Sign Up Subscribe
Featured Last Updated Oct 9 2025, 5:23 PM

Michigan vs. USC: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
8 minute read
Michigan vs. USC: Prediction, Odds, Best Bet

Image Credit: Rick Osentoski-Imagn Images

MICH @ USC Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Michigan Wolverines 171 Michigan
-1.5 -110 +0.5 -115 + +0.5 -110 + +0.5 -112 + +0.5 -115 + +0.5 -120 + +2.5 -110 + +0.5 -110 + +0.5 -115 +1.5 -121 + +2.5 -108  
USC Trojans 172 USC
+1.5 -110 -0.5 -105 + -0.5 -110 + -0.5 -108 + -0.5 -105 + -0.5 -110 + -2.5 -110 + -0.5 -110 + -0.5 -105 -1.5 -104 + -2.5 -112  
Michigan Wolverines 171 Michigan
o54.5 -112 o28 -105 + N/A o28.5 even + o28 -105 + N/A o28.5 -100 + o27.5 -115 + o27.5 -115 o27.5 -124 + o56.5 -108  
USC Trojans 172 USC
u54.5 -108 u28 -115 + N/A u28.5 -120 + u28 -115 + N/A u28.5 -122 + u27.5 -105 + u27.5 -105 u27.5 -105 + u56.5 -112  
Michigan Wolverines 171 Michigan
+110 even + +105 + +105 + +105 + even + +118 + N/A N/A +102 + +110  
USC Trojans 172 USC
-130 -120 + -125 + -125 + -125 + -130 + -144 + N/A N/A -132 + -130  
Michigan Wolverines 171 Michigan
-1.5 -110 +0.5 -140 + +0.5 -140 + +0.5 -135 + +0.5 -135 + +0.5 -135 + +1.5 -128 + +0.5 -140 + -0.5 +150 +1.5 -165 + +2.5 -108  
USC Trojans 172 USC
+1.5 -110 -0.5 +110 + -0.5 +110 + -0.5 +105 + -0.5 +105 + -0.5 +105 + -1.5 +102 + -0.5 +110 + +0.5 -210 -1.5 +125 + -2.5 -112  
Michigan Wolverines 171 Michigan
o54.5 -112 o12.5 -125 + N/A o13.5 -110 + o12.5 -130 + o12.5 -125 + o12.5 -118 + o13.5 -115 + o10.5 -125 o12.5 -115 + o56.5 -108  
USC Trojans 172 USC
u54.5 -108 u12.5 -105 + N/A u13.5 -120 + u12.5 even + u12.5 -105 + u12.5 -106 + u13.5 -115 + u10.5 -105 u12.5 -113 + u56.5 -112  
Michigan Wolverines 171 Michigan
+110 -105 + +110 + +120 + +105 + +120 + +122 + N/A N/A -103 + +110  
USC Trojans 172 USC
-130 -125 + -140 + -154 + -135 + -150 + -156 + N/A N/A -127 + -130  
Michigan Wolverines 171 Michigan
-1.5 -110 N/A N/A +1.5 -130 + +0.5 -120 + N/A N/A N/A N/A N/A +2.5 -108  
USC Trojans 172 USC
+1.5 -110 N/A N/A -1.5 +110 + -0.5 even + N/A N/A N/A N/A N/A -2.5 -112  
Michigan Wolverines 171 Michigan
o54.5 -112 N/A N/A o27.5 -110 + o27.5 -110 + N/A N/A o27.5 -120 + N/A N/A o56.5 -108  
USC Trojans 172 USC
u54.5 -108 N/A N/A u27.5 -110 + u27.5 -110 + N/A N/A u27.5 -110 + N/A N/A u56.5 -112  
Michigan Wolverines 171 Michigan
+110 N/A N/A +105 + N/A N/A N/A N/A N/A N/A +110  
USC Trojans 172 USC
-130 N/A N/A -125 + N/A N/A N/A N/A N/A N/A -130  
Michigan Wolverines 171 Michigan
-1.5 -110 N/A N/A -0.5 +105 + N/A N/A +1.5 -146 + +0.5 -135 + N/A N/A +2.5 -108  
USC Trojans 172 USC
+1.5 -110 N/A N/A +0.5 -135 + N/A N/A -1.5 +110 + -0.5 +105 + N/A N/A -2.5 -112  
Michigan Wolverines 171 Michigan
o54.5 -112 o15.5 -115 + N/A o16.5 -115 + N/A N/A o16.5 -120 + o15.5 -115 + N/A N/A o56.5 -108  
USC Trojans 172 USC
u54.5 -108 u15.5 -115 + N/A u16.5 -115 + N/A N/A u16.5 -104 + u15.5 -115 + N/A N/A u56.5 -112  
Michigan Wolverines 171 Michigan
+110 -110 + N/A -125 + N/A N/A +104 + N/A N/A N/A +110  
USC Trojans 172 USC
-130 -120 + N/A -105 + N/A N/A -132 + N/A N/A N/A -130  
Michigan Wolverines 171 Michigan
-1.5 -110 N/A N/A +0.5 -154 + N/A N/A +1.5 -182 + +0.5 -160 + N/A N/A +2.5 -108  
USC Trojans 172 USC
+1.5 -110 N/A N/A -0.5 +120 + N/A N/A -1.5 +136 + -0.5 +120 + N/A N/A -2.5 -112  
Michigan Wolverines 171 Michigan
o54.5 -112 o13.5 -130 + N/A o13.5 +105 + N/A N/A o13.5 -100 + o13.5 -105 + N/A N/A o56.5 -108  
USC Trojans 172 USC
u54.5 -108 u13.5 even + N/A u13.5 -135 + N/A N/A u13.5 -124 + u13.5 -125 + N/A N/A u56.5 -112  
Michigan Wolverines 171 Michigan
+110 -110 + N/A even + N/A N/A -106 + N/A N/A N/A +110  
USC Trojans 172 USC
-130 -120 + N/A -130 + N/A N/A -120 + N/A N/A N/A -130  
Michigan Wolverines 171 Michigan
-1.5 -110 +0.5 -165 + N/A +0.5 -140 + N/A N/A +1.5 -180 + +0.5 -165 + N/A N/A +2.5 -108  
USC Trojans 172 USC
+1.5 -110 -0.5 +135 + N/A -0.5 +110 + N/A N/A -1.5 +134 + -0.5 +125 + N/A N/A -2.5 -112  
Michigan Wolverines 171 Michigan
o54.5 -112 o16 -115 + N/A o14.5 +105 + N/A N/A o14.5 +110 + o14.5 +105 + N/A N/A o56.5 -108  
USC Trojans 172 USC
u54.5 -108 u16 -115 + N/A u14.5 -135 + N/A N/A u14.5 -138 + u14.5 -135 + N/A N/A u56.5 -112  
Michigan Wolverines 171 Michigan
+110 -115 + N/A -110 + N/A N/A -111 + N/A N/A N/A +110  
USC Trojans 172 USC
-130 -115 + N/A -120 + N/A N/A -115 + N/A N/A N/A -130  

The Michigan Wolverines will take on the USC Trojans in this week's college football action. Kickoff is set for 7:30 p.m. EDT at Los Angeles Memorial Coliseum in Los Angeles, Calif. The game will be broadcast live on NBC. Here's everything you need to know about Michigan vs. USC odds, the latest college football spreads, college football over/unders and more.

For the latest trends and line movements on this matchup check out our Michigan vs. USC matchup page.

The USC Trojans opened as a -2.5 point favorite over Michigan. The total is set at over/under 57.5 total points scored by both teams combined.

This game is featured in our college football week 7 best bets article. Check out the rest of my bets for saturday.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

Updated on 10/9/25

bet365
Bet $5, Get $200 in Bonus Bets Win or Lose!
Bonus Code
VIBONUS
Claim $200
New customers only, 21+ (18+ in KY). Gambling Problem? Call 1-800-GAMBLER. Available in AZ, CO, IA, IL, IN, KS, KY, LA, MD, NC, NJ, OH, PA, TN, VA only. Bet $5 and Get $200 in Bonus Bets at bet365. Registration required. Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. T&Cs, time limits and exclusions apply.

Michigan vs. USC Best Bet

Michigan went out west for ONE game last season and underperformed mightily. They went down to Washington 27-17. I have long maintained that in the era of conference realignment, travel will play a big part in team performance. This game is no different. Michigan has played a much tougher schedule to date, but USC's offense has been humming. USC currently boasts the #1 pass offense and the 8th-best rush offense. While Michigan's defense has been stout, they have yet to face an offense as efficient as USC's.

Unless Michigan head coach Sherrone Moore decides to take the training wheels off of Bryce Underwood, this game could get out of hand very quickly.

Michigan vs. USC Best Bet: USC Trojans -2.5 (-110)


PLACE THIS BET INSTANTLY AT bet365!

(Pick from Dylan Wilkerson)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Michigan vs. USC Game?

The Wolverines will take on the Trojans at 7:30 PM ET on Saturday, October 11th.

Where is the Michigan vs. USC Game Being Played?

This game is going to be played at Los Angeles Memorial Coliseum in Los Angeles, Calif.

How Can I Watch The Michigan vs. USC Game?

You can watch Michigan vs. USC on ABC.

Can Michigan Beat The USC Trojans?

Absolutely! Michigan is a slight underdog in this game. Anything can happen in college football!

Stay updated with the latest picks, odds, and news! Tap the ★ to add us to your favorites on Google News to never miss a story.

Featured News

Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
•