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Louisville vs. Ole Miss Odds: Expert Prediction for Louisville vs. Ole Miss

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Louisville vs. Ole Miss Odds: Expert Prediction for Louisville vs. Ole Miss

Updated on 10/18/26

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The Louisville Cardinals will take on the Ole Miss Rebels in this week's college football action. Kickoff is set for 7:30 p.m. EST at Nissan Stadium in Nashville, TN. The game will be broadcast live on ABC. Here's everything you need to know about Louisville vs. Ole Miss odds, the latest college football spreads, college football over/unders and more.

LOU @ MISS Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Final
Louisville Cardinals 229 Louisville
+7 -110 +4.5 -120 N/A +3.5 +120 +4.5 -122 +4.5 -110 +3.5 -110 +3.5 -110 +4.5 -114 +6.5 -108  
Ole Miss Rebels 230 Ole Miss
-7 -113 -4.5 even N/A -3.5 -142 -4.5 +101 -4.5 -110 -3.5 -120 -3.5 -120 -4.5 -109 -6.5 -112  
Final
Louisville Cardinals 229 Louisville
o53.5 -114 o27.5 -110 o27.5 -108 o27.5 -118 o27.5 -110 o27.5 -110 o27.5 -110 o27.5 -110 o27.5 -120 o54.5 -110  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u27.5 -110 u27.5 -110 u27.5 -102 u27.5 -110 u27.5 -110 u27.5 -120 u27.5 -120 u27.5 -109 u54.5 -110  
Final
Louisville Cardinals 229 Louisville
+228 +180 N/A +200 +169 +196 N/A N/A +188 +200  
Ole Miss Rebels 230 Ole Miss
-297 -220 N/A -245 -209 -245 N/A N/A -250 -245  
Final
Louisville Cardinals 229 Louisville
+7 -110 +2.5 -110 N/A +2.5 -105 N/A +3.5 -128 +0.5 -120 +2.5 -110 +3.5 -127 +6.5 -108  
Ole Miss Rebels 230 Ole Miss
-7 -113 -2.5 -120 N/A -2.5 -125 N/A -3.5 +106 -0.5 -110 -2.5 -120 -3.5 -104 -6.5 -112  
Final
Louisville Cardinals 229 Louisville
o53.5 -114 o10.5 -125 o12.5 -118 o10.5 -110 N/A o12.5 -114 o10.5 -105 o10.5 -110 o12.5 -125 o54.5 -110  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u10.5 -105 u12.5 -110 u10.5 -120 N/A u12.5 -108 u10.5 -125 u10.5 -120 u12.5 -105 u54.5 -110  
Final
Louisville Cardinals 229 Louisville
+228 +170 N/A +150 N/A +200 N/A N/A +200 +200  
Ole Miss Rebels 230 Ole Miss
-297 -220 N/A -195 N/A -245 N/A N/A -275 -245  
Final
Louisville Cardinals 229 Louisville
+7 -110 N/A N/A +2.5 -110 N/A N/A N/A N/A N/A +6.5 -108  
Ole Miss Rebels 230 Ole Miss
-7 -113 N/A N/A -2.5 -110 N/A N/A N/A N/A N/A -6.5 -112  
Final
Louisville Cardinals 229 Louisville
o53.5 -114 N/A N/A o26.5 -110 N/A N/A o26.5 -130 N/A N/A o54.5 -110  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 N/A N/A u26.5 -110 N/A N/A u26.5 -110 N/A N/A u54.5 -110  
Final
Louisville Cardinals 229 Louisville
+228 N/A N/A +136 N/A N/A N/A N/A N/A +200  
Ole Miss Rebels 230 Ole Miss
-297 N/A N/A -162 N/A N/A N/A N/A N/A -245  
Final
Louisville Cardinals 229 Louisville
+7 -110 N/A N/A +1.5 -115 N/A +2.5 -108 +1.5 -115 N/A N/A +6.5 -108  
Ole Miss Rebels 230 Ole Miss
-7 -113 N/A N/A -1.5 -115 N/A -2.5 -114 -1.5 -115 N/A N/A -6.5 -112  
Final
Louisville Cardinals 229 Louisville
o53.5 -114 o14 -120 N/A o16.5 -120 N/A o15.5 -116 o14.5 -115 N/A N/A o54.5 -110  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u14 -120 N/A u16.5 -110 N/A u15.5 -106 u14.5 -115 N/A N/A u54.5 -110  
Final
Louisville Cardinals 229 Louisville
+228 +120 N/A +124 N/A +146 N/A N/A N/A +200  
Ole Miss Rebels 230 Ole Miss
-297 -160 N/A -160 N/A -172 N/A N/A N/A -245  
Final
Louisville Cardinals 229 Louisville
+7 -110 N/A N/A +0.5 -125 N/A +1.5 -146 +0.5 -115 N/A N/A +6.5 -108  
Ole Miss Rebels 230 Ole Miss
-7 -113 N/A N/A -0.5 -105 N/A -1.5 +120 -0.5 -115 N/A N/A -6.5 -112  
Final
Louisville Cardinals 229 Louisville
o53.5 -114 o13.5 -120 N/A o10.5 -110 N/A o10.5 -104 o10.5 -115 N/A N/A o54.5 -110  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u13.5 -120 N/A u10.5 -120 N/A u10.5 -116 u10.5 -115 N/A N/A u54.5 -110  
Final
Louisville Cardinals 229 Louisville
+228 +165 N/A +130 N/A +112 N/A N/A N/A +200  
Ole Miss Rebels 230 Ole Miss
-297 -225 N/A -166 N/A -142 N/A N/A N/A -245  
Final
Louisville Cardinals 229 Louisville
+7 -110 +2.5 -120 N/A +0.5 -130 N/A +1.5 -126 +0.5 -130 N/A N/A +6.5 -108  
Ole Miss Rebels 230 Ole Miss
-7 -113 -2.5 -120 N/A -0.5 even N/A -1.5 +104 -0.5 even N/A N/A -6.5 -112  
Final
Louisville Cardinals 229 Louisville
o53.5 -114 o14 -120 N/A o13.5 -140 N/A o13.5 -126 o14.5 +120 N/A N/A o54.5 -110  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u14 -120 N/A u13.5 +110 N/A u13.5 +104 u14.5 -160 N/A N/A u54.5 -110  
Final
Louisville Cardinals 229 Louisville
+228 +140 N/A +114 N/A +126 N/A N/A N/A +200  
Ole Miss Rebels 230 Ole Miss
-297 -190 N/A -145 N/A -148 N/A N/A N/A -245  

The Ole Miss Rebels opened as a -6.5 point favorite over Ole Miss. The total is set at over/under 55.5 total points scored by both teams combined.

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Updated on 10/18/26

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Louisville vs. Ole Miss Prediction

Lane Kiffin took all of Ole Miss' defensive-line talent with him to LSU, leaving Ole Miss with leftover talent. The rest of their defense isn't strong either. I expect Lincoln Kienholz to make an impact for Louisville immediately, leading them to a massive win to open their season.

Louisville vs. Ole Miss Prediction: Louisville Cardinals +7 (-112) & Louisville Moneyline (+225)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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