NFL Wild Card Round: Buffalo Bills vs. Jacksonville Jaguars Prediction, Odds, Preview

Dylan Wilkerson Sports Betting Expert

8 minute read

_{Featured Image Credit: Corey Perrine/Florida Times-Union / USA TODAY NETWORK via Imagn Images}

The Bills will take on the Jaguars in this week's NFL action. Kickoff is set for 1:00 p.m. EST at EverBank Stadium in Jacksonville, Fla. The game will be broadcast live on CBS. Here's everything you need to know about Bills vs. Jaguars odds, the latest NFL spreads, NFL over/unders and more.

The Bills opened as a -1.5 point favorite over Jaguars. The total is set at over/under 51.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 2/20/26

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Buffalo Bills vs. Jacksonville Jaguars Prediction

The Buffalo Bills have one of the worst rush defenses in the NFL, ranking 31st in rush EPA allowed. Travis Etienne is poised to take advantage of this mismatch, setting up Trevor Lawrence and the passing game.

The Bills offense has been strong this season, but their strength of schedule comes in at 29th indicating that this success could be a product of their schedule. Jacksonville ranks 5th in EPA allowed on defense, with a particular strength against the pass.

The AFC South Champions take this one and move onto the Divisional Round.

Buffalo Bills vs. Jacksonville Jaguars Prediction: Jacksonville Jaguars moneyline (+100)

(Pick from Dylan Wilkerson)

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What Time is the Buffalo Bills vs. Jacksonville Jaguars Game?

The Buffalo Bills vs. Jacksonville Jaguars game is at 1:00 PM ET on Sunday, January 11th.

Where is the Buffalo Bills vs. Jacksonville Jaguars Game Being Played?

This game will be played at EverBank Stadium in Jacksonville, Fla.

How Can I Watch Buffalo Bills vs. Jacksonville Jaguars?

You can watch Buffalo Bills vs. Jacksonville Jaguars on CBS.

Can the Jaguars Beat the Bills?

Of course! The Jacksonville Jaguars are slight underdogs, so the oddsmakers think the Bills will win but anything can happen in the NFL.

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson