Last Updated Nov 05, 2021, 11:00 PM

Buffalo Bills vs. Jacksonville Jaguars Predictions, Odds, Picks

Nov. 7, 2021
Jonathan Willis
VI Betting Expert

The struggling Jacksonville Jaguars host the dominant Buffalo Bills in a 'David vs. Goliath' battle on Sunday. Action is set to begin at 1:00 p.m. ET and will air on CBS from TIAA Bank Field in Jacksonville, Florida.

Score Prediction

Bills 38, Jaguars, 17

Best Bets

Bills -14


Buffalo Bills vs. Jacksonville Jaguars Predictions

The Buffalo Bills are now the favorites to win Super Bowl LVI. Buffalo has yet to beat a team with a winning record and lost to the two teams with winning records it played this season, but the Bills have pounded all the outmatched teams they have faced to this point. All five of their wins have been by at least 15 points, so they should cover the number against the Jacksonville Jaguars on Sunday.

Josh Allen has become the front runner to win the 2021 NFL MVP. Allen has surpassed Tom Brady and Kyler Murray, and he should light up the stat sheet against the Jacksonville Jaguars. Jacksonville is coming off a bad loss to Seattle after its bye week, and this might be the worst team in the NFL for the second straight season.

Buffalo Bills vs. Jacksonville Jaguars Betting Odds

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Buffalo Bills vs. Jacksonville Jaguars Betting Resources

  • Matchup: AFC East vs. AFC South
  • Date: Sunday, November 7, 2021
  • Venue: TIAA Bank Field
  • Location: Jacksonville, Florida
  • TV-Time: CBS - 1:00 p.m. ET

Buffalo Bills Betting Analysis

Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 5-2
  • ATS: 4-2-1
  • O/U: 3-4
  • ATS - Home: 2-1-1
  • ATS - Away: 2-1

Allen has been great over the last two years. Allen has thrown just three interceptions in 272 passes, avoiding the mistakes that plagued him at Wyoming and early on in Buffalo. He is also one of the best running quarterbacks in the NFL, averaging 5.2 YPC as the Bills’ second leading rusher.

Buffalo won’t have top tight end Dawson Knox available this week because of injury, and Cole Beasley is questionable. That will make Allen very reliant on Stefon Diggs and Emmanuel Sanders, but both receivers could end up making the Pro Bowl. Zack Moss has been a solid receiver out of the backfield too.

The Bills have the best defense in the NFL. Buffalo ranks first in scoring defense (15.6 PPG), total defense (269 YPG), and yards per play (4.6 YPP) This secondary has been exceptional as Tre’Davious White should be an All-Pro once again, and Tremaine Edmunds is making things happen in the middle of the defense.

Jacksonville Jaguars Betting Analysis

Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 1-6
  • ATS: 2-5
  • O/U: 2-5
  • ATS - Home: 1-3
  • ATS - Away: 1-2

Trevor Lawrence appeared to be turning the corner for the Jaguars. He wasn’t bad in his three games going into the bye week, but he had a major setback against Seattle last Sunday. Lawrence averaged just 4.4 YPA on a whopping 54 passes, failing to complete a pass longer than 17 yards in a 31-7 loss to the Seahawks.

The Jaguars have two decent receivers in Marvin Jones Jr. and Laviska Shenault Jr. - Lawrence’s favorite targets after D.J. Chark was lost for the season with an injury. Shenault has yet to catch a touchdown pass though despite catching 86 passes since he came into the league last year.

James Robinson might be the most underrated running back in the NFL. He ran for over 1,000 yards in 14 games as a rookie last year, and he is averaging 5.5 YPC this season. Unfortunately, he is dealing with a heel injury and is listed as questionable.

Jacksonville has one of the worst defenses in the NFL. The Jaguars are allowing 8.6 YPA, and they rank in the bottom five in scoring defense. Their total defense numbers have improved as opponents are just running the ball into the line in garbage time, but Buffalo can make this front seven pay with its run game.

Inside the Stats - Buffalo Bills

  • Record: 5-2
  • Division Standing: 1st - AFC East
  • Points Scored: 229
  • Points Allowed: 109
  • PS/G: 32.7 (1st)
  • PA/G: 15.6 (1st)

Inside the Stats - Jacksonville Jaguars

  • Record: 1-6
  • Division Standing: 3rd - AFC South
  • Points Scored: 123
  • Points Allowed: 203
  • PS/G: 17.6 (28th)
  • PA/G: 29 (28th)

Key Players to Watch

  • BUF: Josh Allen - QB (178/272, 1,972 yards, 17 TD, 3 INT)
  • BUF: Stefon Diggs - WR (42 catches, 503 yards, 3 TD)
  • JAC: Trevor Lawrence - QB (161/270, 1,703 yards, 8 TD, 9 INT)
  • JAC: Marvin Jones, Jr. - WR (33 catches, 378 yards, 3 TD)

Buffalo Bills vs. Jacksonville Jaguars Betting Conclusion

Style points aren’t a thing in the NFL, but don’t tell that to Buffalo. The Bills have repeatedly smashed bad teams this season, and the Jaguars are definitely a bad team. Allen will air it out and take Buffalo to an early lead, and the Bills will only turn it on from there.

Buffalo Bills vs. Jacksonville Jaguars Betting Trends

  • Jacksonville has lost 21 of its last 22 games.
  • Jacksonville has gone UNDER the point total in five of its last six games.
  • The point total has gone OVER in four of the last five meetings.
  • Jacksonville has failed to cov er the spread in five straight home games.

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