Oklahoma vs. Alabama: Prediction, Odds, Best Bet

Oklahoma vs. Alabama: Prediction, Odds, Best Bet

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OU @ BAMA Odds

The Oklahoma Sooners will take on the Alabama Crimson Tide in this week's college football action. Kickoff is set for 3:30 p.m. EST at Bryant-Denny Stadium in Tuscaloosa, Ala. The game will be broadcast live on ABC. Here's everything you need to know about Oklahoma vs. Alabama odds, the latest college football spreads, college football over/unders and more.

This game is featured on my college football week 12 best bets piece!

The Alabama Crimson Tide opened as a -6.5 point favorite over Oklahoma. The total is set at over/under 45.5 total points scored by both teams combined.

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Updated on 12/26/25

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Oklahoma vs. Alabama Best Bet

If you love defense, then boy is this the matchup for you. Oklahoma has the top-rated defense in terms of defensive success rate, ranking 1st against the rush and 7th against the pass. This is thanks to their extremely strong defensive line and their ability to rush the passer. Quarterback Ty Simpson has been great for Alabama. However, I think this Oklahoma defense will be too much for the Alabama offensive line to handle. I think Alabama will win this game, but Oklahoma will keep it within reach the entire way.

Oklahoma vs. Alabama Best Bet: Oklahoma Sooners +6.5 (-110)

(Pick from Dylan Wilkerson)

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What Time is the Oklahoma vs. Alabama Game?

The Sooners will take on the Crimson Tide at 3:30 PM ET on Saturday, November 15th.

Where is the Oklahoma vs. Alabama Game Being Played?

This game is going to be played at Bryant-Denny Stadium in Tuscaloosa, Ala.

How Can I Watch The Oklahoma vs. Alabama Game?

You can watch Oklahoma vs. Alabama on ABC.

Can Oklahoma Beat The Alabama Crimson Tide?

Absolutely! Oklahoma is a slight underdog in this game. Anything can happen in college football!