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Lions vs. Panthers Predictions: Sunday Night Football Brings Points

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Lions vs. Panthers Predictions: Sunday Night Football Brings Points

The Detroit Lions will take on the Carolina Panthers in this week's NFL action. Kickoff is set for 8:20 PM EST at Bank of America Stadium in Charlotte, NC. The game will be broadcast live on NBC. Here's everything you need to know about Lions vs. Panthers odds, the latest college football spreads, college football over/unders and more.

DET @ CAR Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Detroit Lions 277 Lions
-3 -110 -2.5 -125 -2.5 -120 -3.5 +102 -2.5 -127 -3.5 -100 -2.5 -125 -2.5 -125 -2.5 -122 -4.5 -105  
Carolina Panthers 278 Panthers
+3 -110 +2.5 +105 +2.5 even +3.5 -122 +2.5 +105 +3.5 -120 +2.5 -105 +2.5 +105 +2.5 -104 +4.5 -115  
Final
Detroit Lions 277 Lions
o47.5 -110 o25.5 -115 o26.5 -112 o26.5 -108 o26.5 -104 o26.5 -120 o25.5 -120 o26.5 -115 o24.5 -109 o52.5 -105  
Carolina Panthers 278 Panthers
u47.5 -110 u25.5 -105 u26.5 -105 u26.5 -112 u26.5 -117 u26.5 -100 u25.5 -110 u26.5 -115 u24.5 -113 u52.5 -115  
Final
Detroit Lions 277 Lions
-155 -185 -175 -175 -179 -182 N/A -180 -167 -225  
Carolina Panthers 278 Panthers
+130 +155 +140 +145 +147 +148 N/A +150 +133 +185  
Final
Detroit Lions 277 Lions
-3 -110 -0.5 -110 -0.5 even -0.5 +102 N/A -1.5 +112 -0.5 even -0.5 +105 -1.5 +112 -4.5 -105  
Carolina Panthers 278 Panthers
+3 -110 +0.5 -110 +0.5 -130 +0.5 -122 N/A +1.5 -138 +0.5 -130 +0.5 -125 +1.5 -139 +4.5 -115  
Final
Detroit Lions 277 Lions
o47.5 -110 o9.5 -130 o9.5 -165 o9.5 -148 N/A o9.5 -154 o9.5 -145 o9.5 -155 o9.5 -157 o52.5 -105  
Carolina Panthers 278 Panthers
u47.5 -110 u9.5 +110 u9.5 +130 u9.5 +124 N/A u9.5 +126 u9.5 +110 u9.5 +115 u9.5 +125 u52.5 -115  
Final
Detroit Lions 277 Lions
-155 -180 -165 -155 N/A -158 N/A -180 -139 -225  
Carolina Panthers 278 Panthers
+130 +150 +130 +130 N/A +128 N/A +135 +116 +185  
Final
Detroit Lions 277 Lions
-3 -110 -1.5 -120 N/A -2.5 -115 N/A -2.5 -110 -1.5 -120 -2.5 -110 -2.5 -108 -4.5 -105  
Carolina Panthers 278 Panthers
+3 -110 +1.5 even N/A +2.5 -115 N/A +2.5 -110 +1.5 -110 +2.5 -110 +2.5 -115 +4.5 -115  
Final
Detroit Lions 277 Lions
o47.5 -110 o25.5 -110 N/A o25.5 -118 N/A o25.5 -120 o25.5 -115 o24.5 -120 o26.5 -109 o52.5 -105  
Carolina Panthers 278 Panthers
u47.5 -110 u25.5 -110 N/A u25.5 -102 N/A u25.5 -100 u25.5 -115 u24.5 -110 u26.5 -114 u52.5 -115  
Final
Detroit Lions 277 Lions
-155 -150 N/A -166 N/A -166 N/A -165 -159 -225  
Carolina Panthers 278 Panthers
+130 +125 N/A +130 N/A +142 N/A +135 +128 +185  
Final
Detroit Lions 277 Lions
-3 -110 N/A N/A -1.5 -115 N/A -1.5 -110 -1.5 -115 -0.5 -115 N/A -4.5 -105  
Carolina Panthers 278 Panthers
+3 -110 N/A N/A +1.5 -115 N/A +1.5 -110 +1.5 -115 +0.5 -105 N/A +4.5 -115  
Final
Detroit Lions 277 Lions
o47.5 -110 o15.5 -115 N/A o16.5 even N/A o16.5 -106 o15.5 -120 o13.5 -195 N/A o52.5 -105  
Carolina Panthers 278 Panthers
u47.5 -110 u15.5 -115 N/A u16.5 -130 N/A u16.5 -116 u15.5 -110 u13.5 +140 N/A u52.5 -115  
Final
Detroit Lions 277 Lions
-155 -160 N/A -160 N/A -168 N/A -165 N/A -225  
Carolina Panthers 278 Panthers
+130 +125 N/A +124 N/A +136 N/A +125 N/A +185  
Final
Detroit Lions 277 Lions
-3 -110 N/A N/A -0.5 -105 N/A -1.5 +114 -0.5 even -0.5 even N/A -4.5 -105  
Carolina Panthers 278 Panthers
+3 -110 N/A N/A +0.5 -125 N/A +1.5 -138 +0.5 -135 +0.5 -120 N/A +4.5 -115  
Final
Detroit Lions 277 Lions
o47.5 -110 o10.5 +110 N/A o10.5 +105 N/A o10.5 +112 o10.5 +115 o9.5 -170 N/A o52.5 -105  
Carolina Panthers 278 Panthers
u47.5 -110 u10.5 -140 N/A u10.5 -135 N/A u10.5 -136 u10.5 -145 u9.5 +125 N/A u52.5 -115  
Final
Detroit Lions 277 Lions
-155 -145 N/A -154 N/A -158 N/A -160 N/A -225  
Carolina Panthers 278 Panthers
+130 +115 N/A +120 N/A +128 N/A +120 N/A +185  
Final
Detroit Lions 277 Lions
-3 -110 -0.5 even N/A -0.5 -120 N/A -1.5 +112 -0.5 -110 -0.5 -105 N/A -4.5 -105  
Carolina Panthers 278 Panthers
+3 -110 +0.5 -130 N/A +0.5 -110 N/A +1.5 -136 +0.5 -120 +0.5 -115 N/A +4.5 -115  
Final
Detroit Lions 277 Lions
o47.5 -110 o14.5 -105 N/A o14.5 -110 N/A o14.5 -102 o14.5 even o13.5 -135 N/A o52.5 -105  
Carolina Panthers 278 Panthers
u47.5 -110 u14.5 -125 N/A u14.5 -120 N/A u14.5 -118 u14.5 -130 u13.5 even N/A u52.5 -115  
Final
Detroit Lions 277 Lions
-155 -145 N/A -154 N/A -142 N/A -150 N/A -225  
Carolina Panthers 278 Panthers
+130 +115 N/A +120 N/A +118 N/A +115 N/A +185  

The Detroit Lions opened as a -3.5 point favorite to Carolina. The total is set at over/under 50.5 total points scored by both teams combined.

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Updated on 10/15/26

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Lions vs. Panthers Prediction

Detroit's offense needs no introduction. They've scored exactly 31 points in all 3 games to begin the season. Detroit will face a Carolina defense likely missing both starting corners.

Carolina's offense has been a pleasant surprise. The new coaching staff has revamped the passing game. Bryce Young leads the league in yards through 3 games. Carolina ranks 2nd in neutral pass rate and 2nd in pace. Detroit's scuffling defense ranks 31st in EPA/play.

Updated on 10/15/26

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Lions vs. Panthers Prediction: Detroit Lions @ Carolina Panthers o50.5 (-115)

(Pick from Charlie Wright)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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