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Featured Last Updated Jan 2 2026, 11:30 AM

NFL: Seahawks vs. 49ers, Prediction, Odds

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Seahawks vs. 49ers, Prediction, Odds

Featured Image Credit: Kyle Terada via Imagn Images

SEA @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 +105 + -0.5 +105 + -0.5 -105 + -1.5 +113 + -1.5 +110 + -0.5 +105 + -0.5 -110 + -1.5 +105 + -2.5 -115  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -125 + +0.5 -125 + +0.5 -115 + +1.5 -137 + +1.5 -135 + +0.5 -125 + +0.5 -110 + +1.5 -130 + +2.5 -105  
Seattle Seahawks 361 Seahawks
o44.5 -115 o23.5 -115 + o23.5 -115 + o23.5 -112 + o23.5 -113 + o23.5 -110 + o23.5 -110 + o24.5 +110 + o23.5 -113 + o47.5 -112  
San Francisco 49ers 362 49ers
u44.5 -105 u23.5 -105 + u23.5 -105 + u23.5 -108 + u23.5 -107 + u23.5 -110 + u23.5 -110 + u24.5 -135 + u23.5 -110 + u47.5 -108  
Seattle Seahawks 361 Seahawks
+164 -115 + -115 + -122 + -124 + -120 + N/A -130 + -129 + -142  
San Francisco 49ers 362 49ers
-198 -105 + -105 + +102 + +103 + -102 + N/A +110 + +104 + +120  
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 +125 + -0.5 +135 + -0.5 +124 + N/A -1.5 +144 + -0.5 +140 + -0.5 +125 + -1.5 +138 + -2.5 -115  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -150 + +0.5 -175 + +0.5 -148 + N/A +1.5 -178 + +0.5 -170 + +0.5 -150 + +1.5 -175 + +2.5 -105  
Seattle Seahawks 361 Seahawks
o44.5 -115 o9.5 -125 + o9.5 -115 + o9.5 -112 + N/A o9.5 -118 + o9.5 -115 + o8.5 -135 + o9.5 -124 + o47.5 -112  
San Francisco 49ers 362 49ers
u44.5 -105 u9.5 +105 + u9.5 -110 + u9.5 -108 + N/A u9.5 -100 + u9.5 -105 + u8.5 even + u9.5 even + u47.5 -108  
Seattle Seahawks 361 Seahawks
+164 -125 + -110 + -125 + N/A -114 + N/A -130 + -122 + -142  
San Francisco 49ers 362 49ers
-198 +105 + -110 + +105 + N/A -106 + N/A even + -103 + +120  
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 -105 + N/A -1.5 -105 + N/A -1.5 +105 + N/A N/A -1.5 +108 + -2.5 -115  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -115 + N/A +1.5 -125 + N/A +1.5 -125 + N/A N/A +1.5 -136 + +2.5 -105  
Seattle Seahawks 361 Seahawks
o44.5 -115 o23 -110 + N/A o23.5 -105 + N/A o23.5 -100 + o23.5 -115 + N/A o23.5 -110 + o47.5 -112  
San Francisco 49ers 362 49ers
u44.5 -105 u23 -110 + N/A u23.5 -115 + N/A u23.5 -120 + u23.5 -115 + N/A u23.5 -113 + u47.5 -108  
Seattle Seahawks 361 Seahawks
+164 -115 + N/A -140 + N/A -126 + N/A N/A -125 + -142  
San Francisco 49ers 362 49ers
-198 -105 + N/A +110 + N/A +108 + N/A N/A even + +120  
Seattle Seahawks 361 Seahawks
+4.5 -110 N/A N/A -0.5 +105 + N/A -1.5 +120 + -0.5 +110 + N/A N/A -2.5 -115  
San Francisco 49ers 362 49ers
-4.5 -110 N/A N/A +0.5 -135 + N/A +1.5 -146 + +0.5 -140 + N/A N/A +2.5 -105  
Seattle Seahawks 361 Seahawks
o44.5 -115 o14 -110 + N/A o13.5 -125 + N/A o14.5 -100 + o13.5 -125 + N/A N/A o47.5 -112  
San Francisco 49ers 362 49ers
u44.5 -105 u14 -110 + N/A u13.5 -105 + N/A u14.5 -122 + u13.5 -105 + N/A N/A u47.5 -108  
Seattle Seahawks 361 Seahawks
+164 -120 + N/A -125 + N/A -120 + N/A N/A N/A -142  
San Francisco 49ers 362 49ers
-198 even + N/A -105 + N/A -102 + N/A N/A N/A +120  
Seattle Seahawks 361 Seahawks
+4.5 -110 N/A N/A -0.5 +110 + N/A -1.5 +130 + -0.5 +115 + N/A N/A -2.5 -115  
San Francisco 49ers 362 49ers
-4.5 -110 N/A N/A +0.5 -140 + N/A +1.5 -160 + +0.5 -150 + N/A N/A +2.5 -105  
Seattle Seahawks 361 Seahawks
o44.5 -115 o10 -110 + N/A o9.5 -135 + N/A o9.5 -118 + o9.5 -130 + N/A N/A o47.5 -112  
San Francisco 49ers 362 49ers
u44.5 -105 u10 -110 + N/A u9.5 +105 + N/A u9.5 -104 + u9.5 even + N/A N/A u47.5 -108  
Seattle Seahawks 361 Seahawks
+164 -120 + N/A -135 + N/A -122 + N/A N/A N/A -142  
San Francisco 49ers 362 49ers
-198 even + N/A +105 + N/A -100 + N/A N/A N/A +120  
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 +120 + N/A -0.5 -105 + N/A -1.5 +126 + -0.5 -110 + N/A N/A -2.5 -115  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -140 + N/A +0.5 -125 + N/A +1.5 -156 + +0.5 -120 + N/A N/A +2.5 -105  
Seattle Seahawks 361 Seahawks
o44.5 -115 o13 -110 + N/A o13.5 -105 + N/A o13.5 -104 + o13.5 -110 + N/A N/A o47.5 -112  
San Francisco 49ers 362 49ers
u44.5 -105 u13 -110 + N/A u13.5 -125 + N/A u13.5 -118 + u13.5 -120 + N/A N/A u47.5 -108  
Seattle Seahawks 361 Seahawks
+164 -115 + N/A -135 + N/A -122 + N/A N/A N/A -142  
San Francisco 49ers 362 49ers
-198 -105 + N/A +105 + N/A -100 + N/A N/A N/A +120  

The Seahawks will take on the 49ers in this week's NFL action. Kickoff is set for 8:00 p.m. EST at Levi's Stadium in Santa Clara, Calif. The game will be broadcast live on ABC/ESPN. Here's everything you need to know about Seahawks vs. 49ers odds, the latest NFL spreads, NFL over/unders and more.

The Seahawks opened as a -1.5 point favorite over 49ers. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 1/2/26

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Seattle Seahawks vs. San Francisco 49ers Best Bet

It's tough to bet against this 49ers offense. They've been a machine since Purdy came back into the lineup.

Conversely, ever since Fred Warner and Nick Bosa went down, this defense has been limping to the finish line.

San Francisco has struggled against heavier offenses in terms of personnel and Seattle loves to operate out of 12p (1 running back, 2 tight ends). Their run game has taken some real strides over the last few weeks.

Both offenses should have natural answers.

Seahawks vs. 49ers Best Bet: Over 47.5

(Pick from Derek Mountain)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Seattle Seahawks vs. San Francisco 49ers Game?

The Seattle Seahawks vs. San Francisco 49ers is at 8:00 PM ET on Saturday, January 3rd.

Where is the Seattle Seahawks vs. San Francisco 49ers Game Being Played?

This game will be played at Levi's Stadium in Santa Clara, CA.

How Can I Watch Seattle Seahawks vs. San Francisco 49ers?

You can watch Seahawks vs. 49ers on ABC/ESPN.

Can the 49ers Beat the Seahawks?

Yes, the game is being priced as practically a pick 'em with the 49ers as a short 1-point underdog.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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