Sign Up Subscribe
Featured

NFL: Seahawks vs. 49ers, Prediction, Odds

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
NFL: Seahawks vs. 49ers, Prediction, Odds

Featured Image Credit: Kyle Terada via Imagn Images

SEA @ SF Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 -110 -0.5 -105 -1.5 -110 -1.5 +106 -1.5 -100 -1.5 -125 -4.5 even -1.5 +102 -2.5 -120  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -110 +0.5 -115 +1.5 -110 +1.5 -136 +1.5 -120 +1.5 -105 +4.5 -130 +1.5 -127 +2.5 even  
Final
Seattle Seahawks 361 Seahawks
o44.5 -115 o24 -110 o23.5 -120 o23.5 -122 o23.5 -125 o24.5 +105 o25.5 even o24.5 +105 o23.5 -115 o48.5 -110  
San Francisco 49ers 362 49ers
u44.5 -105 u24 -110 u23.5 even u23.5 +102 u23.5 -102 u24.5 -125 u25.5 -130 u24.5 -155 u23.5 -108 u48.5 -110  
Final
Seattle Seahawks 361 Seahawks
+164 -135 -130 -148 -136 -138 N/A -280 -134 -155  
San Francisco 49ers 362 49ers
-198 +115 +110 +124 +107 +112 N/A +185 +107 +130  
Final
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 +120 -0.5 +130 -0.5 +124 N/A -1.5 +132 -0.5 -110 -4.5 +150 -1.5 +135 -2.5 -120  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -140 +0.5 -170 +0.5 -148 N/A +1.5 -166 +0.5 -120 +4.5 -200 +1.5 -175 +2.5 even  
Final
Seattle Seahawks 361 Seahawks
o44.5 -115 o9.5 -120 o9.5 -115 o9.5 -112 N/A o9.5 -128 o9.5 -135 o8.5 -130 o9.5 -125 o48.5 -110  
San Francisco 49ers 362 49ers
u44.5 -105 u9.5 even u9.5 -110 u9.5 -108 N/A u9.5 +104 u9.5 +105 u8.5 -110 u9.5 even u48.5 -110  
Final
Seattle Seahawks 361 Seahawks
+164 -125 -125 -125 N/A -122 N/A -525 -124 -155  
San Francisco 49ers 362 49ers
-198 +105 +105 +105 N/A -102 N/A +320 even +130  
Final
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 -110 N/A -1.5 +110 N/A -1.5 -100 N/A -0.5 +110 -1.5 +105 -2.5 -120  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -110 N/A +1.5 -140 N/A +1.5 -120 N/A +0.5 -145 +1.5 -130 +2.5 even  
Final
Seattle Seahawks 361 Seahawks
o44.5 -115 o23 -110 N/A o23.5 -120 N/A o23.5 -110 o23.5 -115 o22.5 -145 o23.5 -112 o48.5 -110  
San Francisco 49ers 362 49ers
u44.5 -105 u23 -110 N/A u23.5 even N/A u23.5 -110 u23.5 -115 u22.5 even u23.5 -112 u48.5 -110  
Final
Seattle Seahawks 361 Seahawks
+164 -130 N/A -125 N/A -134 N/A -110 -130 -155  
San Francisco 49ers 362 49ers
-198 +110 N/A -105 N/A +114 N/A -130 +105 +130  
Final
Seattle Seahawks 361 Seahawks
+4.5 -110 N/A N/A -0.5 +110 N/A -1.5 +110 -0.5 +105 -0.5 -105 N/A -2.5 -120  
San Francisco 49ers 362 49ers
-4.5 -110 N/A N/A +0.5 -140 N/A +1.5 -134 +0.5 -135 +0.5 -125 N/A +2.5 even  
Final
Seattle Seahawks 361 Seahawks
o44.5 -115 o14.5 -105 N/A o14.5 -105 N/A o9.5 -110 o14.5 -110 o14.5 -115 N/A o48.5 -110  
San Francisco 49ers 362 49ers
u44.5 -105 u14.5 -115 N/A u14.5 -125 N/A u9.5 -120 u14.5 -120 u14.5 -125 N/A u48.5 -110  
Final
Seattle Seahawks 361 Seahawks
+164 -140 N/A -120 N/A -138 N/A -140 N/A -155  
San Francisco 49ers 362 49ers
-198 +120 N/A -110 N/A +112 N/A +105 N/A +130  
Final
Seattle Seahawks 361 Seahawks
+4.5 -110 N/A N/A -0.5 +110 N/A -1.5 +124 +0.5 -140 +1.5 -150 N/A -2.5 -120  
San Francisco 49ers 362 49ers
-4.5 -110 N/A N/A +0.5 -140 N/A +1.5 -154 -0.5 +110 -1.5 +115 N/A +2.5 even  
Final
Seattle Seahawks 361 Seahawks
o44.5 -115 o10 -105 N/A o9.5 -140 N/A o0.5 +320 o9.5 -130 o8.5 -155 N/A o48.5 -110  
San Francisco 49ers 362 49ers
u44.5 -105 u10 -115 N/A u9.5 +110 N/A u0.5 -480 u9.5 even u8.5 +105 N/A u48.5 -110  
Final
Seattle Seahawks 361 Seahawks
+164 -130 N/A -145 N/A -138 N/A +105 N/A -155  
San Francisco 49ers 362 49ers
-198 +110 N/A +114 N/A +108 N/A -140 N/A +130  
Final
Seattle Seahawks 361 Seahawks
+4.5 -110 -0.5 +115 N/A -0.5 -110 N/A -1.5 +122 -0.5 -105 -0.5 +110 N/A -2.5 -120  
San Francisco 49ers 362 49ers
-4.5 -110 +0.5 -135 N/A +0.5 -120 N/A +1.5 -146 +0.5 -125 +0.5 -145 N/A +2.5 even  
Final
Seattle Seahawks 361 Seahawks
o44.5 -115 o13 -110 N/A o13.5 -120 N/A o13.5 -108 o13.5 -110 o12.5 -155 N/A o48.5 -110  
San Francisco 49ers 362 49ers
u44.5 -105 u13 -110 N/A u13.5 -110 N/A u13.5 -110 u13.5 -120 u12.5 +105 N/A u48.5 -110  
Final
Seattle Seahawks 361 Seahawks
+164 -120 N/A -140 N/A -128 N/A -120 N/A -155  
San Francisco 49ers 362 49ers
-198 even N/A +110 N/A +104 N/A -115 N/A +130  

The Seahawks will take on the 49ers in this week's NFL action. Kickoff is set for 8:00 p.m. EST at Levi's Stadium in Santa Clara, Calif. The game will be broadcast live on ABC/ESPN. Here's everything you need to know about Seahawks vs. 49ers odds, the latest NFL spreads, NFL over/unders and more.

The Seahawks opened as a -1.5 point favorite over 49ers. The total is set at over/under 49.5 total points scored by both teams combined.

Be sure to check out the latest NFL odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 2/21/26

bet365
Bet $5, Get $150 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $150
Deposit Required. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New Customers Only. T&Cs, time limits, and exclusions apply. 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, MO, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $150 in Bonus Bets at bet365. Minimum odds -500 of greater.

Seattle Seahawks vs. San Francisco 49ers Best Bet

It's tough to bet against this 49ers offense. They've been a machine since Purdy came back into the lineup.

Conversely, ever since Fred Warner and Nick Bosa went down, this defense has been limping to the finish line.

San Francisco has struggled against heavier offenses in terms of personnel and Seattle loves to operate out of 12p (1 running back, 2 tight ends). Their run game has taken some real strides over the last few weeks.

Both offenses should have natural answers.

Seahawks vs. 49ers Best Bet: Over 47.5

(Pick from Derek Mountain)

Looking for more best bets? Check out our free NFL picks and our premium subscription for the best picks!

What Time is the Seattle Seahawks vs. San Francisco 49ers Game?

The Seattle Seahawks vs. San Francisco 49ers is at 8:00 PM ET on Saturday, January 3rd.

Where is the Seattle Seahawks vs. San Francisco 49ers Game Being Played?

This game will be played at Levi's Stadium in Santa Clara, CA.

How Can I Watch Seattle Seahawks vs. San Francisco 49ers?

You can watch Seahawks vs. 49ers on ABC/ESPN.

Can the 49ers Beat the Seahawks?

Yes, the game is being priced as practically a pick 'em with the 49ers as a short 1-point underdog.

Featured News

Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
•