +104 | -3.5 even | N/A | N/A | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o10.5 +110 | N/A | o10.5 +110 | N/A | o10.5 +102 | o10.5 even | N/A | N/A | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u10.5 -140 | N/A | u10.5 -140 | N/A | u10.5 -126 | u10.5 -130 | N/A | N/A | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +195 | N/A | +195 | N/A | +210 | N/A | N/A | N/A | +600 | |
| 278 Rams | -700 | -260 | N/A | -260 | N/A | -265 | N/A | N/A | N/A | -900 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +13.5 -110 | N/A | N/A | +3.5 -110 | N/A | +4.5 -128 | +3.5 even | N/A | N/A | +12.5 -108 | |
| 278 Rams | -13.5 -110 | N/A | N/A | -3.5 -120 | N/A | -4.5 +104 | -3.5 -130 | N/A | N/A | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o16.5 even | N/A | o16.5 even | N/A | o16.5 -102 | o16.5 -105 | N/A | N/A | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u16.5 -130 | N/A | u16.5 -130 | N/A | u16.5 -120 | u16.5 -125 | N/A | N/A | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +220 | N/A | +200 | N/A | +250 | N/A | N/A | N/A | +600 | |
| 278 Rams | -700 | -290 | N/A | -270 | N/A | -325 | N/A | N/A | N/A | -900 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +13.5 -110 | +6.5 -115 | N/A | +6.5 -120 | N/A | +5.5 -105 | +6.5 -120 | N/A | +6.5 -114 | +12.5 -108 | |
| 278 Rams | -13.5 -110 | -6.5 -105 | N/A | -6.5 -110 | N/A | -5.5 -115 | -6.5 -110 | N/A | -6.5 -108 | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o25.5 -110 | N/A | o25.5 -105 | N/A | o25.5 -110 | o25.5 -115 | N/A | o25.5 -108 | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u25.5 -110 | N/A | u25.5 -115 | N/A | u25.5 -110 | u25.5 -120 | N/A | u25.5 -114 | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +265 | N/A | +250 | N/A | +260 | N/A | N/A | +280 | +600 | |
| 278 Rams | -700 | -330 | N/A | -345 | N/A | -320 | N/A | N/A | -375 | -900 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +13.5 -110 | +2.5 -110 | N/A | +2.5 +105 | N/A | +2.5 -102 | +2.5 -105 | N/A | N/A | +12.5 -108 | |
| 278 Rams | -13.5 -110 | -2.5 -120 | N/A | -2.5 -135 | N/A | -2.5 -120 | -2.5 -125 | N/A | N/A | -12.5 -112 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | o47.5 -110 | o13.5 -130 | N/A | o14.5 even | N/A | o13.5 -128 | o13.5 -135 | N/A | N/A | o51.5 -112 | |
| 278 Rams | u47.5 -110 | u13.5 even | N/A | u14.5 -130 | N/A | u13.5 +106 | u13.5 +105 | N/A | N/A | u51.5 -108 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 277 Cardinals | +500 | +170 | N/A | +175 | N/A | +176 | N/A | N/A | N/A | +600 | |
| 278 Rams | -700 | -220 | N/A | -230 | N/A | -220 | N/A | N/A | N/A | -900 | |
The Los Angeles Rams opened as a -12.5 point favorite to Arizona. The total is set at over/under 51.5 total points scored by both teams combined.
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Cardinals vs. Rams Prediction
The Cardinals have a slight rest advantage here given that the Rams played on Monday Night Football (in an overtime affair, no less).
This game is your classic "these guys get paid too" showdown. While there may be a big talent gap between these teams, this Cardinals team is nothing to sneeze at. They rank 10th in offensive success rate, and Jacoby Brissett boasts a higher completion percentage over expected than Matthew Stafford.
The Cardinals could pull off a divisional upset against the Rams.
Cardinals vs Rams Prediction: Arizona Cardinals +12.5 (-110)
(Pick from Dylan Wilkerson)
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