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Featured Last Updated Sep 25 2025, 1:30 PM

Illinois vs. USC: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
8 minute read
Illinois vs. USC: Prediction, Odds, Best Bet

Image Credit: Gary A. Vasquez via Imagn Images

USC @ ILL Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
USC Trojans 181 USC
-1.5 -110 -3.5 -105 + -3 -115 + -3.5 +102 + -3 -110 + -3.5 even + -3.5 -108 + -3.5 -105 -3.5 -105 + -7 -105  
Illinois Fighting Illini 182 Illinois
+1.5 -110 +3.5 -115 + +3 -105 + +3.5 -122 + +3 -110 + +3.5 -130 + +3.5 -112 + +3.5 -115 +3.5 -127 + +7 -115  
USC Trojans 181 USC
o59.5 -110 o30.5 -115 + N/A o30.5 -115 + o30.5 -120 + N/A o30.5 -110 + o30.5 -110 o29.5 -122 + o60.5 -115  
Illinois Fighting Illini 182 Illinois
u59.5 -110 u30.5 -105 + N/A u30.5 -105 + u30.5 even + N/A u30.5 -110 + u30.5 -110 u29.5 -107 + u60.5 -105  
USC Trojans 181 USC
-218 -190 + N/A -175 + -170 + -190 + -205 + N/A -195 + -250  
Illinois Fighting Illini 182 Illinois
+180 +160 + N/A +145 + +143 + +140 + +164 + N/A +148 + +205  
USC Trojans 181 USC
-1.5 -110 -0.5 -125 + -0.5 -118 + -2.5 -115 + -0.5 -130 + -1.5 -110 + -1.5 -104 + -2.5 -120 -2.5 -118 + -7 -105  
Illinois Fighting Illini 182 Illinois
+1.5 -110 +0.5 -105 + +0.5 -110 + +2.5 -105 + +0.5 even + +1.5 -120 + +1.5 -120 + +2.5 -110 +2.5 -110 + +7 -115  
USC Trojans 181 USC
o59.5 -110 o13.5 -110 + N/A o13.5 -108 + o13.5 -105 + o13.5 -120 + o13.5 -130 + o13.5 -120 o13.5 -121 + o60.5 -115  
Illinois Fighting Illini 182 Illinois
u59.5 -110 u13.5 -120 + N/A u13.5 -112 + u13.5 -125 + u13.5 -110 + u13.5 +104 + u13.5 -110 u13.5 -108 + u60.5 -105  
USC Trojans 181 USC
-218 -165 + N/A -175 + -170 + -190 + -180 + N/A -186 + -250  
Illinois Fighting Illini 182 Illinois
+180 +135 + N/A +145 + +140 + +140 + +142 + N/A +145 + +205  
USC Trojans 181 USC
-1.5 -110 N/A N/A -4.5 -102 + -3.5 even + N/A N/A N/A N/A -7 -105  
Illinois Fighting Illini 182 Illinois
+1.5 -110 N/A N/A +4.5 -118 + +3.5 -120 + N/A N/A N/A N/A +7 -115  
USC Trojans 181 USC
o59.5 -110 N/A N/A o29.5 -110 + o28.5 even + N/A N/A N/A N/A o60.5 -115  
Illinois Fighting Illini 182 Illinois
u59.5 -110 N/A N/A u29.5 -110 + u28.5 -120 + N/A N/A N/A N/A u60.5 -105  
USC Trojans 181 USC
-218 N/A N/A -218 + N/A N/A N/A N/A N/A -250  
Illinois Fighting Illini 182 Illinois
+180 N/A N/A +180 + N/A N/A N/A N/A N/A +205  
USC Trojans 181 USC
-1.5 -110 N/A N/A -0.5 -115 + N/A N/A -2.5 -118 + N/A N/A -7 -105  
Illinois Fighting Illini 182 Illinois
+1.5 -110 N/A N/A +0.5 -115 + N/A N/A +2.5 -114 + N/A N/A +7 -115  
USC Trojans 181 USC
o59.5 -110 o17 -115 + N/A o17.5 +110 + N/A N/A o17.5 +116 + N/A N/A o60.5 -115  
Illinois Fighting Illini 182 Illinois
u59.5 -110 u17 -115 + N/A u17.5 -140 + N/A N/A u17.5 -145 + N/A N/A u60.5 -105  
USC Trojans 181 USC
-218 -165 + N/A -140 + N/A N/A -180 + N/A N/A -250  
Illinois Fighting Illini 182 Illinois
+180 +135 + N/A +110 + N/A N/A +142 + N/A N/A +205  
USC Trojans 181 USC
-1.5 -110 N/A N/A -1.5 -115 + N/A N/A -1.5 +104 + N/A N/A -7 -105  
Illinois Fighting Illini 182 Illinois
+1.5 -110 N/A N/A +1.5 -115 + N/A N/A +1.5 -138 + N/A N/A +7 -115  
USC Trojans 181 USC
o59.5 -110 o13.5 -125 + N/A o13.5 -135 + N/A N/A o13.5 -135 + N/A N/A o60.5 -115  
Illinois Fighting Illini 182 Illinois
u59.5 -110 u13.5 -105 + N/A u13.5 +105 + N/A N/A u13.5 +108 + N/A N/A u60.5 -105  
USC Trojans 181 USC
-218 -170 + N/A -200 + N/A N/A -164 + N/A N/A -250  
Illinois Fighting Illini 182 Illinois
+180 +140 + N/A +154 + N/A N/A +128 + N/A N/A +205  
USC Trojans 181 USC
-1.5 -110 -0.5 even + N/A -0.5 -125 + N/A N/A -1.5 +102 + N/A N/A -7 -105  
Illinois Fighting Illini 182 Illinois
+1.5 -110 +0.5 -130 + N/A +0.5 -105 + N/A N/A +1.5 -136 + N/A N/A +7 -115  
USC Trojans 181 USC
o59.5 -110 o16 -115 + N/A o15.5 -110 + N/A N/A o14.5 -106 + N/A N/A o60.5 -115  
Illinois Fighting Illini 182 Illinois
u59.5 -110 u16 -115 + N/A u15.5 -120 + N/A N/A u14.5 -118 + N/A N/A u60.5 -105  
USC Trojans 181 USC
-218 -155 + N/A -166 + N/A N/A -162 + N/A N/A -250  
Illinois Fighting Illini 182 Illinois
+180 +125 + N/A +130 + N/A N/A +126 + N/A N/A +205  

The USC Trojans will take on the Illinois Fighting Illini in this week's NCAAF action. Kickoff is set for 12:00 p.m. EDT at Memorial Stadium (Champaign, IL) in Champaign, Ill. The game will be broadcast live on FOX. Here's everything you need to know about USC vs. Illinois odds, the latest NCAAF spreads, NCAAF over/unders and more.

The USC Trojans opened as a -6.5 point favorite over Illinois. The total is set at over/under 60.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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USC Trojans vs. Illinois Fighting Illini Best Bet

In college football, it's best to take week-to-week results with a grain of salt and try not overreact too much from what happened the week prior.

Illinois will put that to the test after being beaten down by Indiana just a week ago, 63-10, in Bloomington.

We eyed Indiana on the spread in that one - now let's target the Illini in this juicy bounce-back spot.

For the Trojans, this will be their first big test of the season. After beating up on Michigan State with an 11pm kickoff in LA, they now have to take on a laser-focused Illinois squad coming off an embarrassing loss.

This feels like way too many points for an Illinois team that was viewed as a consensus top-10 team that had legitimate CFP hopes just as recently as a week ago.

USC vs. Illinois Best Bet: Illinois +6.5 | Sprinkle Illinois ML

(Pick from Derek Mountain)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the USC vs. Illinois Game?

The Illinois Fighting Illini will take on the USC Trojans at 12:00 ET on Saturday, September 27th.

Where is the Illinois Fighting Illini vs. USC Trojans Game Being Played?

This game is going to be played at Memorial Stadium in Champaign, Illinois.

How Can I Watch USC vs. Illinois?

You can watch Indiana vs. Illinois on FOX.

Can Illinois Beat Indiana?

Absolutely, the Illinois Fighting Illini can certainly pull off the upset this Saturday.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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