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Featured Last Updated Sep 3 2026, 10:48 AM

Louisville vs. Ole Miss Odds: Expert Prediction for Louisville vs. Ole Miss

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
14 minute read
Louisville vs. Ole Miss Odds: Expert Prediction for Louisville vs. Ole Miss

Updated on 9/3/26

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The Louisville Cardinals will take on the Ole Miss Rebels in this week's college football action. Kickoff is set for 7:30 p.m. EST at Nissan Stadium in Nashville, TN. The game will be broadcast live on ABC. Here's everything you need to know about Louisville vs. Ole Miss odds, the latest college football spreads, college football over/unders and more.

LOU @ MISS Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Louisville Cardinals 229 Louisville
+7 -110 +4.5 -115 + N/A +4.5 -115 + +4.5 -118 + +4.5 -118 + +3.5 -105 + +3.5 -105 + +4.5 -118 + +6.5 -102  
Ole Miss Rebels 230 Ole Miss
-7 -113 -4.5 -105 + N/A -4.5 -105 + -4.5 -104 + -4.5 -104 + -3.5 -125 + -3.5 -125 + -4.5 -105 + -6.5 -118  
Louisville Cardinals 229 Louisville
o53.5 -114 o28.5 -105 + o28.5 -108 + o28.5 -105 + o27.5 -124 + o27.5 -112 + o27.5 -125 + o27.5 -125 + o27.5 -127 + o55.5 -105  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u28.5 -115 + u28.5 -110 + u28.5 -115 + u27.5 +101 + u27.5 -108 + u27.5 -105 + u27.5 -105 + u27.5 even + u55.5 -115  
Louisville Cardinals 229 Louisville
+228 +185 + N/A +190 + +185 + +180 + N/A N/A +170 + +220  
Ole Miss Rebels 230 Ole Miss
-297 -225 + N/A -230 + -235 + -225 + N/A N/A -235 + -270  
Louisville Cardinals 229 Louisville
+7 -110 +2.5 even + N/A +2.5 -105 + N/A +2.5 -104 + +1.5 -115 + +2.5 -110 + +2.5 -110 + +6.5 -102  
Ole Miss Rebels 230 Ole Miss
-7 -113 -2.5 -130 + N/A -2.5 -125 + N/A -2.5 -118 + -1.5 -115 + -2.5 -120 + -2.5 -115 + -6.5 -118  
Louisville Cardinals 229 Louisville
o53.5 -114 o12.5 -120 + o12.5 -120 + o11.5 -115 + N/A o12.5 -116 + o10.5 -120 + o13.5 -105 + o13.5 -108 + o55.5 -105  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u12.5 -110 + u12.5 -105 + u11.5 -115 + N/A u12.5 -106 + u10.5 -105 + u13.5 -125 + u13.5 -120 + u55.5 -115  
Louisville Cardinals 229 Louisville
+228 +175 + N/A +170 + N/A +168 + N/A N/A +160 + +220  
Ole Miss Rebels 230 Ole Miss
-297 -230 + N/A -220 + N/A -200 + N/A N/A -205 + -270  
Louisville Cardinals 229 Louisville
+7 -110 N/A N/A +2.5 -105 + N/A N/A N/A N/A N/A +6.5 -102  
Ole Miss Rebels 230 Ole Miss
-7 -113 N/A N/A -2.5 -115 + N/A N/A N/A N/A N/A -6.5 -118  
Louisville Cardinals 229 Louisville
o53.5 -114 N/A N/A o26.5 -110 + N/A N/A o26.5 -125 + N/A N/A o55.5 -105  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 N/A N/A u26.5 -110 + N/A N/A u26.5 -105 + N/A N/A u55.5 -115  
Louisville Cardinals 229 Louisville
+228 N/A N/A +142 + N/A N/A N/A N/A N/A +220  
Ole Miss Rebels 230 Ole Miss
-297 N/A N/A -170 + N/A N/A N/A N/A N/A -270  
Louisville Cardinals 229 Louisville
+7 -110 N/A N/A +2.5 -115 + N/A +2.5 -106 + +2.5 -110 + N/A N/A +6.5 -102  
Ole Miss Rebels 230 Ole Miss
-7 -113 N/A N/A -2.5 -115 + N/A -2.5 -116 + -2.5 -115 + N/A N/A -6.5 -118  
Louisville Cardinals 229 Louisville
o53.5 -114 o16.5 -120 + N/A o16.5 -125 + N/A o16.5 -106 + o16.5 -110 + N/A N/A o55.5 -105  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u16.5 -120 + N/A u16.5 -105 + N/A u16.5 -116 + u16.5 -115 + N/A N/A u55.5 -115  
Louisville Cardinals 229 Louisville
+228 +110 + N/A +130 + N/A +148 + N/A N/A N/A +220  
Ole Miss Rebels 230 Ole Miss
-297 -150 + N/A -166 + N/A -174 + N/A N/A N/A -270  
Louisville Cardinals 229 Louisville
+7 -110 N/A N/A +0.5 -120 + N/A +1.5 -122 + +0.5 -115 + N/A N/A +6.5 -102  
Ole Miss Rebels 230 Ole Miss
-7 -113 N/A N/A -0.5 -110 + N/A -1.5 -100 + -0.5 -110 + N/A N/A -6.5 -118  
Louisville Cardinals 229 Louisville
o53.5 -114 o13.5 -120 + N/A o10.5 -110 + N/A o12.5 -110 + o10.5 -115 + N/A N/A o55.5 -105  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u13.5 -120 + N/A u10.5 -120 + N/A u12.5 -110 + u10.5 -110 + N/A N/A u55.5 -115  
Louisville Cardinals 229 Louisville
+228 +125 + N/A +135 + N/A +136 + N/A N/A N/A +220  
Ole Miss Rebels 230 Ole Miss
-297 -165 + N/A -175 + N/A -174 + N/A N/A N/A -270  
Louisville Cardinals 229 Louisville
+7 -110 +0.5 -135 + N/A +0.5 -125 + N/A +1.5 -122 + +0.5 -130 + N/A N/A +6.5 -102  
Ole Miss Rebels 230 Ole Miss
-7 -113 -0.5 -105 + N/A -0.5 -105 + N/A -1.5 -100 + -0.5 even + N/A N/A -6.5 -118  
Louisville Cardinals 229 Louisville
o53.5 -114 o14 -115 + N/A o14.5 +110 + N/A o13.5 -128 + o14.5 +125 + N/A N/A o55.5 -105  
Ole Miss Rebels 230 Ole Miss
u53.5 -109 u14 -125 + N/A u14.5 -140 + N/A u13.5 +106 + u14.5 -160 + N/A N/A u55.5 -115  
Louisville Cardinals 229 Louisville
+228 even + N/A +110 + N/A +130 + N/A N/A N/A +220  
Ole Miss Rebels 230 Ole Miss
-297 -140 + N/A -140 + N/A -152 + N/A N/A N/A -270  

The Ole Miss Rebels opened as a -6.5 point favorite over Ole Miss. The total is set at over/under 55.5 total points scored by both teams combined.

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Updated on 9/3/26

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Louisville vs. Ole Miss Prediction

Lane Kiffin took all of Ole Miss' defensive-line talent with him to LSU, leaving Ole Miss with leftover talent. The rest of their defense isn't strong either. I expect Lincoln Kienholz to make an impact for Louisville immediately, leading them to a massive win to open their season.

Louisville vs. Ole Miss Prediction: Louisville Cardinals +7 (-112) & Louisville Moneyline (+225)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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