Last Updated Oct 09, 2022, 9:02 PM

NFL Week 2 Opening Odds Report

NFL Week 2 odds reveal a very enticing Thursday night matchup, arguably the game of the week. The Kansas City Chiefs play host to the Los Angeles Chargers, an early-season AFC West battle between two teams harboring Super Bowl hopes.

Plus, the Dallas Cowboys will be down Dak Prescott, which jolted the Week 2 NFL odds market.

Multiple oddsmakers provide insights on NFL Week Two odds and action. Check back regularly for updates.

NFL Week 2 Odds

Tennessee Titans at Buffalo Bills

Josh Allen, right, and his Bills teammates were all smiles in a win over the Rams. (Getty)

Opening line: Titans -9; Over/Under 50.5
Time: 7:15 p.m. ET Monday (ESPN)

UPDATE 6:45 P.M. ET MONDAY: Thirty minutes pre-kick, Buffalo is laying 10 points at WynnBet, which is where the number has been all week. The Bills are drawing just 60% of spread bets, but that's translating to 75% of spread dollars.

Further, bettors are on Bills moneyline, even at the hefty price of -475. Tickets are 5/1 and money 2.5/1 on Buffalo.

The total quickly dipped from 50.5 to 49.5, then to 48.5 midweek. On Friday, it bottomed out at 47.5, and on Sunday night, it rose to 48. This morning, the total backed up to 47.5 again. Ticket count is almost 2/1 on the Over, but money is almost 4/1 on the Under.

UPDATE 1:30 P.M. ET MONDAY: A few hours before kickoff, the Bills are 10-point favorites in PointsBet USA's NFL Week 2 odds market. That's up a tick from the -9.5 opener and a point from the early-week low of -9, and down a half-point from the -10.5 peak Wednesday.

Over the past few days, the line has toggled between Buffalo -10 and -9.5 several times. Point-spread ticket count is 2.5/1 and point-spread money 3/1 on Buffalo. Further, PointsBet customers aren't shying away from Buffalo's hefty -450 moneyline price, with a vast majority of tickets/cash on the Bills.

The total opened at 50, dipped to 48 by Wednesday, 47.5 Friday and 47 Sunday. It rebounded to 48 late Sunday night, then went to 47.5 this morning. The Over is seeing 59% of tickets, while 67% of money is on the Under.

UPDATE 2 P.M. ET WEDNESDAY: This Monday night matchup is among a few big spreads on the NFL Week 2 odds board. At DraftKings, Buffalo toggled between the -9.5 opener and -10 a couple of times on Monday and Tuesday. This morning, the Bills briefly touched -10.5, and they're now -10.

Buffalo is drawing 70% of early spread tickets and 82% of early spread cash.

The total opened at 50, spent most of the last couple of days at 49.5, and went to 49 this morning. DraftKings is seeing 55% of early bets on the Over, but 68% of early cash on the Under.

UPDATE MIDNIGHT ET SUNDAY: Buffalo (1-0 SU and ATS) was a little rusty in the first half against the defending Super Bowl champion Los Angeles Rams. But Josh Allen and Co. cranked it up in the second half and rolled 31-10 laying 2.5 points on the road.

Meanwhile, Tennessee (0-1 SU and ATS) stubbed its toe at home, letting a 13-0 halftime lead slip away against the New York Giants. The Titans, giving 5.5 points, ultimately lost 21-20 on a late Giants touchdown and 2-point conversion.

Titans-Bills is the first of two Monday night games in the NFL Week 2 odds market.

"We opened the Bills -9, and the Bills are already seeing more action than any other Week 2 side," Murray said. "I’d expect that to continue throughout the week, considering the incredible performance from Buffalo this past Thursday, and the Titans huge meltdown at home. The Bills will be in every teaser and moneyline parlay that's coming. And that's probably something we will be dealing with all season."

Later Sunday evening, The SuperBook moved Buffalo out to -9.5. The total dipped a point to 49.5.

Minnesota Vikings at Philadelphia Eagles

Opening line: Eagles -3; Over/Under 48.5
Time: 8:30 p.m. ET Monday (ABC)

UPDATE 7:30 P.M. ET MONDAY: The Eagles hit WynnBet's NFL Week 2 odds board as a 2.5-point home favorite. Philly then dipped to -2 last Monday, returned to -2.5 Sunday morning, and in the past hour rose to -3 (-105).

Still, it's two-way action, with 55% of spread bets on Minnesota and 57% of spread money on Philly. And bettors like the short 'dog Vikings +135 on the moneyline, where tickets and cash are running about 2/1 Minnesota.

The total opened at 50, peaked at 51 a week ago, then spent most the week at 50.5. As kickoff looms, it's now at 50 again, with 64% of tickets on the Over/54% of money on the Under.

UPDATE 1:30 P.M. ET MONDAY: This matchup is much more balanced at PointsBet than the the Titans-Bills affair. Philly is a 2.5-point favorite today, after opening -3 a week ago and bottoming out at -1.5 within a few hours last Monday.

The line spent the rest of the week bouncing between -2 and -2.5 several times, before setting at -2.5 Saturday afternoon. Minnesota is taking 57% of spread bets, and Philadelphia is seeing 63% of spread dollars.

The total opened at 49.5, peaked at 51.5 multiple times early on, then spent much of the past week at 50.5. This morning, the total dipped to 49.5, then went to 49 at lunch hour. However, ticket count is just shy of 2/1 and money is 3/1 on the Over.

UPDATE 2 P.M. ET WEDNESDAY: This line has bounced around a bit at DraftKings. After opening Philly a 2.5-point chalk, the initial move Sunday night was to Philly -3. By Monday afternoon, the Eagles were down to -1.5, but by Tuesday afternoon rebounded to -2.5, where the number sits now.

Still, the visiting Vikings are attracting 70% of early tickets/66% of early dollars on the spread.

The total opened at 48.5 and made its way to 51.5 by Monday afternoon. By Tuesday night, the total backed up to 49.5, then early today got to 50.5. Ticket count is 3/1 and money 7/1 on the Over.

UPDATE MIDNIGHT ET SUNDAY: Minnesota (1-0 SU and ATS) notched a solid Week 1 win over archrival Green Bay. The Vikings, who closed as 2-point home favorites, rolled to a 23-7 victory.

Philadelphia (1-0 SU, 0-1 ATS) was coasting to victory, as well, leading 38-21 through three quarters at Detroit. The Eagles let the Lions make a run, but hung on 38-35 while failing to cover as 5.5-point faves.

Vikings-Eagles proved one of the more challenging lines to set on the NFL Week 2 odds board.

"We went back and forth on this one, with the room split between Eagles -2.5 and Eagles -3," Murray said. "Both teams were impressive, although the Eagles did let the Lions back into the game and into the back door for a cover. We’ve seen a few guys take the +3 (-110) with the Vikings, but nothing that’s caused us to move the number yet. This should be a good two-way game."

Late tonight, the spread remained Eagles -3, and the total was up a tick to 49. Vikings-Eagles is the second of two Monday night games in Week 2.

Chicago Bears at Green Bay Packers

Justin Fields and the Bears scored a Week 1 upset against the visiting 49ers. (Getty)

Opening line: Packers -9; Over/Under 45.5
Time: 8:20 p.m. ET Sunday (NBC)

UPDATE 7:45 P.M. ET SUNDAY: About a half hour before kickoff, Green Bay is a 10-point chalk at WynnBet, after opening -8.5. Chicago is actually netting a slim majority 53% of spread bets, but the Packers are seeing 63% of spread money.

Regardless, WynnBet said it's in a good position for Sunday Night Football, thanks to the Cardinals' road upset of the Raiders in overtime. Arizona surely killed plenty of parlays and moneyline parlays tying the Raiders to the Packers.

The total is down to 41.5 from a 44 opener, with the Under getting only 53% of tickets, but those tickets translating to a hefty 84% of money on the Under.

UPDATE 10:30 A.M. ET SUNDAY: Green Bay opened -9.5 on Caesars Sports' NFL Week 2 odds board and initially backed up to -9 Monday morning. But that didn't last long, as the Packers quickly moved up to -9.5 and then -10, where they've spent most of the week.

However, the Bears are actually taking 63% of spread tickets for the Sunday Night Football clash. The Packers are are netting 62% of spread dollars.

The total opened at 44.5 and bottomed out at 41.5, where it's been since Wednesday night. Caesars books are seeing 55% of tickets on the Over, but 75% of cash on the Under.

UPDATE 11:30 P.M. ET WEDNESDAY: On Sunday night, the Packers opened as 9.5-point favorites at DraftKings. The line went to Green Bay -10 Monday morning and stuck there until very early today, when it dipped to Pack -9.5 (-115). The number then went to -10 again this afternoon, before returning to -9.5 (-115) late tonight

DraftKings is seeing 76 % of early spread tickets and 57% of early spread cash on the underdog Bears.

The total opened at 44 on Sunday evening and steadily made its way down to 41.5 by late this evening. The Under is taking 56% of bets/57% of money early on.

UPDATE MIDNIGHT ET SUNDAY: Chicago (1-0 SU and ATS) was one of the Week 1 surprises, albeit it in a monsoon at Soldier Field. Justin Fields and the Bears slogged their way to a 19-10 upset of San Francisco, winning outright as 6.5-point underdogs.

Green Bay (0-1 SU and ATS) was among the Week 1 disappointments, even after going off as a 2-point road 'dog at Minnesota due to late-breaking injury news. The Packers got only a third-quarter touchdown in a 23-7 loss. Wideout Allen Lazard, and offensive lineman David Bakhtiari and Elgton Jenkins sat out.

There was early interest in Bears-Packers at The SuperBook, but not on the spread.

"The sharp money came quickly on the Under, and we knocked the total down a point to 44.5," Murray said, before noting this week's Sunday nighter became more of a key game due to Week 1 results. "All of a sudden, this game is really intriguing to people who aren’t Bears or Packers fans. Chicago rallied to stun the 49ers, and the Packers looked like the Packers we saw in Week 1 last year (vs. Saints). I still believe Aaron Rodgers will be fine. Minnesota is better than people realize."

While the total dipped a point, the line was stable tonight at Packers -9.

Cincinnati Bengals at Dallas Cowboys

Cowboys QB Dak Prescott could miss several weeks with a thumb injury. (Getty)

Opening line: Cowboys -2/total 51
Time: 4:25 p.m. ET Sunday (CBS)

UPDATE 3:15 P.M. ET SUNDAY: Just more than an hour before kickoff, Cincinnati is a 7-point favorite in PointsBet USA's NFL Week 2 odds market. The Bengals opened -7 Monday, touched -8.5 Tuesday, and spent the past few days toggling between -7.5 and -7. The line has been stable at -7 since Saturday afternoon.

It's all Cincy on the spread, with ticket count and money both running 6/1.

The total tumbled from 44.5 to 41.5, and it's now at 42, with ticket count almost 2/1 and money 3/1 on the Over.

UPDATE 5 P.M. ET FRIDAY: PointsBet USA waited until Monday to post this line, seeking clarity on the status of Cowboys QB Dak Prescott. Early Monday afternoon, in the wake of news that Prescott could miss several weeks, PointsBet opened the Bengals -7.

By Tuesday afternoon, Cincy stretched to -8.5. Wednesday morning, the line receded to Bengals -7.5, and since then, it's toggled between -7.5 and -7. Cincinnati is currently -7 and remains a popular early play in PointsBet's NFL Week 2 odds market.

"More than 80% of the spread bet count and handle are on the Bengals," PointsBet sports analyst Mike Korn said. "Bengals moneyline is also in a ton of parlays."

On Sunday, prior to the Bucs-Cowboys game and the subsequent Prescott injury, some books opened the total at 51/51.5. But again, PointsBet held off until Monday afternoon and opened at 44.5. Since then, the total has continued to tumble, bottoming out at 41.5 a couple of times.

The total has been stable at 41.5 since Thursday afternoon. Ticket count is close, with 53% on the Over, but the Under has drawn 72% of money thus far.

UPDATE 11 P.M. ET MONDAY: DraftKings opened this matchup at Cowboys -2.5 on Sunday afternoon, hours before Dak Prescott suffered his thumb injury. So Sunday night, DraftKings took the game off the board. When the matchup reopened this morning, DK flipped all the way to Bengals -6.5.

A couple of hours later, Cincy was up to -7, and that's where the number sits late tonight. Granted, this early in the week, there's surely not that much action yet. But of what there is, ticket count and money are running 9/1 on the Bengals against the suddenly shorthanded Cowboys.

With Prescott out, obviously the total took a big dive, too. DraftKings opened at 51.5, took it off the board Sunday night, then reopened Monday morning at 44.5. That wasn't enough to keep bettors off the Under, as the total dipped to 43.5 this afternoon.

The Over is actually seeing 54% of early tickets, but 74% of early dollars are on the Under.

UPDATE MIDNIGHT ET SUNDAY: It's bad enough that Dallas (0-1 SU and ATS) managed just a field goal in its 19-3 home loss to the Tampa Bay Buccaneers. The Cowboys fell well short of covering as 2.5-point home underdogs.

But worse, Cowboys QB Dak Prescott suffered a thumb injury in the fourth quarter. Postgame, it was revealed that he'd need surgery and could miss several weeks.

Defending AFC champion Cincinnati (0-1 SU and ATS) got off to a bumpy start, too. The Bengals had five turnovers, plus a missed PAT in the final seconds of regulation and a missed field goal in overtime. If either of those connect, Cincy beats Pittsburgh. Instead, the Bengals lost 23-20 as 7-point home favorites.

"We opened the Cowboys -2 and took it down after the Sunday night game kicked off," Murray said. That's standard operating procedure at The SuperBook: When the Sunday night game starts, those two teams have their subsequent week's game taken off the board.

The SuperBook will put Bengals-Cowboys back up Monday morning with a number that will surely be miles from the Cowboys -2 opener. Multiple oddsmakers opined late Sunday night that the line could flip as far as Bengals -7.

"It still doesn’t seem possible that the Bengals lost, but all of a sudden, they’re in scramble mode," Murray said.

That scramble could be much easier against a Prescott-less Cowboys outfit.

Arizona Cardinals at Las Vegas Raiders

Opening line: Raiders -3.5; Over/Under 52.5
Time: 4:25 p.m. ET Sunday

UPDATE 3:30 P.M. ET SUNDAY: PointsBet USA tabbed Las Vegas a 3-point chalk last Sunday and, like everywhere else, quickly got to Raiders -5.5. The Raiders peaked at -6 Tuesday, then spent much of the week toggling between -5.5 and -5.

However, about 20 minutes ago, the Raiders dropped a point to -4.5. But the line returned to -5.5 in short order. It's two-way action with a lean toward the Raiders, who are taking 55% of bets/59% of money on the spread.

The total opened at 51.5, peaked at 52.5, spent most of the week back at 51.5 and just dipped to 51. Tickets and money are both about 3/2 on the Over.

UPDATE 10:30 A.M. ET SUNDAY: Las Vegas advanced from -3.5 to -4.5, -5 and -5.5 by Monday afternoon at Caesars Sports. On Tuesday, the Raiders reached -6, then on Wednesday returned to -5.5, where the line stabilized.

Point-spread ticket count is dead even at Caesars, while the Raiders are landing 57% of spread money.

The total opened at 52 but spent pretty much all week at 51.5. Ticket count is almost even, but 73% of cash is on the Over.

UPDATE 1:30 P.M. ET WEDNESDAY: This line has been a big mover since opening Raiders -3.5 Sunday night in DraftKings' NFL Week 2 odds market. Las Vegas rose to -4.5 Monday morning, -5.5 Monday afternoon and -6 early Tuesday.

Injuries are certainly part of those moves. Arizona wideout Rondale Moore (hamstring) is questionable. Cards defensive end J.J. Watt (calf) missed Sunday's blowout home loss to the Chiefs and is questionable this week.

All that noted, it's not as if the Raiders are racking up a bunch of early tickets and cash. In fact, Arizona is seeing 56% of spread bets, while Las Vegas is netting 62% of spread dollars.

The total opened at 52, dipped to 51 Monday morning, then rebounded to 52 early Tuesday. The total has been stable at 51.5 since Tuesday afternoon, with 56% of bets/73% of money on the Over.

UPDATE MIDNIGHT ET SUNDAY: Las Vegas (0-1 SU and ATS) had its chances in a Week 1 AFC West showdown against the Los Angeles Chargers. But Derek Carr threw three INTs, and the Raiders lost 24-19 as 3.5-point road pups.

By contrast, Arizona (0-1 SU and ATS) really had no chance at all against red-hot Patrick Mahomes and Kansas City. The Cardinals, catching 6 points at home, got torched 44-21.

"We opened Raiders -3.5 and are still there," Murray said. "The Cardinals' defense got shredded by Mahomes and Co. at home, and now they have to go on the road and take on the Raiders. The schedule makers didn’t do the Cardinals any favors with this start to their season. This figures to be a big-handle game in the afternoon, with us needing the Cardinals."

While the point spread held firm tonight, the total dipped a point to 51.5 at The SuperBook.

Tampa Bay Buccaneers at New Orleans Saints

Leonard Fournette rushed for 127 yards in the Buccaneers' Week 1 win. (Getty)

Opening line: Buccaneers -2.5; Over/Under 48
Time: 1 p.m. ET Sunday (FOX)

UPDATE 10:30 A.M. ET SUNDAY: The Bucs opened -2 at Caesars Sports and got to -3 by lunchtime Monday. Tampa has been at -2.5 since Wednesday morning, mostly at the flat price of -110. Tom Brady and Co. are drawing 54% of spread bets and 63% of spread money.

The total opened at 45.5 and bottomed out this morning at 43.5. Ticket count is almost even, while 64% of cash is on the Under.

UPDATE 5 P.M. ET FRIDAY: At BetMGM, this matchup is the second-most-bet game, by ticket count, on the NFL Week 2 odds board. And most of that action is going to Tampa Bay, which is drawing the third-most point-spread tickets and the most spread money of any team in Week 2.

The Bucs opened -2.5 Monday morning at BetMGM, quickly went to -3, then toggled between those two numbers until Wednesday afternoon. Since then, Tampa has been stable at -2.5. Ticket count is 2.5/1 and money is approaching 3/1 on the Buccaneers.

The total opened at 45.5, dipped to 44.5 within a few hours Monday, then went to 44 late Wednesday morning. On Thursday afternoon, the number nudged up to 44.5, but this afternoon, it returned to 44. Current splits on the total weren't available.

UPDATE 1:30 P.M. ET WEDNESDAY: The Bucs hit DraftKings' odds board at -3 (even) Sunday evening and have been at various iterations of 2.5 since Tuesday afternoon. Tampa is currently -2.5 flat (-110), with point-spread tickets running 3/1 and money just shy of 2/1 on Tom Brady and Co.

The total tumbled from Sunday night's 48 opener straight to 45.5 Monday morning, then to 44 Monday afternoon. Injuries are certainly part of the decline. Tampa Bay wideout Chris Godwin (hamstring) is listed as questionable, but multiple reports make it sound like he's at least out this week. Bucs left tackle Donovan Smith (elbow) is questionable, as is New Orleans running back Alvin Kamara (ribs).

All that noted, 71% of early bets/63% of early dollars are on the Over. However, it's very likely the bulk of those Over tickets and dollars have come in at the lower numbers, 44 and 45.5.

UPDATE MIDNIGHT ET SUNDAY: Tampa Bay (1-0 SU and ATS) didn't exactly light up the scoreboard under the bright lights of Week 1 Sunday Night Football. But the Bucs held Dallas to a first-quarter field goal. So a pedestrian effort by Tom Brady and Tampa was enough to net a 19-3 win as a 2.5-point road favorite.

New Orleans (1-0 SU, 0-1 ATS) had to rally from a 26-10 fourth-quarter deficit against unheralded Atlanta. The Saints won 27-26 on a final-seconds field goal, but failed to cash as 5.5-point faves.

"We opened the Bucs -2.5 and it’s now off the board," Murray said, noting Bucs-Saints came down once Tampa kicked off at Dallas on Sunday night. "I’m not sure what to make of either team yet. The Saints probably lose badly today if the Falcons don’t do what the Falcons always do and take their foot off the gas. We will likely need the Saints here. The public loves Tom Brady."

The line and total were unchanged in the hour or so the game was up Sunday night. Bucs-Saints will go back on the NFL Week 2 odds board Monday morning.

Los Angeles Chargers at Kansas City Chiefs

Patrick Mahomes and the Chiefs are already up to -3.5 against the visiting Chargers. (Getty)

Opening line: Chiefs -3; Over/Under 54
Time: 8:15 p.m. ET Thursday (Amazon Prime)

UPDATE 5 P.M. ET THURSDAY: With three-plus hours until kickoff, Kansas City is a 4-point chalk on WynnBet's NFL Week 2 odds board. The Chiefs opened -3 Sunday night, moved to -3.5 Monday morning and -4 Tuesday afternoon. In the past hour, K.C. briefly got to -4.5, but quickly dipped back to -4.

On Wednesday, WynnBet senior trader Motoi Pearson noted early sharp play on Kansas City at -3 and -3.5. The public is surely heavily invested in the Chiefs' home opener, too. Point-spread ticket count is 2/1 and point-spread money beyond 2.5/1 on Kansas City.

Bettors are also firing on Chiefs moneyline, which opened -170, peaked at -220 and is now -215. Moneyline tickets and cash are running 3/1 and 5/1, respectively, on Kansas City.

"We are going to need the Chargers in every which way," WynnBet trader Andy Morrissey said. "It's a very popular game, with slight liability to the Over. A Chargers [outright] win would be ideal for us."

The total opened at 54.5, inched down to 54 Wednesday afternoon, then returned to 54.5 in the past hour. Ticket count is approaching 2/1 and money is approaching 3/1 on the Over.

UPDATE 2:30 P.M. ET WEDNESDAY: On Sunday evening, DraftKings pegged Kansas City a 3-point favorite in the NFL Week 2 odds market. By early Monday morning, the Chiefs rose to -3.5, then Tuesday afternoon moved to -4 and -4.5.

Late this morning, K.C. nudged back to -4. Then interestingly, the Chiefs again advanced to -4.5 (even) and stayed there, even after news broke in just the past 30 minutes that place-kicker Harrison Butker (ankle) is out. ESPN's Adam Schefter reported that former Jets kicker Matt Amendola is expected to kick for Kansas City on Thursday night.

Point-spread ticket count and money are running 3/1-plus for the Chiefs at DraftKings.

The total toggled between 54 and 54.5 a couple of times early in the week, then settled at 54.5 Monday afternoon. It's currently 54.5 (Under -120), with ticket count almost 3/1 on the Over, but money 2/1-plus on the Under.

UPDATE MIDNIGHT ET SUNDAY: Kansas City (1-0 SU and ATS) got its offensive machine in gear right out of the gate. Patrick Mahomes threw for 390 yards and five TDs, with no INTs, as the Chiefs steamrolled Arizona 44-21 laying 6 points on the road.

Los Angeles (1-0 SU and ATS) had a more stern challenge at home against the Las Vegas Raiders. But the Chargers nabbed the win and cover, 24-19 as 3.5-point favorites.

Early bettors of NFL Week 2 odds were intrigued by K.C.

"We opened the Chiefs -3 and moved quickly to -3 (-120), and finally -3.5, after a respected player didn’t balk at laying the 20 cents," Murray said Sunday night. "Kansas City was very impressive today. We’ll see how much of that is the fault of the Cardinals. This is a pretty solid matchup for a Thursday game. There should be really big handle."

The Chiefs are now at -3.5 (even). The total held stable at 54 Sunday night.

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