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Featured Last Updated Aug 28 2025, 3:09 PM

Clemson vs. LSU, Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
9 minute read
Clemson vs. LSU, Prediction, Odds, Best Bet

Image Credit: Aaron E. Martinez/USA Today Network via Imagn Images

LSU @ CLEM Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
LSU Tigers 219 LSU
+2.5 -110 +2.5 even + +2.5 even + +2.5 -102 + +2.5 even + +2.5 -105 + +2.5 -106 + +2.5 -110 +2.5 -110 + +3.5 -110  
Clemson Tigers 220 Clemson
-2.5 -110 -2.5 -120 + -2.5 -120 + -2.5 -118 + -2.5 -120 + -2.5 -125 + -2.5 -114 + -2.5 -113 -2.5 -113 + -3.5 -110  
LSU Tigers 219 LSU
o56.5 -110 o28.5 -105 + N/A o28.5 -102 + o28.5 -105 + N/A o29.5 -105 + o27.5 -113 o27.5 -113 + o57.5 -110  
Clemson Tigers 220 Clemson
u56.5 -110 u28.5 -115 + N/A u28.5 -118 + u28.5 -115 + N/A u29.5 -115 + u27.5 -115 u27.5 -115 + u57.5 -110  
LSU Tigers 219 LSU
+114 +130 + +135 + +130 + +130 + +125 + +128 + +120 +120 + +150  
Clemson Tigers 220 Clemson
-135 -155 + -160 + -155 + -155 + -160 + -158 + -157 -157 + -180  
LSU Tigers 219 LSU
+2.5 -110 +0.5 -120 + +0.5 -120 + +0.5 -112 + +0.5 -125 + +0.5 -120 + +1.5 -145 + +1.5 -137 +1.5 -137 + +3.5 -110  
Clemson Tigers 220 Clemson
-2.5 -110 -0.5 -110 + -0.5 -110 + -0.5 -108 + -0.5 -105 + -0.5 -110 + -1.5 +116 + -1.5 +106 -1.5 +106 + -3.5 -110  
LSU Tigers 219 LSU
o56.5 -110 o13 -110 + N/A o13.5 -102 + o13 -115 + o13.5 -105 + o13.5 -110 + o12.5 -125 o12.5 -125 + o57.5 -110  
Clemson Tigers 220 Clemson
u56.5 -110 u13 -120 + N/A u13.5 -118 + u13 -115 + u13.5 -125 + u13.5 -114 + u12.5 -104 u12.5 -104 + u57.5 -110  
LSU Tigers 219 LSU
+114 +125 + +125 + +124 + +130 + +125 + +114 + +117 +117 + +150  
Clemson Tigers 220 Clemson
-135 -155 + -165 + -148 + -160 + -160 + -146 + -152 -152 + -180  
LSU Tigers 219 LSU
+2.5 -110 N/A N/A +1.5 -112 + +0.5 -115 + N/A N/A N/A N/A +3.5 -110  
Clemson Tigers 220 Clemson
-2.5 -110 N/A N/A -1.5 -108 + -0.5 -105 + N/A N/A N/A N/A -3.5 -110  
LSU Tigers 219 LSU
o56.5 -110 N/A N/A o28.5 even + o27.5 -120 + N/A N/A N/A N/A o57.5 -110  
Clemson Tigers 220 Clemson
u56.5 -110 N/A N/A u28.5 -120 + u27.5 even + N/A N/A N/A N/A u57.5 -110  
LSU Tigers 219 LSU
+114 N/A N/A +120 + N/A N/A N/A N/A N/A +150  
Clemson Tigers 220 Clemson
-135 N/A N/A -142 + N/A N/A N/A N/A N/A -180  
LSU Tigers 219 LSU
+2.5 -110 N/A N/A +0.5 -125 + N/A +0.5 -120 + +1.5 -128 + N/A N/A +3.5 -110  
Clemson Tigers 220 Clemson
-2.5 -110 N/A N/A -0.5 -105 + N/A -0.5 -110 + -1.5 -104 + N/A N/A -3.5 -110  
LSU Tigers 219 LSU
o56.5 -110 o16.5 -115 + N/A o14.5 -115 + N/A o15.5 -115 + o16.5 -132 + N/A N/A o57.5 -110  
Clemson Tigers 220 Clemson
u56.5 -110 u16.5 -115 + N/A u14.5 -115 + N/A u15.5 -115 + u16.5 +106 + N/A N/A u57.5 -110  
LSU Tigers 219 LSU
+114 +120 + N/A +105 + N/A N/A +122 + N/A N/A +150  
Clemson Tigers 220 Clemson
-135 -150 + N/A -135 + N/A N/A -156 + N/A N/A -180  
LSU Tigers 219 LSU
+2.5 -110 N/A N/A +0.5 -135 + N/A +0.5 -130 + +1.5 -144 + N/A N/A +3.5 -110  
Clemson Tigers 220 Clemson
-2.5 -110 N/A N/A -0.5 +105 + N/A -0.5 even + -1.5 +108 + N/A N/A -3.5 -110  
LSU Tigers 219 LSU
o56.5 -110 o13.5 -125 + N/A o13.5 -115 + N/A o13.5 -120 + o13.5 -114 + N/A N/A o57.5 -110  
Clemson Tigers 220 Clemson
u56.5 -110 u13.5 -105 + N/A u13.5 -115 + N/A u13.5 -110 + u13.5 -110 + N/A N/A u57.5 -110  
LSU Tigers 219 LSU
+114 +110 + N/A +114 + N/A N/A +120 + N/A N/A +150  
Clemson Tigers 220 Clemson
-135 -140 + N/A -145 + N/A N/A -154 + N/A N/A -180  
LSU Tigers 219 LSU
+2.5 -110 +0.5 -145 + N/A +0.5 -135 + N/A +0.5 -130 + +1.5 -152 + N/A N/A +3.5 -110  
Clemson Tigers 220 Clemson
-2.5 -110 -0.5 +115 + N/A -0.5 +105 + N/A -0.5 even + -1.5 +116 + N/A N/A -3.5 -110  
LSU Tigers 219 LSU
o56.5 -110 o16 -115 + N/A o14.5 -120 + N/A o15.5 -110 + o13.5 -148 + N/A N/A o57.5 -110  
Clemson Tigers 220 Clemson
u56.5 -110 u16 -115 + N/A u14.5 -110 + N/A u15.5 -120 + u13.5 +118 + N/A N/A u57.5 -110  
LSU Tigers 219 LSU
+114 +105 + N/A even + N/A N/A +112 + N/A N/A +150  
Clemson Tigers 220 Clemson
-135 -135 + N/A -130 + N/A N/A -142 + N/A N/A -180  

The LSU Tigers will take on the Clemson Tigers in this week's NCAAF action. Kickoff is set for 7:30 p.m. EDT at Memorial Stadium in Clemson, S.C. The game will be broadcast live on ABC. Here's everything you need to know about LSU vs. Clemson odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Clemson Tigers opened as a -4 point favorite over the LSU Tigers. The total is set at over/under 57.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Clemson Tigers vs. LSU Tigers Best Bet

LSU will look to upend an ugly five-game losing streak of season openers. Last season, LSU lost in disappointing fashion to a marginal USC team - they'll take on a much tougher opponent in Clemson, who has legitimate national title aspirations.

Since losing the national title game in 2020 to LSU, Clemson's program has slightly fallen off from year-over-year title contender to a good-but-not-great ACC contender. However, the Tigers of Clemson were able to gather plenty of momentum down the stretch last season, winning the ACC title over SMU, and pushing Texas in the first round of the College Football Playoff.

Clemson will rely on quarterback Cade Klubnik, who is one of the early favorites to hoist the Heisman. On the other side of ball, Clemson should be terrorizing for opposing offenses, specifically the defensive line led by TJ Parker.

Parker is a projected top pick in the 2026 NFL Draft and is one of college football's best pass rushers. He'll be accompanied by Peter Woods, who is the anchor to this defense. On the back end, they'll lean on Avieon Terrell to limit this LSU passing attack, who had 13 PBU's a season ago.

Despite their poor track record, head coach Brian Kelly will have LSU ready to go in this one in what is a pivotal year in Baton Rouge. This is arguably his most talented roster since he has been there, and they have the talent to hang around with this Clemson squad.

However, the LSU offensive line has a potential nightmare matchup on their hands against this Clemson front. Garrett Nussmeier had a prolific season a year ago in part because he was able to stay upright all year long. As a pocket passer, he's bound to have some early season hurdles breaking in four new starters on the offensive line. Clemson's DL is as brutal a matchup as it gets for this new-look LSU OL to open the season with - I expect LSU to struggle to move the ball in this one.

Clemson vs. LSU Best Bet: LSU Team Total Under 27.5 (-135)

(Pick from Derek Mountain)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Clemson Tigers vs. LSU Tigers Game?

The Clemson Tigers will take on the LSU Tigers at 7:30 ET on Saturday, August 30th.

Where is the Clemson Tigers vs. LSU Tigers Game Being Played?

This game is going to be played at Memorial Stadium in Clemson, S.C

How Can I Watch Clemson vs. LSU?

You can watch Clemson vs. LSU on ABC.

Can LSU beat Clemson?

LSU can certainly beat Clemson. Although oddsmakers have Clemson as the favorite, it is slight (just 3.5 points). LSU is returning one of the nation's top signal callers in Garrett Nussmeier, and is expected to make a push for the College Football Playoff.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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