College Football Odds Week 6: Arizona vs USC Lines, Spreads, Betting Trends

Patrick Everson Sports Betting Expert

1 minute read

Week 6 of college football concludes with a Pac-12 showdown between Arizona and USC. The Trojans will try to remain undefeated as 21-point home favorites against the Wildcats. Coverage begins from Los Angeles Memorial Stadium on Saturday, October 7 at 10:30 p.m. ET on ESPN.

Here's everything you need to know about the college football odds for Week 6 Arizona vs USC: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Arizona vs No. 9 USC Odds

• Opening point spread: USC -21
• Opening moneyline: USC -2400/Arizona +1150
• Opening total: Over/Under 72 points scored
• Time: 10:30 p.m. ET Saturday (ESPN)

UPDATE 2 P.M. ET FRIDAY: With Hawaii not playing this week, Arizona-USC is the last game in the college football odds Week 6 market. Or as some might term it: The get-even or get-even-deeper game.

BetMGM was nailed to Southern Cal -21.5 all week, then in the past hour nudged down to -21. Spread tickets are actually 2/1-plus on underdog Arizona, while spread money is 3/1-plus on USC.

The total dipped from 72.5 to 71.5 Tuesday and hasn't budged since. The Over is netting 58% of tickets/69% of cash at BetMGM.

UPDATE 3 P.M. ET MONDAY: Southern Cal (5-0 SU/2-3 ATS) led Colorado by 27 points three times, including 48-21 late in the third quarter. Caleb Williams already had six TD passes at that point.

But the Trojans had to hang on for a 48-41 victory, failing to cash as 21.5-point road favorites. It was a bookmaker's delight, as most shops needed a USC win and a Colorado cover, to bust up once-again-massive Buffaloes moneyline action.

Arizona (3-2 SU/4-1 ATS) has been pretty good to spread bettors thus far, with Week 5 another example. The Wildcats spotted No. 7 Washington a 14-0 lead, but stayed within the 20-point spread throughout in a 31-24 loss.

USC climbed to -21.5 and -22 Sunday in Caesars' college football odds Week 6 market. The number backed up a notch this morning to Trojans -21.5.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 6 Report containing spreads, lines, and trends for every Top 25 matchup.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson