Bills vs 49ers Odds
BUF @ SF Odds
| Time | Open | DraftKings | FanDuel | Consensus | |
|---|---|---|---|---|---|
| Final |  |  › |  › |  | |
 485 Bills | -2.5 -110 | +1 -120 | +1.5 -104 | +1.5 -109 | |
 486 49ers | +2.5 -110 | -1 -103 | -1.5 -118 | -1.5 -109 | |
| Final | | › | › | | |
| 485 Bills | o48 -110 | o47 -110 | o47.5 -115 | o48 -109 | |
| 486 49ers | u48 -110 | u47 -110 | u47.5 -105 | u48 -109 | |
| Final | | › | › | | |
| 485 Bills | -134 | -107 | +108 | +105 | |
| 486 49ers | +114 | -107 | -126 | -124 | |
| Time | Open | DraftKings | FanDuel | Consensus | |
|---|---|---|---|---|---|
| Final | | › | › | | |
| 485 Bills | -2.5 -110 | +0.5 -117 | +0.5 -110 | +1.5 -109 | |
| 486 49ers | +2.5 -110 | -0.5 -105 | -0.5 -110 | -1.5 -109 | |
| Final | | › | › | | |
| 485 Bills | o48 -110 | o23.5 -136 | o24 +105 | o48 -109 | |
| 486 49ers | u48 -110 | u23.5 +102 | u24 -125 | u48 -109 | |
| Final | | › | › | | |
| 485 Bills | -134 | +102 | +106 | +105 | |
| 486 49ers | +114 | -122 | -128 | -124 | |
| Time | Open | DraftKings | FanDuel | Consensus | |
|---|---|---|---|---|---|
| Final | | › | › | | |
| 485 Bills | -2.5 -110 | -4.5 -110 | +0.5 -110 | +1.5 -109 | |
| 486 49ers | +2.5 -110 | +4.5 -121 | -0.5 -110 | -1.5 -109 | |
| Final | | › | › | | |
| 485 Bills | o48 -110 | o34.5 +114 | o23.5 -110 | o48 -109 | |
| 486 49ers | u48 -110 | u34.5 -152 | u23.5 -110 | u48 -109 | |
| Final | | › | › | | |
| 485 Bills | -134 | N/A | +105 | +105 | |
| 486 49ers | +114 | N/A | -120 | -124 | |
| Time | Open | DraftKings | FanDuel | Consensus | |
|---|---|---|---|---|---|
| Final | | › | › | | |
| 485 Bills | -2.5 -110 | +0.5 -159 | +0.5 -146 | +1.5 -109 | |
| 486 49ers | +2.5 -110 | -0.5 +132 | -0.5 +120 | -1.5 -109 | |
| Final | | › | › | | |
| 485 Bills | o48 -110 | o9.5 -136 | o10 +112 | o48 -109 | |
| 486 49ers | u48 -110 | u9.5 +102 | u10 -138 | u48 -109 | |
| Final | | › | › | | |
| 485 Bills | -134 | +108 | +110 | +105 | |
| 486 49ers | +114 | -127 | -128 | -124 | |
| Time | Open | DraftKings | FanDuel | Consensus | |
|---|---|---|---|---|---|
| Final | | › | › | | |
| 485 Bills | -2.5 -110 | N/A | PK even | +1.5 -109 | |
| 486 49ers | +2.5 -110 | N/A | PK -122 | -1.5 -109 | |
| Final | | › | › | | |
| 485 Bills | o48 -110 | N/A | N/A | o48 -109 | |
| 486 49ers | u48 -110 | N/A | N/A | u48 -109 | |
| Final | | › | › | | |
| 485 Bills | -134 | N/A | even | +105 | |
| 486 49ers | +114 | N/A | -122 | -124 | |
Bills @ 49ers Betting Trends
| Final | Spread | Total | Moneyline | |||
|---|---|---|---|---|---|---|
| 485 Bills | 7-5 ATS | 9-3 O/U | 9-3 SU | Create Free Account | ||
| 486 49ers | 5-7 ATS | 6-6 O/U | 5-7 SU | |||
| Open | BUF -2.5 | o48 | -134 | |||
| Consensus | SF -1.5 | o48 | -124 | |||
| Final | Spread | Total | Moneyline | |||
| 485 Bills | 7-5 ATS | 9-3 O/U | 9-3 SU | Create Free Account | ||
| 486 49ers | 5-7 ATS | 6-6 O/U | 5-7 SU | |||
| Open | BUF -2.5 | o48 | -134 | |||
| Consensus | SF -1.5 | o48 | -124 | |||
Bills injuries
| Pos | Player | Status |
|---|---|---|
| OT | Tommy Doyle (Undisclosed) | Out |
49ers injuries
| Pos | Player | Status |
|---|---|---|
| OT | Trent Williams (Personal) | Out |
| LB | Dre Greenlaw (Achilles) | Out |
| S | Talanoa Hufanga (Knee) | Out |
| DL | Drake Jackson (Knee) | Out |
| WR | Ricky Pearsall (Undisclosed) | Out |
BUF @ SF Line Movements
Bills vs. 49ers Head-to-Head
| Date | Team | Opp | Close | Result | ATS/OU |
|---|---|---|---|---|---|
| Dec 7, 2020 | 49ers | Bills | -1.5 / 48 | Lost 24-34 | Lost / Over |
| Oct 16, 2016 | 49ers | @Bills | +7.5 / 44.5 | Lost 16-45 | Lost / Over |
| Oct 7, 2012 | 49ers | Bills | +10 / 45.5 | Won 45-3 | Won / Over |
| Nov 30, 2008 | 49ers | @Bills | -6.5 / 43 | Won 10-3 | Won / Under |
| Dec 26, 2004 | 49ers | Bills | +11.5 / 44 | Lost 7-41 | Lost / Over |
| Dec 2, 2001 | 49ers | Bills | +8 / 42 | Won 35-0 | Won / Under |
| Oct 4, 1998 | 49ers | @Bills | -10 / 44 | Lost 21-26 | Lost / Over |
| Dec 3, 1995 | 49ers | Bills | +14 / 46 | Won 27-17 | Won / Under |
| Sep 13, 1992 | 49ers | Bills | +3.5 / 44.5 | Lost 31-34 | Won / Over |
| Dec 17, 1989 | 49ers | Bills | +5 / 43.5 | Won 21-10 | Won / Under |
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