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Clemson vs. LSU Odds: Expert Prediction for Clemson vs. LSU

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Clemson vs. LSU Odds: Expert Prediction for Clemson vs. LSU

Updated on 10/19/26

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The Clemson Tigers will take on the LSU Tigers in this week's college football action. Kickoff is set for 7:30 p.m. EST at Tiger Stadium in Baton Rouge, LA. The game will be broadcast live on ABC. Here's everything you need to know about Clemson vs. LSU odds, the latest college football spreads, college football over/unders and more.

CLEM @ LSU Odds

  • Full Game
  • 1H
  • 1Q
  • 4Q
  • 2Q
  • 3Q
  • Spread
  • Total
  • Moneyline
Final
Clemson Tigers 219 Clemson
+10.5 -114 +6.5 -110 N/A +6.5 -112 +6.5 -109 +6.5 -106 +6.5 -115 +6.5 -115 +6.5 -104 +10 -102  
LSU Tigers 220 LSU
-10.5 -109 -6.5 -110 N/A -6.5 -108 -6.5 -113 -6.5 -114 -6.5 -105 -6.5 -115 -6.5 -121 -10 -118  
Final
Clemson Tigers 219 Clemson
o50.5 -113 o24.5 even o24.5 +105 o24.5 +102 o24.5 +103 o24.5 -102 o24.5 -105 o24.5 even o24.5 -117 o48.5 -108  
LSU Tigers 220 LSU
u50.5 -110 u24.5 -120 u24.5 -120 u24.5 -122 u24.5 -125 u24.5 -120 u24.5 -115 u24.5 -135 u24.5 -110 u48.5 -112  
Final
Clemson Tigers 219 Clemson
+328 +250 N/A +250 +245 +245 N/A N/A +255 +330  
LSU Tigers 220 LSU
-453 -310 N/A -310 -320 -310 N/A N/A -345 -425  
Final
Clemson Tigers 219 Clemson
+10.5 -114 +3.5 -135 N/A +3 -120 N/A +2.5 +102 +2.5 even +2.5 -105 +3.5 -122 +10 -102  
LSU Tigers 220 LSU
-10.5 -109 -3.5 +105 N/A -3 -110 N/A -2.5 -124 -2.5 -130 -2.5 -125 -3.5 -106 -10 -118  
Final
Clemson Tigers 219 Clemson
o50.5 -113 o10.5 +105 o10.5 +115 o10.5 +110 N/A o10.5 +120 o10.5 +105 o10.5 +120 o10.5 +112 o48.5 -108  
LSU Tigers 220 LSU
u50.5 -110 u10.5 -135 u10.5 -145 u10.5 -140 N/A u10.5 -146 u10.5 -135 u10.5 -165 u10.5 -139 u48.5 -112  
Final
Clemson Tigers 219 Clemson
+328 +182 N/A +170 N/A +188 N/A N/A +195 +330  
LSU Tigers 220 LSU
-453 -240 N/A -220 N/A -230 N/A N/A -265 -425  
Final
Clemson Tigers 219 Clemson
+10.5 -114 +3 -125 N/A N/A N/A +2.5 -110 +0.5 -115 N/A N/A +10 -102  
LSU Tigers 220 LSU
-10.5 -109 -3 -115 N/A N/A N/A -2.5 -112 -0.5 -115 N/A N/A -10 -118  
Final
Clemson Tigers 219 Clemson
o50.5 -113 o13.5 -120 N/A N/A N/A o13.5 -104 o13.5 -115 N/A N/A o48.5 -108  
LSU Tigers 220 LSU
u50.5 -110 u13.5 -120 N/A N/A N/A u13.5 -118 u13.5 -115 N/A N/A u48.5 -112  
Final
Clemson Tigers 219 Clemson
+328 +160 N/A N/A N/A +170 N/A N/A N/A +330  
LSU Tigers 220 LSU
-453 -220 N/A N/A N/A -200 N/A N/A N/A -425  
Final
Clemson Tigers 219 Clemson
+10.5 -114 N/A N/A N/A N/A +3.5 -112 +2.5 +105 N/A N/A +10 -102  
LSU Tigers 220 LSU
-10.5 -109 N/A N/A N/A N/A -3.5 -108 -2.5 -135 N/A N/A -10 -118  
Final
Clemson Tigers 219 Clemson
o50.5 -113 o13 -120 N/A N/A N/A o13.5 -132 o13.5 -130 N/A N/A o48.5 -108  
LSU Tigers 220 LSU
u50.5 -110 u13 -120 N/A N/A N/A u13.5 +108 u13.5 even N/A N/A u48.5 -112  
Final
Clemson Tigers 219 Clemson
+328 +170 N/A N/A N/A +200 N/A N/A N/A +330  
LSU Tigers 220 LSU
-453 -230 N/A N/A N/A -245 N/A N/A N/A -425  
Final
Clemson Tigers 219 Clemson
+10.5 -114 N/A N/A N/A N/A +2.5 -108 +2.5 -110 N/A N/A +10 -102  
LSU Tigers 220 LSU
-10.5 -109 N/A N/A N/A N/A -2.5 -112 -2.5 -120 N/A N/A -10 -118  
Final
Clemson Tigers 219 Clemson
o50.5 -113 o10.5 -120 N/A N/A N/A o10.5 +112 o9.5 -140 N/A N/A o48.5 -108  
LSU Tigers 220 LSU
u50.5 -110 u10.5 -120 N/A N/A N/A u10.5 -136 u9.5 +110 N/A N/A u48.5 -112  
Final
Clemson Tigers 219 Clemson
+328 +195 N/A N/A N/A +168 N/A N/A N/A +330  
LSU Tigers 220 LSU
-453 -270 N/A N/A N/A -220 N/A N/A N/A -425  
Final
Clemson Tigers 219 Clemson
+10.5 -114 N/A N/A N/A N/A N/A N/A N/A N/A +10 -102  
LSU Tigers 220 LSU
-10.5 -109 N/A N/A N/A N/A N/A N/A N/A N/A -10 -118  
Final
Clemson Tigers 219 Clemson
o50.5 -113 N/A N/A N/A N/A N/A o23.5 -120 N/A N/A o48.5 -108  
LSU Tigers 220 LSU
u50.5 -110 N/A N/A N/A N/A N/A u23.5 -110 N/A N/A u48.5 -112  
Final
Clemson Tigers 219 Clemson
+328 N/A N/A N/A N/A N/A N/A N/A N/A +330  
LSU Tigers 220 LSU
-453 N/A N/A N/A N/A N/A N/A N/A N/A -425  

The Clemson Tigers opened as a +10 point underdog to LSU. The total is set at over/under 50.5 total points scored by both teams combined.

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Updated on 10/18/26

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Clemson vs. LSU Prediction

Lane Kiffin brought over a good amount of talent from his defensive line at Ole Miss, and Clemson always has NFL-level talent on the defensive side of the ball. Both of these offensive lines aren't particularly strong, and I expect both (lackluster) quarterbacks to be running for their lives.

Our first major primetime game should be be a low-scoring affair.

bet clemson/lsu under now

Clemson vs. LSU Prediction: u51.5 (-115)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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