NFL Odds Week 4: Rams vs Colts Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

3 minute read

Week 4 of the NFL highlights an interconference battle in Indianapolis between the Rams and surprising Colts. L.A. and Indy kick off on Sunday, October 1 at 1:00 p.m. ET on FOX.

Here's everything you need to know about the NFL odds for Week 4 Rams vs Colts: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Los Angeles Rams vs Indianapolis Colts Odds

• Opening point spread: Pick
• Opening moneyline: Rams -110/Colts -110
• Opening total: Over/Under 45 points scored
• Time: 1 p.m. ET Sunday (FOX)

UPDATE 12:30 P.M. ET SUNDAY: After the Colts spent all week as a short favorite at BetMGM, the line flipped this morning to Rams -1. Los Angeles is seeing 61% of spread tickets/62% of spread dollars.

The total opened at 45, topped out at 46.5 Tuesday, then made its way down to 44.5 by late this morning. Still, tickets and money are in the 4/1 range on the Over.

UPDATE 12:30 P.M. ET FRIDAY: Indy has been the shortest of favorites all week at BetMGM. After opening -1, the Colts crept to -1.5 late Monday night, then returned to -1 Tuesday morning. The line has been at Indianapolis -1 (-105) since Wednesday evening.

Short 'dog Los Angeles is drawing 58% of early spread bets/67% of early spread dollars.

The total dipped from 45 to 44.5 Tuesday, but rebounded within a few hours to 46.5. It's been at 45.5 since Thursday morning, with tickets running 4/1 and money almost 6/1 on the Over.

UPDATE 10 P.M. ET SUNDAY: Indianapolis notched a notable upset in Week 3, helping kill a bundle of moneyline parlays/teasers for public/recreational bettors. The Colts closed as 7.5-point pups at Baltimore and won 22-19 on a field goal with 1:09 left in overtime.

Los Angeles still has Week 3 work to do. The Rams (1-1 SU/2-0 ATS) travel to Cincinnati for a Monday night tilt.

Click here for Vegas Insider senior reporter Patrick Everson's full NFL Odds Week 4 Report containing spreads, lines, and trends for every NFL matchup.

Rams vs Colts Pick, Prediction

Action Network NFL betting expert Brandon Anderson offers this prediction:

Jonathan Taylor is set to come off the IR next week but reportedly doesn't want to come back. With the way Zack Moss is running, the Colts may not force the issue. Moss ran 30 times for 122 yards last week after debuting Week 2 with 18 rushes for 88.

It's more brutally efficient than pretty, but Moss is getting the job done and has established himself as the clear lead back. The Rams rank 29th in Rushing DVOA and just got gashed by the Eagles Monday night, so Moss should get to this number with ease. If you're into it and ready to punt Taylor to the curb, Moss is still +3000 to lead the league in rushing yards too.

Pick: Zack Moss Over 66.5 Rushing Yards (-115)

For more NFL Week 4 picks, check out Action Network's NFL Week 4: How to Bet Every Game & Every Team.

The One Stat to Know About Rams vs Colts

Action Network NFL researcher Evan Abrams offers his top betting stat:

Stafford hasn’t finished above .500 ATS in a season since 2018 – he was 2-6-1 ATS last year, worst season since 2013.

For more NFL Week 4 picks, check out Action Network's NFL Week 4 Betting Trends, Stats, Notes.

Where to place a bet this NFL Season?

• Use our exclusive BetMGM Bonus Code VIBONUS1500 to unlock BetMGM’s welcome offer for new sportsbook users!
• Compare the latest NFL Odds from the best sportsbooks before placing a bet on this week's games.
• Check out the North Carolina Sportsbooks just before they launch legal online sports betting.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson