College Football Odds Week 10: Kansas vs Iowa State Lines, Spreads, Betting Trends
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Week 10 of the college football season continues with a Big 12 clash between Kansas and Iowa State. The Jayhawks are listed as 2.5 underdogs in their first week ranked in the Top 25, according to the betting odds. Coverage begins from Jack Trice Stadium in Ames, Iowa on Saturday, November 4 at 7:00 p.m. ET on ESPN.
Here's everything you need to know about the college football odds for Week 10 Kansas vs Iowa State: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.
No. 22 Kansas vs Iowa State Odds

- Opening point spread: Pick
- Opening moneyline: Iowa State -135/Kansas +115
- Opening total: Over/Under 54 points scored
- Time: 7 p.m. ET Saturday (ESPN)
UPDATE 2 P.M. ET FRIDAY: Iowa State hasn't budged off -2.5 (-115) all week at BetMGM. Spread tickets are running 2/1 and spread money almost 4/1 on the Cyclones.
The total has seen some movement, dropping from 54.5 (Under -115) to 53 Wednesday, then rising a tick to 53.5 Thursday. The Under is getting a small majority 53% of tickets, while 71% of cash is on the Over.
UPDATE 3 P.M. ET MONDAY: Kansas notched a big upset that could have negative ramifications for the Big 12 – including not getting a team into the College Football Playoff, depending on how things shake out. The Jayhawks (6-2 SU/4-4 ATS) got a last-minute TD in a wild battle against previously unbeaten Oklahoma, scoring a 38-33 win as 7.5-point home underdogs.
Iowa State (5-3 SU and ATS) is on a three-game SU and ATS upswing. In Week 9, the Cyclones went to Baylor as 3-point faves and emerged with a 30-18 victory.
Perhaps surprisingly, this line shot from pick 'em to Iowa State -2.5 by late Sunday night at Caesars, with stops at -1 and -1.5 along the way.
Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 10 Report containing spreads, lines, and trends for every Top 25 matchup.
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