NFL Divisional Round Odds: Lines, Spreads, Betting Trends for All Four Playoff Games

Patrick Everson Sports Betting Expert

3 minute read

NFL Divisional Round odds are more of a mirage at the moment, with only four of eight teams set. All four matchups remain up in the air.

What is known: The NFC No. 1 seed Seattle Seahawks and AFC No. 1 seed Denver Broncos are at home. And the No. 5 Los Angeles Rams and No. 2 Chicago Bears also claimed spots on the NFL Divisional Playoff odds board.

Here’s everything you need to know about the NFL odds Divisional Playoff market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Divisional Round odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Ron Chenoy/Imagn Images)

2025-26 NFL Playoff Odds for Divisional Round

Los Angeles Rams/San Francisco 49ers vs. Seattle Seahawks Odds

• Opening point spread: Seahawks TBA
• Opening moneyline: Rams-49ers TBA/Seahawks TBA
• Opening total: Over/Under TBA points scored
• Time: TBA

OPENING ODDS UPDATE: Seattle (14-3 SU/12-5 ATS) grabbed the No. 1 seed with an impressive defensive showing in Week 18. The Seahawks shut down San Francisco 13-3, laying 3.5 points at home.

Seattle tied for both the NFL's best SU record and best ATS mark.

In NFL Divisional Round odds, Seattle meets the lowest remaining NFC seed from Wild Card Weekend. That will be either No. 5 Los Angeles (13-5 SU/11-7 ATS) or No. 6 San Francisco (12-5 SU/11-6 ATS).

The fifth-seeded Rams outlasted Carolina 34-31 as 10-point road favorites in Saturday's first Wild Card game. The sixth-seeded Niners visit Philadelphia on Sunday.

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Los Angeles Rams/San Francisco 49ers vs. Chicago Bears Odds

• Opening point spread: TBA
• Opening moneyline: Rams-49ers TBA/Bears TBA
• Opening total: Over/Under TBA points scored
• Time: TBA

OPENING ODDS UPDATE: Chicago (12-6 SU/11-6-1 ATS) was at elimination's doorstep in the Wild Card Round on Saturday night, trailing Green Bay 21-3 at halftime. But the Bears scored 25 fourth-quarter points in a wild 31-27 victory as 1.5-point home underdogs.

Caleb Williams threw a 25-yard TD pass to D.J. Moore with 1:43 remaining. The Bears then kept the Packers out of the end zone on a last-gasp final drive.

In NFL Divisional Playoff odds, the Bears face either the Los Angeles Rams (13-5 SU/11-7 ATS) or San Francisco 49ers (12-5 SU/11-6 ATS), depending on Sunday's results.

As noted above, the Rams edged Carolina on Saturday, and the Niners visit Philadelphia on Sunday.

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Buffalo Bills/Los Angeles Chargers vs. Denver Broncos Odds

• Opening point spread: TBA
• Opening moneyline: Bills-Chargers TBA/Broncos TBA
• Opening total: Over/Under TBA points scored
• Time: TBA

OPENING ODDS UPDATE: Denver (14-3 SU/7-10 ATS) got the No. 1 seed and the bye in the AFC with a relatively easy Week 18 win. The Broncos closed as 14.5-point home favorites vs. a Chargers team resting players, and Denver won 19-3.

That ended a 1-4 ATS slide for the spread-covering-challenged Broncos.

In NFL Divisional Round odds, Denver faces the lowest remaining AFC seed from Wild Card Weekend. That will be either the No. 6 Buffalo Bills (13-5 SU/9-9 ATS) or No. 7 Los Angeles Chargers (11-6 SU/9-8 ATS).

The Bills won a Wild Card thriller at Jacksonville to kick off Sunday action. In a fourth quarter featuring four lead changes, Buffalo came out on top 27-24 as a 1.5-point road underdog.

A pair of Josh Allen runs on the Bills' final two plays – the first for 10 yards on a huge fourth-and-1 – put Buffalo ahead with 1:04 remaining. The Bills sealed it with an interception off a deflected Trevor Lawrence pass.

For the moment, Buffalo is Denver's opponent. If the Chargers beat New England on Sunday night, then L.A. travels to Denver instead.

TBA vs. TBA Odds

(TBA Teams: Patriots, Jaguars, Steelers, Texans, Bills)

• Opening point spread: TBA
• Opening moneyline: TBA
• Opening total: Over/Under TBA points scored
• Time: TBA

OPENING ODDS UPDATE: If seeding holds on Wild Card Weekend, then the No. 2 seed New England Patriots (14-3 SU/12-5 ATS) will be the home team in this matchup.

However, with all three AFC matchups still to come in the NFL Wild Card Odds market, anything could happen on Sunday/Monday. Check back for more on this matchup in NFL Divisional Playoff odds.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson