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Featured Last Updated Nov 13 2025, 1:34 PM

Notre Dame vs. Pittsburgh: Prediction, Odds, Best Bet

Derek Mountain
Derek Mountain Sports Betting Expert
9 minute read
Notre Dame vs. Pittsburgh: Prediction, Odds, Best Bet

Image Credit: Michael Caterina via Imagn Images

ND @ PITT Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Notre Dame Fighting Irish 351 Notre Dame
-10 -110 -6 -120 + -6.5 -115 + -6.5 -118 + -6.5 -115 + -7.5 +106 + -7.5 +105 + -6.5 -125 -6.5 -122 + -12.5 -112  
Pittsburgh Panthers 352 Pittsburgh
+10 -110 +6 even + +6.5 -105 + +6.5 -102 + +6.5 -105 + +7.5 -130 + +7.5 -125 + +6.5 -105 +6.5 -106 + +12.5 -108  
Notre Dame Fighting Irish 351 Notre Dame
o57.5 -110 o27.5 -115 + o27.5 -110 + o27.5 -110 + o27.5 -110 + o27.5 -110 + o27.5 -105 + o27.5 -105 o27.5 -103 + o54.5 -108  
Pittsburgh Panthers 352 Pittsburgh
u57.5 -110 u27.5 -105 + u27.5 -110 + u27.5 -110 + u27.5 -110 + u27.5 -110 + u27.5 -115 + u27.5 -125 u27.5 -129 + u54.5 -112  
Notre Dame Fighting Irish 351 Notre Dame
-380 -300 + -325 + -325 + -335 + -355 + N/A N/A -305 + -455  
Pittsburgh Panthers 352 Pittsburgh
+300 +240 + +260 + +260 + +260 + +270 + N/A N/A +220 + +350  
Notre Dame Fighting Irish 351 Notre Dame
-10 -110 -3 -120 + -3.5 -110 + -3.5 -115 + -3 -125 + -3.5 -104 + -3.5 -115 + -3.5 -115 -2.5 -130 + -12.5 -112  
Pittsburgh Panthers 352 Pittsburgh
+10 -110 +3 -110 + +3.5 -118 + +3.5 -115 + +3 -105 + +3.5 -120 + +3.5 -115 + +3.5 -115 +2.5 even + +12.5 -108  
Notre Dame Fighting Irish 351 Notre Dame
o57.5 -110 o13 -110 + o12.5 -120 + o12.5 -115 + o12.5 -115 + o13.5 -104 + o13.5 -110 + o12.5 -120 o12.5 -120 + o54.5 -108  
Pittsburgh Panthers 352 Pittsburgh
u57.5 -110 u13 -120 + u12.5 -105 + u12.5 -115 + u12.5 -115 + u13.5 -120 + u13.5 -120 + u12.5 -110 u12.5 -109 + u54.5 -112  
Notre Dame Fighting Irish 351 Notre Dame
-380 -225 + -250 + -238 + -220 + -265 + N/A N/A -230 + -455  
Pittsburgh Panthers 352 Pittsburgh
+300 +175 + +190 + +180 + +180 + +200 + N/A N/A +170 + +350  
Notre Dame Fighting Irish 351 Notre Dame
-10 -110 N/A N/A -5.5 -115 + -6.5 -125 + N/A N/A N/A N/A -12.5 -112  
Pittsburgh Panthers 352 Pittsburgh
+10 -110 N/A N/A +5.5 -105 + +6.5 +105 + N/A N/A N/A N/A +12.5 -108  
Notre Dame Fighting Irish 351 Notre Dame
o57.5 -110 N/A N/A o25.5 -110 + o26.5 -115 + N/A o26.5 -115 + N/A N/A o54.5 -108  
Pittsburgh Panthers 352 Pittsburgh
u57.5 -110 N/A N/A u25.5 -110 + u26.5 -105 + N/A u26.5 -115 + N/A N/A u54.5 -112  
Notre Dame Fighting Irish 351 Notre Dame
-380 N/A N/A -278 + N/A N/A N/A N/A N/A -455  
Pittsburgh Panthers 352 Pittsburgh
+300 N/A N/A +225 + N/A N/A N/A N/A N/A +350  
Notre Dame Fighting Irish 351 Notre Dame
-10 -110 N/A N/A -2.5 -135 + N/A -4.5 -100 + -3.5 -105 + N/A N/A -12.5 -112  
Pittsburgh Panthers 352 Pittsburgh
+10 -110 N/A N/A +2.5 +105 + N/A +4.5 -132 + +3.5 -125 + N/A N/A +12.5 -108  
Notre Dame Fighting Irish 351 Notre Dame
o57.5 -110 o16 -115 + N/A o16.5 -115 + N/A o15.5 -108 + o14.5 even + N/A N/A o54.5 -108  
Pittsburgh Panthers 352 Pittsburgh
u57.5 -110 u16 -115 + N/A u16.5 -115 + N/A u15.5 -116 + u14.5 -130 + N/A N/A u54.5 -112  
Notre Dame Fighting Irish 351 Notre Dame
-380 -270 + N/A -245 + N/A -310 + N/A N/A N/A -455  
Pittsburgh Panthers 352 Pittsburgh
+300 +210 + N/A +185 + N/A +230 + N/A N/A N/A +350  
Notre Dame Fighting Irish 351 Notre Dame
-10 -110 N/A N/A -3.5 even + N/A -2.5 -130 + -3.5 -110 + N/A N/A -12.5 -112  
Pittsburgh Panthers 352 Pittsburgh
+10 -110 N/A N/A +3.5 -130 + N/A +2.5 -102 + +3.5 -120 + N/A N/A +12.5 -108  
Notre Dame Fighting Irish 351 Notre Dame
o57.5 -110 o12.5 -115 + N/A o10.5 -115 + N/A o10.5 -112 + o10.5 -125 + N/A N/A o54.5 -108  
Pittsburgh Panthers 352 Pittsburgh
u57.5 -110 u12.5 -115 + N/A u10.5 -115 + N/A u10.5 -112 + u10.5 -105 + N/A N/A u54.5 -112  
Notre Dame Fighting Irish 351 Notre Dame
-380 -240 + N/A -245 + N/A -245 + N/A N/A N/A -455  
Pittsburgh Panthers 352 Pittsburgh
+300 +190 + N/A +185 + N/A +186 + N/A N/A N/A +350  
Notre Dame Fighting Irish 351 Notre Dame
-10 -110 -0.5 -115 + N/A -2.5 -125 + N/A -2.5 -122 + -0.5 -115 + N/A N/A -12.5 -112  
Pittsburgh Panthers 352 Pittsburgh
+10 -110 +0.5 -115 + N/A +2.5 -105 + N/A +2.5 -108 + +0.5 -115 + N/A N/A +12.5 -108  
Notre Dame Fighting Irish 351 Notre Dame
o57.5 -110 o13.5 -115 + N/A o13.5 -135 + N/A o13.5 -118 + o13.5 -135 + N/A N/A o54.5 -108  
Pittsburgh Panthers 352 Pittsburgh
u57.5 -110 u13.5 -115 + N/A u13.5 +105 + N/A u13.5 -106 + u13.5 +105 + N/A N/A u54.5 -112  
Notre Dame Fighting Irish 351 Notre Dame
-380 -190 + N/A -210 + N/A -225 + N/A N/A N/A -455  
Pittsburgh Panthers 352 Pittsburgh
+300 +155 + N/A +160 + N/A +172 + N/A N/A N/A +350  

The Notre Dame Fighting Irish will take on the Pittsburgh Panthers in this week's NCAAF action. Kickoff is set for 12:00 p.m. EST at Acrisure Stadium in Pittsburgh, PA. The game will be broadcast live on ABC. Here's everything you need to know about Notre Dame vs. Pittsburgh odds, the latest NCAAF spreads, NCAAF over/unders and more.

The Notre Dame Fighting Irish opened as a -12.5 point favorite over Pittsburgh. The total is set at over/under 55.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Notre Dame vs. Pittsburgh Best Bet

A few comments from Pitt head coach Pat Narduzzi about the importance of this game had the markets selling the Panthers. Narduzzi mentioned that Notre Dame can "put 100 up on us as long as we win the next two after that," referencing that the goal is the ACC Championship.

The Irish took heavy steam after the comments despite Narduzzi also mentioning the team will "play hard" in Week 12.

Ultimately, Pitt has the ability to stop Notre Dame's ground attack.

Price and Love will use a heavy dose of outside zone against edge rushers Jimmy Scott and Isaiah Neal. Pitt has a 57% Success Rate against outside zone while creating a negative play on 17% of opponent attempts.

Notre Dame's best chance of success will come through the air. The Panthers rank 78th in Pass EPA allowed, so quarterback CJ Carr will have chances to get into scoring position against a Pitt defense that has been plundered in the red zone.

The bigger question is whether or not the Pitt offense can answer against an improved Notre Dame defense.

Explosives from Heintschel will be the key, but Notre Dame ranks 35th in Pass EPA allowed and 18th in pass breakups per game. The heavy man coverage from the Irish will provide a window of mistakes from Heintschel, who has posted a Success Rate of just 45% against the tendency.

Action Network projects Notre Dame as a 6-point favorite, as the market drifts farther in the direction of the Irish in double digits.

While there's no reason to think Pitt doesn't play this game at full effort, there are reasons for backing Carr's passing props.

Notre Dame vs. Pittsburgh Best Bet: Pitt +11.5 - CJ Carr Over 260.5 Passing Yards

(Pick from Collin Wilson)

Looking for more best bets? Check out our free college football picks and our premium subscription for the best picks!

What Time is the Notre Dame vs. Pittsburgh Game?

The Notre Dame Fighting Irish will take on the Pittsburgh Panthers at 12:00 PM EDT.

Where is the Notre Dame vs. Pittsburgh Game Being Played?

This game is going to be played at Acrisure Stadium in Pittsburgh, PA.

How Can I Watch Notre Dame vs. Pittsburgh?

You can watch Notre Dame vs. Pittsburgh on ABC.

Can Pittsburgh Beat Notre Dame?

Absolutely, check out Collin's analysis from above with respect to Pitt not only covering, but potentially pulling off the upset this Saturday.

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Derek Mountain

Derek Mountain

Derek Mountain works in the Boston area as an SEO Performance Associate for Better Collective. Derek is a recent graduate of the College of the Holy Cross in Worcester, MA where he played football for five years as well as walking on the basketball team his freshman year. Derek has experience writing and editing casino content for nearly four years. More from Derek Mountain
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