Patriots vs. Bills Predictions: Patriots Bounce Back
Dylan Wilkerson Sports Betting Expert
The New England Patriots will take on the Buffalo Bills in this week's NFL action. Kickoff is set for 1:00 PM EST at Highmark Stadium in Orchard Park, NY. The game will be broadcast live on CBS. Here's everything you need to know about Patriots vs. Bills odds, the latest college football spreads, college football over/unders and more.
NE @ BUF Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open |  › |  › |  › |  › |  › |  › |  › |  › |  | ||
 253 Patriots | +3 -110 | +7 -115 | +6.5 -105 | +7 -115 | +7 -115 | +6.5 -100 | +7 -110 | +7 -115 | +6.5 -104 | +7 -115 | |
 254 Bills | -3 -110 | -7 -105 | -6.5 -115 | -7 -105 | -7 -105 | -6.5 -122 | -7 -110 | -7 -105 | -6.5 -115 | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o48.5 -110 | o48.5 -108 | o48.5 -115 | o48.5 -110 | o48.5 -114 | o48.5 -110 | o48.5 -110 | o48 -113 | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u48.5 -110 | u48.5 -110 | u48.5 -105 | u48.5 -110 | u48.5 -106 | u48.5 -110 | u48.5 -110 | u48 -108 | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +255 | +270 | +245 | +260 | +275 | +250 | +250 | +250 | +245 | |
| 254 Bills | -162 | -315 | -325 | -305 | -325 | -340 | -325 | -320 | -315 | -305 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +3 -110 | +3.5 even | +3.5 even | +3.5 even | +3.5 even | +4.5 -120 | +3.5 -105 | +3.5 even | +3.5 even | +7 -115 | |
| 254 Bills | -3 -110 | -3.5 -120 | -3.5 -120 | -3.5 -120 | -3.5 -121 | -4.5 -100 | -3.5 -125 | -3.5 -120 | -3.5 -124 | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o24.5 even | o24.5 even | o24.5 +105 | o24 -113 | o24.5 -100 | o24.5 -105 | o24.5 -110 | o24.5 -107 | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u24.5 -120 | u24.5 -120 | u24.5 -125 | u24 -107 | u24.5 -120 | u24.5 -125 | u24.5 -120 | u24.5 -115 | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +185 | +190 | +180 | +188 | +210 | N/A | +185 | +195 | +245 | |
| 254 Bills | -162 | -225 | -235 | -218 | -235 | -270 | N/A | -225 | -245 | -305 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +3 -110 | +0.5 even | +1.5 -112 | +2.5 -110 | N/A | +1.5 -116 | +1.5 -115 | +2.5 -105 | +1.5 -122 | +7 -115 | |
| 254 Bills | -3 -110 | -0.5 -120 | -1.5 -112 | -2.5 -110 | N/A | -1.5 -106 | -1.5 -115 | -2.5 -115 | -1.5 even | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o9.5 -120 | o9.5 -125 | o9.5 -120 | N/A | o9.5 -124 | o9.5 -125 | o9.5 -125 | o9.5 -132 | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u9.5 even | u9.5 -105 | u9.5 even | N/A | u9.5 +102 | u9.5 -105 | u9.5 -105 | u9.5 +105 | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +165 | +160 | +180 | N/A | +158 | N/A | +160 | +145 | +245 | |
| 254 Bills | -162 | -200 | -210 | -218 | N/A | -196 | N/A | -215 | -180 | -305 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +3 -110 | +3.5 -120 | N/A | +3.5 -110 | N/A | +3.5 -115 | +3.5 -120 | N/A | +2.5 +102 | +7 -115 | |
| 254 Bills | -3 -110 | -3.5 even | N/A | -3.5 -120 | N/A | -3.5 -105 | -3.5 -110 | N/A | -2.5 -127 | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o23.5 -115 | N/A | o23.5 -118 | N/A | o23.5 -115 | o23.5 -120 | N/A | o23.5 -105 | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u23.5 -105 | N/A | u23.5 -102 | N/A | u23.5 -105 | u23.5 -110 | N/A | u23.5 -120 | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +165 | N/A | +170 | N/A | +174 | N/A | N/A | +155 | +245 | |
| 254 Bills | -162 | -200 | N/A | -220 | N/A | -205 | N/A | N/A | -195 | -305 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +3 -110 | N/A | N/A | +2.5 -115 | N/A | +3.5 -130 | +2.5 even | N/A | N/A | +7 -115 | |
| 254 Bills | -3 -110 | N/A | N/A | -2.5 -115 | N/A | -3.5 +106 | -2.5 -130 | N/A | N/A | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o14.5 -110 | N/A | o14.5 -110 | N/A | o14.5 -108 | o14.5 -115 | N/A | N/A | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u14.5 -120 | N/A | u14.5 -120 | N/A | u14.5 -112 | u14.5 -115 | N/A | N/A | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +150 | N/A | +135 | N/A | +176 | N/A | N/A | N/A | +245 | |
| 254 Bills | -162 | -190 | N/A | -175 | N/A | -220 | N/A | N/A | N/A | -305 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +3 -110 | N/A | N/A | +0.5 -115 | N/A | +1.5 -122 | +0.5 -115 | N/A | N/A | +7 -115 | |
| 254 Bills | -3 -110 | N/A | N/A | -0.5 -115 | N/A | -1.5 -100 | -0.5 -115 | N/A | N/A | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o9.5 -135 | N/A | o9.5 -135 | N/A | o9.5 -130 | o9.5 -135 | N/A | N/A | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u9.5 +105 | N/A | u9.5 +105 | N/A | u9.5 +108 | u9.5 +105 | N/A | N/A | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +140 | N/A | +145 | N/A | +148 | N/A | N/A | N/A | +245 | |
| 254 Bills | -162 | -180 | N/A | -188 | N/A | -184 | N/A | N/A | N/A | -305 | |
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +3 -110 | +0.5 even | N/A | +1.5 -110 | N/A | +1.5 -118 | +1.5 -120 | N/A | N/A | +7 -115 | |
| 254 Bills | -3 -110 | -0.5 -130 | N/A | -1.5 -120 | N/A | -1.5 -104 | -1.5 -110 | N/A | N/A | -7 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | o49.5 -110 | o13.5 -120 | N/A | o13.5 -130 | N/A | o13.5 -116 | o13.5 -120 | N/A | N/A | o48.5 -115 | |
| 254 Bills | u49.5 -110 | u13.5 -110 | N/A | u13.5 even | N/A | u13.5 -106 | u13.5 -110 | N/A | N/A | u48.5 -105 | |
| Open | › | › | › | › | › | › | › | › | | ||
| 253 Patriots | +136 | +135 | N/A | +145 | N/A | +138 | N/A | N/A | N/A | +245 | |
| 254 Bills | -162 | -170 | N/A | -188 | N/A | -170 | N/A | N/A | N/A | -305 | |
The Buffalo Bills opened as a -7 point favorite to New England. The total is set at over/under 48.5 total points scored by both teams combined.
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Updated on 10/1/26
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Patriots vs. Bills Prediction
Action Network's Nick Giffen releases a weekly luck rankings, and it is one of the best metrics to use when deciding on which NFL teams to bet. In those rankings, the Bills come in as the 2nd luckiest team and the Patriots are 23rd. This tells me that there could be regression inbound for the Buffalo Bills and the Patriots are due to take a step up.
Surprisingly enough, the Patriots defense has been strong. Via PFF's power rankings, the Patriots come in as the 4th strongest defense. I think New England keeps this close.
Updated on 10/1/26
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Patriots vs. Bills Prediction: New England Patriots +7 (-110) + ML (+260)
(Pick from Dylan Wilkerson)
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