Last Updated Nov 12, 2021, 10:00 PM

Jacksonville Jaguars vs. Indianapolis Colts Predictions, Odds, Picks

Nov. 14, 2021
Jonathan Willis
VI Betting Expert

An AFC South battle on Sunday sees the Indianapolis Colts host the Jacksonville Jaguars. Kick off is scheduled for 1:00 p.m. ET and will air on CBS from Lucas Oil Stadium in Indianapolis, Indiana.

Score Prediction

Jaguars 34, Colts 17

Best Bets

Colts -10


Jacksonville Jaguars vs. Indianapolis Colts Predictions

A win on Sunday would bring the Indianapolis Colts back to .500. Indianapolis hasn’t been .500 since the start of the season, but the Colts have improved as the season has progressed. Carson Wentz isn’t a world-beater under center, yet he is an improvement, and the offensive line is playing much better too. That should lead the Colts to a convincing win over the Jacksonville Jaguars in Week 10.

Favorites have taken a beating over the last week. Buffalo, Dallas, Baltimore, and others all stumbled as sizable favorites by the NFL betting odds with Jacksonville delivering the biggest upset of them all. The Jaguars took advantage of turnovers to knock off the Bills last Sunday, but they won’t have that type of luck this time.

Jacksonville Jaguars vs. Indianapolis Colts Betting Odds

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Jacksonville Jaguars vs. Indianapolis Colts Betting Resources

  • Matchup: AFC South
  • Date: Sunday, November 14, 2021
  • Venue: Lucas Oil Stadium
  • Location: Indianapolis, Indiana
  • TV-Time: CBS - 1:00 p.m. ET

Jackosnville Jaguars Betting Analysis

Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 2-6
  • ATS: 3-5
  • O/U: 2-6
  • ATS - Home: 1-3
  • ATS - Away: 1-2

Trevor Lawrence has not had the best rookie season. Lawrence came into the NFL with a ton of fanfare, but he has thrown more interceptions than touchdowns and is completing less than 60% of his passes. The No. 1 overall pick has shown flashes of brilliance, yet it’s going to take time for him to play at a high level.

The Jaguars are hoping that James Robinson can start at running back this week. He missed last week’s win over Buffalo with a heel injury, and he is listed as questionable. Robinson is averaging 5.5 YPC and Carlos Hyde isn’t nearly as productive.

Laviska Shenault Jr. is still waiting to make his first touchdown reception. Shenault has 90 receptions since joining the league last season, but he has largely been used on underneath routes and isn’t a red zone threat.

There isn’t a lot of talent on this defense. Jacksonville has not drafted well on this side of the ball since Jalen Ramsey was taken in the first round. The pass defense is one of the worst in the NFL with opponents averaging 7.9 YPA and 272.0 YPG, and the front seven isn’t as solid as you might think given that teams are running into the line to burn clock in garbage time.

Indianapolis Colts Betting Analysis

Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 4-5
  • ATS: 4-5
  • O/U: 6-3
  • ATS - Home: 3-2
  • ATS - Away: 3-1

Wentz still makes some poor throws at times, but he has largely played mistake free football with Indianapolis after a dismal 2020 campaign in Philadelphia. He is averaging 7.3 YPA and has thrown just three interceptions in nine games.

The Colts have an elite receiver once again. Michael Pittman Jr. has filled the void that the oft-injured T.Y. Hilton has created, and he has double the receiving yards as the next closest player on the Colts. Tight end Mo Alie-Cox is a red zone threat too with 14 catches and four touchdown receptions.

This ground game might be the best in the NFL with the offensive line healthy once more. Quenton Nelson and Ryan Kelly are two of the top interior linemen in the league, and Jonathan Taylor is the second leading rusher in the league with 821 rushing yards. He is averaging 5.9 YPC.

Indianapolis has a solid run defense. The front seven is surrendering 4.0 YPC and just over 100 YPG on the ground. DeForest Buckner is back to being a force in the middle of the defensive line, but he is questionable to play. The secondary is a big issue as Xavier Rhodes was ruled out and the safeties aren’t great.

Inside the Stats - Jacksonville Jaguars

  • Record: 2-6
  • Division Standing: 3rd - AFC South
  • Points Scored: 132
  • Points Allowed: 209
  • PS/G: 16.5 (31st)
  • PA/G: 26.1 (27th)

Inside the Stats - Indianapolis Colts

  • Record: 4-5
  • Division Standing: 2nd - AFC South
  • Points Scored: 245
  • Points Allowed: 213
  • PS/G: 27.2 (7th)
  • PA/G: 23.7 (16th)

Key Players to Watch

  • JAC: Trevor Lawrence - QB (176/296, 1,821 yards, 8 TD, 9 INT)
  • JAC: Marvin Jones - WR (36 catches, 399 yards, 3 TD)
  • IND: Carson Wentz - QB (190/300, 2,198 yards, 17 TD, 3 INT)
  • IND: Jonathan Taylor - RB (140 carries, 821 yards, 8 TD)

Jacksonville Jaguars vs. Indianapolis Colts Betting Conclusion

The Colts will move to 5-5 with a big win over the Jaguars this weekend. Indianapolis will be able to make Jacksonville one-dimensional on offense, while the Colts can run on this front.

Jacksonville Jaguars vs. Indianapolis Colts Betting Trends

  • Jacksonville has lost 12 straight road games.
  • Indianapolis has gone OVER the point total in five of its last six games.
  • Jacksonville has covered the spread in 10 of its last 12 games when facing Indianapolis.
  • The point total has gone OVER in three of the last four meetings.

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