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Featured Last Updated Oct 20 2026, 12:10 PM

Indiana vs. Michigan Prediction: Michigan Keeps Big Ten Matchup Close

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Indiana vs. Michigan Prediction: Michigan Keeps Big Ten Matchup Close

Updated on 10/20/26

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The Indiana Hoosiers will take on the Michigan Wolverines in this week's college football action. Kickoff is set for 12:00 p.m. EST at Michigan Stadium in Ann Arbor, MI. The game will be broadcast live on FOX. Here's everything you need to know about Indiana vs. Michigan odds, the latest college football spreads, college football over/unders and more.

IU @ MICH Odds

  • Full Game
  • 1Q
  • 1H
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Indiana Hoosiers 337 Indiana
-6.5 -110 -1.5 -110 + -0.5 -108 + -0.5 even + N/A -1.5 -102 + N/A -0.5 -105 + -1.5 -103 + -7 -112  
Michigan Wolverines 338 Michigan
+6.5 -110 +1.5 -120 + +0.5 -120 + +0.5 -130 + N/A +1.5 -118 + N/A +0.5 -125 + +1.5 -129 + +7 -108  
Indiana Hoosiers 337 Indiana
o52.5 -112 o7.5 even + o7.5 -102 + o7.5 +105 + N/A o7.5 -108 + N/A o7.5 -105 + o7.5 -114 + o41.5 -110  
Michigan Wolverines 338 Michigan
u52.5 -108 u7.5 -130 + u7.5 -125 + u7.5 -135 + N/A u7.5 -114 + N/A u7.5 -125 + u7.5 -115 + u41.5 -110  
Indiana Hoosiers 337 Indiana
-258 -185 + -190 + -180 + N/A -180 + N/A N/A -190 + -278  
Michigan Wolverines 338 Michigan
+210 +145 + +145 + +140 + N/A +154 + N/A N/A +145 + +225  
Indiana Hoosiers 337 Indiana
-6.5 -110 -3.5 -115 + -3.5 -115 + -3.5 -115 + -3.5 -115 + -3.5 -115 + N/A -3.5 -120 + -3.5 -122 + -7 -112  
Michigan Wolverines 338 Michigan
+6.5 -110 +3.5 -105 + +3.5 -105 + +3.5 -105 + +3.5 -106 + +3.5 -105 + N/A +3.5 -110 + +3.5 -109 + +7 -108  
Indiana Hoosiers 337 Indiana
o52.5 -112 o20.5 -113 + o20.5 -112 + o20.5 -112 + o20.5 -114 + o20.5 -114 + N/A o20.5 -120 + o20.5 -122 + o41.5 -110  
Michigan Wolverines 338 Michigan
u52.5 -108 u20.5 -107 + u20.5 -105 + u20.5 -108 + u20.5 -107 + u20.5 -106 + N/A u20.5 -110 + u20.5 -108 + u41.5 -110  
Indiana Hoosiers 337 Indiana
-258 -220 + -210 + -218 + -225 + -220 + N/A N/A -245 + -278  
Michigan Wolverines 338 Michigan
+210 +180 + +170 + +180 + +179 + +178 + N/A N/A +185 + +225  
Indiana Hoosiers 337 Indiana
-6.5 -110 N/A N/A -2.5 -125 + N/A -2.5 -118 + N/A N/A N/A -7 -112  
Michigan Wolverines 338 Michigan
+6.5 -110 N/A N/A +2.5 -105 + N/A +2.5 -102 + N/A N/A N/A +7 -108  
Indiana Hoosiers 337 Indiana
o52.5 -112 o12.5 -120 + N/A o12.5 -130 + N/A o12.5 -116 + N/A N/A N/A o41.5 -110  
Michigan Wolverines 338 Michigan
u52.5 -108 u12.5 -120 + N/A u12.5 even + N/A u12.5 -106 + N/A N/A N/A u41.5 -110  
Indiana Hoosiers 337 Indiana
-258 -200 + N/A -200 + N/A -190 + N/A N/A N/A -278  
Michigan Wolverines 338 Michigan
+210 +150 + N/A +154 + N/A +160 + N/A N/A N/A +225  
Indiana Hoosiers 337 Indiana
-6.5 -110 N/A N/A -0.5 -110 + N/A -1.5 -102 + N/A N/A N/A -7 -112  
Michigan Wolverines 338 Michigan
+6.5 -110 N/A N/A +0.5 -120 + N/A +1.5 -120 + N/A N/A N/A +7 -108  
Indiana Hoosiers 337 Indiana
o52.5 -112 o8.5 -115 + N/A o7.5 even + N/A o8.5 -112 + N/A N/A N/A o41.5 -110  
Michigan Wolverines 338 Michigan
u52.5 -108 u8.5 -125 + N/A u7.5 -130 + N/A u8.5 -108 + N/A N/A N/A u41.5 -110  
Indiana Hoosiers 337 Indiana
-258 -200 + N/A -200 + N/A -194 + N/A N/A N/A -278  
Michigan Wolverines 338 Michigan
+210 +150 + N/A +154 + N/A +150 + N/A N/A N/A +225  
Indiana Hoosiers 337 Indiana
-6.5 -110 -1.5 -115 + N/A -1.5 -115 + N/A -1.5 +102 + N/A N/A N/A -7 -112  
Michigan Wolverines 338 Michigan
+6.5 -110 +1.5 -125 + N/A +1.5 -115 + N/A +1.5 -126 + N/A N/A N/A +7 -108  
Indiana Hoosiers 337 Indiana
o52.5 -112 o10.5 even + N/A o10.5 -110 + N/A o10.5 +102 + N/A N/A N/A o41.5 -110  
Michigan Wolverines 338 Michigan
u52.5 -108 u10.5 -140 + N/A u10.5 -120 + N/A u10.5 -126 + N/A N/A N/A u41.5 -110  
Indiana Hoosiers 337 Indiana
-258 -180 + N/A -188 + N/A -160 + N/A N/A N/A -278  
Michigan Wolverines 338 Michigan
+210 +135 + N/A +145 + N/A +136 + N/A N/A N/A +225  
Indiana Hoosiers 337 Indiana
-6.5 -110 N/A N/A -3.5 -115 + N/A N/A N/A N/A N/A -7 -112  
Michigan Wolverines 338 Michigan
+6.5 -110 N/A N/A +3.5 -105 + N/A N/A N/A N/A N/A +7 -108  
Indiana Hoosiers 337 Indiana
o52.5 -112 N/A N/A o20.5 -108 + N/A N/A N/A N/A N/A o41.5 -110  
Michigan Wolverines 338 Michigan
u52.5 -108 N/A N/A u20.5 -112 + N/A N/A N/A N/A N/A u41.5 -110  
Indiana Hoosiers 337 Indiana
-258 N/A N/A -225 + N/A N/A N/A N/A N/A -278  
Michigan Wolverines 338 Michigan
+210 N/A N/A +185 + N/A N/A N/A N/A N/A +225  

The Indiana Hoosiers opened as a -6.5 point favorite over Michigan. The total is set at over/under 41.5 total points scored by both teams combined.

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Updated on 10/20/26

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Indiana vs. Michigan Prediction

Michigan's defense has been extremely poor this season. However, their defense still ranks as one of the best and most efficient in college football. They rank in the 96th percentile in explosiveness allowed, and they are in the 96th percentile for EPA allowed.

This will be the tallest task Indiana's offense will face this season. Their offense struggled to move the ball against an Ohio State defense who has taken a step back from last season.

Wittingham is keeping the starting QB plans close to his chest, but if the Wolverines decide to start Carr, this immediately upgrades the offense and throws a wrench in Indiana's gameplan. I think the Wolverines keep this one close.

Indiana vs. Michigan Prediction: Michigan Wolverines +7 (-110)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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