2025 College Football Odds Week 11: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

4 minute read

The College Football Odds Week 11 market doesn't necessarily include a marquee matchup. But there are most certainly key contests that will impact College Football Playoff odds.

Perhaps the most intriguing game in college football Week 11 odds: BYU vs. Texas Tech in the Big 12. Indiana aims to keep rolling, as well, at Penn State.

Here’s everything you need to know about college football odds Week 11: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 11 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Troy Wayrynen/Imagn Images)

2025 College Football Odds for Week 11

BYU vs. Texas Tech Odds

• Opening point spread: Texas Tech -10
• Opening moneyline: Texas Tech TBA/BYU TBA
• Opening total: Over/Under 53.5 points scored
• Time: Noon ET Saturday (ABC)

OPENING ODDS UPDATE: No. 8 BYU (8-0 SU/6-2 ATS) leads the Big 12 in pursuit of a CFP bid and is coming off a bye week. In Week 9, the Cougars trailed Iowa State 24-10 late in the second quarter, then scored 31 of the final 34 points in a 41-27 victory as 2.5-point road underdogs.

No. 9 Texas Tech (8-1 SU/7-2 ATS) bounced back from a Week 8 loss at Arizona State by posting two wins. In Week 10 at Kansas State, the Red Raiders were 7-point favorites and rolled to a 43-20 victory, putting up 31 second-half points.

Circa Sports, whose opening numbers often take sharp play, set Texas Tech as 10-point home chalk in Week 11 college football odds. Shortly thereafter Sunday afternoon, the Red Raiders advanced to -10.5.

Indiana vs. Penn State Odds

• Opening point spread: Indiana -13
• Opening moneyline: Indiana TBA/Penn State TBA
• Opening total: Over/Under 47.5 points scored
• Time: Noon ET Saturday (TV TBA)

OPENING ODDS UPDATE: No. 2 Indiana (9-0 SU/6-3 ATS) just might find itself atop the first CFP rankings this week, though it'll still trail Ohio State in College Football Playoff odds. In Week 10, the Hoosiers smashed Maryland 55-10 laying 21.5 points on the road.

On the other hand, Penn State (3-5 SU/1-7 ATS) is on a five-game slide, during which coach James Franklin was fired. And the Nittany Lions are tied for the worst ATS record in the nation.

In Week 10, Penn State hung around at Ohio State until halftime, trailing 17-14. But that was it for the Nittany Lions in a 38-14 loss catching 17.5 points.

Indiana opened -13.5 in Circa's college football odds Week 11 market. There was no early movement on the spread Sunday, but the total was off and running, from 47.5 straight to 49, then to 49.5.

Texas A&M vs. Missouri Odds

• Opening point spread: Texas A&M -7
• Opening moneyline: Texas A&M TBA/Missouri TBA
• Opening total: Over/Under 50.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 3 Texas A&M (8-0 SU/4-4 ATS) resumes its hard charge toward a spot in the SEC championship game and high CFP seed. The Aggies had a bye in Week 10, after thumping LSU 49-25 giving 1.5 points on the road in Week 9.

No. 19 Missouri (6-2 SU/5-3 ATS) can't take another SEC loss, having already fallen to Alabama and Vanderbilt. Like A&M, the Tigers are coming off a bye, following their 17-10 loss catching 3 points at Vandy. Mizzou had a final-seconds Hail Mary that came up 1 yard short.

Circa opened A&M -7 and the line quickly moved to -6 early Sunday afternoon. The total was also on the move right away, from 50.5 down to 49 in college football Week 11 odds.

LSU vs. Alabama Odds

• Opening point spread: Alabama -11
• Opening moneyline: Alabama TBA/LSU TBA
• Opening total: Over/Under 51.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 4 Alabama (7-1 SU/5-3 ATS) got a much-needed week off after facing four straight ranked opponents, and taking down all four (3-1 ATS).

In Week 9, the Crimson Tide narrowly averted their second loss of the season. Trailing South Carolina 22-14 with 10 minutes left, 'Bama rallied for a pair of touchdowns to escape with a 29-22 win as 12.5-point road favorites.

LSU (5-3 SU/3-5 ATS) also had a bye last week, and needed it. The Tigers are on a 1-3 SU and ATS skid that cost Brian Kelly his job. In Week 9, LSU was a 1.5-point home 'dog and got trucked by Texas A&M 49-25, after which Kelly was fired.

Alabama hasn't moved off Circa Sports' -11 opener in the college football odds Week 11 market. But the total dropped from 51.5 to 49.5 in short order Sunday, then settled at 50 after about an hour.

Navy vs. Notre Dame Odds

• Opening point spread: Notre Dame -26
• Opening moneyline: Notre Dame TBA/Navy TBA
• Opening total: Over/Under 56.5 points scored
• Time: 7:30 p.m. ET Saturday (NBC)

OPENING ODDS UPDATE: No. 10 Notre Dame (6-2 SU/3-4-1 ATS) lost its first two games, but is now cruising toward a potential CFP bid. In Week 10, the Fighting Irish took care of Boston College 25-10, though they fell miles short of covering a hefty 31.5-point spread.

Navy (7-1 SU/2-6 ATS) just took its first loss of the season. The Midshipmen were 6.5-point pups at North Texas and tumbled 31-17.

Circa Sports opened Notre Dame as 26-point home chalk early Sunday afternoon ET, with no movement so far. The total is stable, as well, at 56.5.

Wake Forest vs. Virginia Odds

• Opening point spread: Virginia -7.5
• Opening moneyline: Virginia TBA/Wake Forest TBA
• Opening total: Over/Under 50.5 points scored
• Time: 7 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: Virginia (8-1 SU/6-3 ATS) is now atop the ACC, after Georgia Tech's Week 10 upset loss to N.C. State. The Cavaliers did their part, beating California 31-21 as 5.5-point road underdogs.

Virginia is on a 7-0 SU/5-2 ATS roll.

Wake Forest (5-3 SU and ATS) saw its three-game SU and four-game ATS streaks go up in smoke in Week 10. The Demon Deacons got waxed 42-7 catching 12.5 points at Florida State.

Circa opened Wake-Virginia at Cavaliers -7.5 early Sunday afternoon in college football Week 11 odds. Within minutes, the first move went toward the Demon Deacons, with Virginia nudging to -7. The total saw a bigger move, from 50.5 down to 49.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson