Last Updated May 25, 2022, 8:58 PM

St. Louis Blues vs. Colorado Avalanche Picks, Predictions, Odds

The St. Louis Blues and the Colorado Avalanche meet at Ball Arena in Denver on Wednesday night for Game 5 of the Western Conference Semifinals, a best-of-seven series. The Avalanche lead the series 3-1. Puck drop is scheduled for 8 p.m. ET, and the game can be viewed on TNT.

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Score Prediction

Avalanche 5, Blues 2

Best Bet

Avalanche -1.5 (+110)
Over 6.5 (-108)

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The Blues got off to a great start in this series, pushing the Avalanche to the limit in Game 1 before falling in overtime. Jordan Binnington and the Blues rebounded for the stunning road victory in Game 2, gaining the road split, while seizing home-ice advantage from the No. 1 seed in the Western Conference. The Blues were living large, thinking big and hoping to stun the world after a pair of games in the Gateway City.

In Game 3, the Blues lost Binnington to an injury on a collision with Nazem Kadri which is seen differently depending on which sweater you're wearing and which team you're cheering for. Kadri was accosted online, with awful racist comments and even death threats, prompting the team to beef up security. Games should never result in such behavior, especially given the ugly real-life sadness we saw on Tuesday in Texas. Anyway, Kadri responded the best way he could in Game 4, notching his first-ever playoff hat trick.

Colorado is now 4-0 in the playoffs on the road this season, and the Carolina Hurricanes might want to download some film of what they're doing, as the Avalanche is looking like a championship-caliber team.

St. Louis is just trying to extend its season one game at a time. Torey Krug has been dealing with a lower-body injury since early in the Minnesota series, but he has been skating with the team. If he pushed to return, his presence along with the blueline would be a giant help for the Blues, but there is no official word if that will happen.


Blues +210
Avalanche -233
Blues +1.5 (-115)
Avalanche -1.5 (+110)
Over 6.5 (-108)
Under 6.5 (-105)

More Odds Futures Odds


  • Date: Wednesday, May 25, 2022
  • Matchup: Central vs. Central
  • Venue: Ball Arena
  • Location: Denver, Colo.
  • TV-Time: TNT, 8:00 p.m. ET


Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 54-26-12
  • ATS: 53-39
  • O/U: 48-39-5

The Blues were dismantled in both games on home ice, losing by a combined score of 11-5. Losing Binner certainly didn't help, and while Ville Husso hasn't been terrible, he hasn't been great, and that's what St. Louis needs as a heavy underdog.

David Perron has been tremendous in these playoffs, posting nine goals and 13 points in 10 postseason outings, including four goals in the past three games in this series.

The Blues have won 19 of the past 28 games overall, but they're obviously 1-3 in this series, and that's all that matters. They're also 10-3 in the past 13 road games, winning Game 2 in Denver. They need to win two more on the road in this series, and a home outing in Game 6, to stun the world. It's not looking good.

For totals, the OVER is 24-11-1 in the past 36 games overall for the Blues, while going 13-4-1 in the past 18 games on the road. However, they're just 2-7 in the past nine trips to Denver, and 2-9 in the past 11 tries overall against the Avs.


Straight Up - SU, Against the Spread - ATS, Over-Under (O/U)

  • SU: 63-20-7
  • ATS: 44-46
  • O/U: 47-38-5

The Avalanche can push the Blues to the handshake line, advancing to the Western Conference Finals for the first time since 2002 when they lost in seven games to the Detroit Red Wings. Prior to that, the Avs won the Stanley Cup in seven games against the New Jersey Devils in 2001. That seems like a lifetime ago, but these Avs are for real, and have the offense, defense and goaltending to keep it cooking.

The Avalanche have won 51 of the past 69 games overall, and they're an impressive 55-12 in the past 67 in the Mile High City. The fact the Blues stole Game 2, and nearly took Game 1, should give Blues fans hope. But the truth of the matter is that the Avalanche just do not lose on home ice, and St. Louis might have punched themselves out in the first two games.

On totals, the OVER has connected in seven of the past 10 for the Avalanche when favored, while going 8-3 in the past 11 in the Conference Semifinals Round. The OVER is also 8-2 in the past 10 meetings between these teams, including the past two games. The UNDER cashed in Games 1 and 2 in Denver.

The Avs look to top the Blues in Game 5 in an elimination game. (Getty Images)


The Blues are fighting to keep their season alive, but the Avalanche are tough. They're not having it, and flexed its championship muscle with a pair of road victory in The Lou. The Blues had their chance, but were unable to capitalize on their Game 2 road win, suffered the bad luck of the Binnington injury, and then just haven't had any answers for Darcy Kuemper, while the Avalanche offense has feasted on Husso in the past two games.

This series is going to be over in Game 5, and it will be OVER on the scoreboard, too, and the Avalanche on the puck line with the OVER is worth a parlay play. Look for a fairly close game until some empty-net goals help inch the total across the board late, with the Blues ending up in the handshake line after an impressive season.


  • Blues are 19-9 in the past 28 games overall.
  • Blues are 10-3 in the past 13 road games.
  • Blues are 4-10 in the past 14 playoff games as a 'dog.
  • Avalanche are 51-18 in the past 59 games overall.
  • Avalanche are 55-12 in the past 67 home games.
  • Avalanche are 24-9 in the past 33 playoff games as a favorite.
  • Avalanche are 11-21 in the past 32 Conference Semifinals games.
  • OVER is 24-11-1 in the past 36 games for the Blues.
  • OVER is 13-4-1 in the past 18 road games for the Blues.
  • OVER is 7-3 in the past 10 as a favorite for the Avalanche.
  • OVER is 8-3 in the past 11 Conference Semifinals games for the Avs.
  • Favorite is 41-16 in the past 57 meetings.
  • Blues are 2-9 in the past 11 meetings.
  • Blues are 2-7 in the past nine trips to Denver.
  • OVER is 8-2 in the past 10 meetings.
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