College Football Odds Week 6: Arizona vs USC Lines, Spreads, Betting Trends

Matchup Spread Total Moneyline
USC vs
-21.5 (-110)
+21.5 (-110)
o69.5 (-105)
u69.5 (-115)

Week 6 of college football concludes with a Pac-12 showdown between Arizona and USC. The Trojans will try to remain undefeated as 21-point home favorites against the Wildcats. Coverage begins from Los Angeles Memorial Stadium on Saturday, October 7 at 10:30 p.m. ET on ESPN.

Here's everything you need to know about the college football odds for Week 6 Arizona vs USC: the opening lines, spreads, betting trends and more. Check back regularly for updates.

Arizona vs No. 9 USC Odds

  • Opening point spread: USC -21
  • Opening moneyline: USC -2400/Arizona +1150
  • Opening total: Over/Under 72 points scored
  • Time: 10:30 p.m. ET Saturday (ESPN)

UPDATE 2 P.M. ET FRIDAY: With Hawaii not playing this week, Arizona-USC is the last game in the college football odds Week 6 market. Or as some might term it: The get-even or get-even-deeper game.

BetMGM was nailed to Southern Cal -21.5 all week, then in the past hour nudged down to -21. Spread tickets are actually 2/1-plus on underdog Arizona, while spread money is 3/1-plus on USC.

The total dipped from 72.5 to 71.5 Tuesday and hasn't budged since. The Over is netting 58% of tickets/69% of cash at BetMGM.

UPDATE 3 P.M. ET MONDAY: Southern Cal (5-0 SU/2-3 ATS) led Colorado by 27 points three times, including 48-21 late in the third quarter. Caleb Williams already had six TD passes at that point.

But the Trojans had to hang on for a 48-41 victory, failing to cash as 21.5-point road favorites. It was a bookmaker's delight, as most shops needed a USC win and a Colorado cover, to bust up once-again-massive Buffaloes moneyline action.

Arizona (3-2 SU/4-1 ATS) has been pretty good to spread bettors thus far, with Week 5 another example. The Wildcats spotted No. 7 Washington a 14-0 lead, but stayed within the 20-point spread throughout in a 31-24 loss.

USC climbed to -21.5 and -22 Sunday in Caesars' college football odds Week 6 market. The number backed up a notch this morning to Trojans -21.5.

Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 6 Report containing spreads, lines, and trends for every Top 25 matchup.