Last Updated Sep 19, 2022, 9:23 AM

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The Seattle Seahawks will face the host San Francisco 49ers on Sunday in a Week 2 NFC West matchup. Kickoff is slated for 4:05 p.m. ET from Levi’s Stadium. Coverage will be televised on FOX. 

The Seahawks defeated their former star quarterback Russell Wilson and the Denver Broncos 17-16 on Monday Night Football in Week 1. With the Broncos down by 1 on fourth-and-5 in Seattle territory, Denver elected to kick a 64-yard field goal, instead of going for it. Brandon McManus missed the kick with under 20 seconds left. Seahawks quarterback Geno Smith tossed both of his two touchdowns in the first half to tight ends, one to Colby Parkinson and the other to Will Dissly

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The 49ers fell 19-10 to the host Chicago Bears in Week 1. The 49ers went ahead 10-0 before the Bears scored the final 19 points to earn the victory. Deebo Samuel’s six-yard score was the lone touchdown for the 49ers. In his sophomore debut, 49ers quarterback Trey Lance went 13-for-28 with 164 yards and an interception. The 49ers gave up a 51-yard touchdown from Justin Fields to Dante Pettis in the third quarter. The 49ers held the Bears to 99 rushing yards on 37 carries. 

The Seahawks’ offense is tied for 24th in rushing yards (76.0), while also ranking 25th in points per game (17.0), and 27th in passing yards (177.0). Smith has passed for 195 yards, two touchdowns, and no interceptions. Dissly has three receptions for 43 yards and a touchdown. Parkinson has two receptions for 43 yards and a touchdown. Wide receiver DK Metcalf has tallied seven receptions for 36 yards. Running back Rashad Penny has collected 60 yards on his 12 carries, along with one 20+ yard rush, two first downs, and a fumble. 

Defensively, the Seahawks rank seventh in points per game allowed (16.0). Linebacker Jordan Brooks leads the Seahawks with 12 tackles. Linebacker Cody Barton has collected 10 tackles, a sack, and two tackles for loss. Uchenna Nwosu has amassed seven tackles, a sack, a tackle for loss, and a forced fumble. Cornerback Mike Jackson has tallied four tackles, a tackle for loss, a pass deflection, and two fumble recoveries. 

The 49ers’ offense ranks seventh in rushing yards (176.0), tied for 27th in points per game (10.0), and 30th in passing yards (155.0). Lance is averaging 5.9 yards per completion with a quarterback rating of 50.3. Lance has been sacked twice. On the ground, Lance has rushed for 54 yards on 13 carries with six first downs. Samuel has rushed for 52 yards on eight carries with a long of 27 and three first downs. Wide receiver Jauan Jennings has caught four receptions for 62 yards and two first downs. Wide receiver Brandon Aiyuk has two catches for 40 yards, one of which is over 20+ yards. 

Defensively, the 49ers rank tied for 22nd in points per game allowed (19.0). Safety Talanoa Hufanga leads the 49ers with 11 tackles, two tackles for loss, a pass deflection, and an interception. Linebacker Fred Warner has tallied six tackles. Defensive end Nick Bosa has five tackles and a sack. Linebacker Azeez Al-Shaair has recorded five tackles. Defensive end Samson Ebukam has a 10-yard sack. 

As of Sept. 14, among the players on the injury report for the Seahawks include cornerback Artie Burns (questionable), safety Jamal Adams (out), LS Tyler Ott (IR), safety Quandre Diggs (questionable), and defensive end Shelby Harris (questionable). 

Prior to Sept. 15, some of the players on the injury report for the 49ers are: offensive tackle Daniel Brunskill (questionable), running back Elijah Mitchell (IR), tight end George Kittle (questionable), linebacker Dre Greenlaw (questionable), and defensive end Jordan Willis (IR).

In the 49ers and Seahawks game, the 49ers are favored by 8.5 points. For the money line, it’s Seahawks +310 and 49ers -390. The over/under is set for 41.5 points. 

With these teams very familiar with one another, expect a defensive battle and the under to occur. 

The Seahawks lead the all-time series 30-17 against the 49ers, including a victory in the 2013 NFC Championship Game. 

The Seahawks will cover the spread but the 49ers will earn the division victory.

Written by Rolando Rosa, our US sports betting industry expert. 

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