NFL Odds Week 3: Bills vs Commanders Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline

Week 3 of the NFL season is in high gear, with the spotlight firmly on the odds in this season's action-packed battles. The surprising Commanders seek a 3-0 start as they host the Bills on Sunday, September 24 at 1:00 p.m. ET on CBS.

Here's everything you need to know about the NFL odds for the Week 3 game between the Bills and Commanders: the opening lines, spreads, betting trends and more. Check back regularly for updates.

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Buffalo Bills vs Washington Commanders Odds

The Commanders seek a 3-0 start as they host the Bills on Sunday. (Getty)
  • Opening point spread: Bills -6.5
  • Opening moneyline: Bills -310/Commanders +250
  • Opening total: Over/Under 45.5 points scored
  • Time: 1 p.m. ET Sunday (CBS)

UPDATE 10:15 A.M. ET SUNDAY: Buffalo is down to -5.5 at BetMGM, after opening -6.5 and briefly touching -7 Monday. Still, tickets and money are just shy of 2/1 on the Bills.

As was the case Friday (see below), the total is at 43 from a 45.5 opener. There could be a little rain today. That said, tickets and money are about 2/1 on the Over at BetMGM.

UPDATE 2:30 P.M. ET FRIDAY: The Bills have spent almost all week as 6.5-point favorites at BetMGM, save for about three hours Monday at -7. Buffalo is netting 66% of early spread bets/60% of early spread dollars.

The total opened at 45.5 and steadily made its way down to 43 by Thursday. That said, tickets and money are in the 2/1 range on the Over.

UPDATE 9:30 P.M. ET SUNDAY: After getting stunned by an ostensibly Aaron Rodgers-less Jets squad in Week 1, Buffalo didn't mess around in Week 2. The Bills (1-1 SU and ATS) rocked the Raiders 38-10, easily cashing as 7.5-point home favorites.

Washington is somehow 2-0 SU (1-1 ATS). After a lackluster Week 1 win over Arizona, the Commanders fell into a 21-3 second-quarter hole at Denver. But Washington then scored 32 of the next 35 points and held on for a stunning 35-33 win catching 3.5 points.

The Bills-Commanders line and total are stable tonight in The SuperBook's NFL Week 3 odds market.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 3 Report containing spreads, lines, and trends for every NFL matchup.

Bills vs Commanders Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

We don't get many home 2-0 underdogs of six or more points like Washington, but they've performed well over the last two decades at 7-2 ATS.

A weekend tropical storm headed to the East Coast could have a direct impact on this game, with conditions making passing and scoring difficult.

Washington is 2-0 but eked out late comeback wins over a pair of 0-2 teams, Arizona and Denver. The comeback counts, but so does the big hole they built to start with. Sam Howell made some throws but is still struggling with pocket presence.

Hey, you know who's better than Sam Howell? Josh Allen! The Bills looked just fine last week after shaking off Week 1, and you already know the stat: Buffalo has won by at least eight points in 28 of its last 32 wins (88%). When the Bills win, they win big.

Pick: Bills -6.5 (-110)

For more NFL Week 3 picks, check out Action Network's NFL Week 3: How to Bet Every Game & Every Team.

The One Stat to Know About Bills vs Commanders

Action Network NFL researcher Evan Abrams offers his top betting stat:

Josh Allen has 57 wins in his career. 43 of those 57 wins have come by seven points or more.

For more NFL Week 3 picks, check out Action Network's NFL Week 3 Betting Trends, Stats, Notes.

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  • Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
  • Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
  • Check out the North Carolina Sportsbooks just before they launch legal online sports betting.