2025 College Football Odds Week 4: Lines, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

5 minute read

The College Football Odds Week 4 market has a handful of noteworthy games. Among those are an SEC battle among ranked teams and a Top 25 matchup in the Big Ten, as well.

Auburn vs. Oklahoma is arguably the most attractive contest in college football Week 4 odds. And Missouri made a big early move for its home tilt vs. South Carolina.

Here’s everything you need to know about college football odds Week 4: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 4 college football odds and action.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Kevin Jairaj/Imagn Images)

2025 College Football Odds for Week 4

Texas Tech vs. Utah Odds

• Opening point spread: Utah -4
• Opening moneyline: Utah TBA/Texas Tech TBA
• Opening total: Over/Under 58 points scored
• Time: Noon ET Saturday (FOX)

OPENING ODDS UPDATE: No. 16 Utah (3-0 SU and ATS) has three blowout wins to its credit to start the season. The Utes had no trouble Saturday at Wyoming, rolling 31-6 to narrowly cover as 24.5-point favorites.

Likewise, No. 17 Texas Tech (3-0 SU/2-1 ATS) hasn't yet been challenged. The Red Raiders flattened Oregon State 45-14 in Week 3, cashing as 24.5-point home favorites. Week 4 marks Tech's first road game of the season.

Utah opened as a 4-point favorite, with a total 57 in Circa's college football Week 4 odds. The spread is stable as of 4:45 p.m. ET Sunday, three hours after opening. But the total is already down to 55.5, with a stop at 57 along the way.

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Oregon State vs. Oregon Odds

• Opening point spread: Oregon -32
• Opening moneyline: Oregon TBA/Oregon State TBA
• Opening total: Over/Under 53.5 points scored
• Time: 3 p.m. ET Saturday (TV TBD)

OPENING ODDS UPDATE: It's a complete and total mismatch. But it's a big rivalry game, and it had a notable early move. so we'll include the Civil War.

No. 6 Oregon (3-0 SU/2-1 ATS) steps away from the Big Ten to meet its instate and former Pac-12 rival. The Ducks tuned up in Week 3 with a 34-14 win at Northwestern, but failed to cash giving 25.5 points.

Oregon State (0-3 SU and ATS) is dreadful so far, hence the massive spread on the college football Week 4 odds board. In Week 3, the Beavers lost to Texas Tech 45-14 getting 24.5 points at home.

Circa Sports opened Oregon as hefty 32-point favorites at 1:46 p.m. ET Sunday. Within two minutes, the line went straight to Ducks -35. The total jumped, as well, from 53.5 to 55 and then to 56.

Auburn vs. Oklahoma Odds

• Opening point spread: Oklahoma -6
• Opening moneyline: Oklahoma TBA/Auburn TBA
• Opening total: Over/Under 52.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 11 Oklahoma (3-0 SU/2-1 ATS) is moving up the rankings while QB John Mateer surges up the Heisman Trophy odds board. In Week 3, the Sooners dumped Temple 42-3 as 24-point road faves.

No. 22 Auburn (3-0 SU/1-2 ATS) hasn't been pressed yet this season, but also hasn't cashed in its last two games. The Tigers topped South Alabama 31-15, but couldn't cover the 26.5-point spread at home.

Oklahoma hit Circa Sports' college football Week 4 odds market at -6, with no early movement. However, the total quickly went from 52.5 to 49.5.

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Michigan vs. Nebraska Odds

• Opening point spread: Michigan -1.5
• Opening moneyline: Michigan TBA/Nebraska TBA
• Opening total: Over/Under 42.5 points scored
• Time: 3:30 p.m. ET Saturday (CBS)

OPENING ODDS UPDATE: No. 21 Michigan (2-1 SU/1-2 ATS) fell to Oklahoma 24-13 as a 4-point road 'dog in Week 2. The Wolverines got a breather in Week 3 against Central Michigan, rolling to a 63-3 victory as 27.5-point home favorites.

Nebraska (3-0 SU/2-1 ATS) has faced two consecutive cupcakes ahead of its Big Ten opener. In Week 3, the Huskers hammered FCS outfit Houston Christian 59-7 laying 49.5 points at home.

Michigan opened as 1.5-point road favorite in Circa Sports' Week 4 college football odds. That number is stable early, but the total advanced from 42.5 to 44 in short order Sunday afternoon.

South Carolina vs. Missouri Odds

• Opening point spread: Missouri -7
• Opening moneyline: Missouri TBA/South Carolina TBA
• Opening total: Over/Under 49 points scored
• Time: 7 p.m. ET Saturday (ESPN)

OPENING ODDS UPDATE: No. 23 Missouri (3-0 SU and ATS) made it to SEC play unscathed so far. In Week 3, the Tigers hammered Louisiana-Lafayette 52-10 laying 27.5 points at home.

South Carolina (2-1 SU/1-2 ATS) wasn't as fortunate. The Gamecocks closed as 3-point home favorites vs. Vanderbilt and got trucked 31-7. South Carolina tied it at 7 in the first quarter and didn't score again.

In the Gamecocks' defense, quarterback LaNorris Sellers exited late in the first half after suffering a head injury on a play that drew a targeting penalty. South Carolina was ranked No. 11 last week and is now out of the Top 25.

South Carolina vs. Missouri was a very fast mover early in Circa Sports' college football odds Week 4 market. Mizzou opened -7 and quickly got blasted to -11. And it wasn't done climbing, with the Tigers up to -13 as of 4:30 p.m. ET Sunday.

The total sped from 49 to 48, then straight to 46 within a few minutes. The number then stabilized at 46.5.

Florida vs. Miami Odds

• Opening point spread: Miami -8.5
• Opening moneyline: Miami TBA/Florida TBA
• Opening total: Over/Under 55 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

OPENING ODDS UPDATE: No. 4 Miami (3-0 SU/2-1 ATS) halted the short Cinderella run of South Florida in Week 3. The Hurricanes closed as 17.5-point favorites and breezed to a 49-12 victory.

Florida stunningly lost at home to South Florida in Week 2, then had to travel to top-10 outfit LSU in Week 3. The Gators (1-2 SU and ATS) hung around, but lost 20-10 catching 4 points.

Miami opened as an 8.5-point favorite in Circa's college football Week 4 odds, with a total of 52. The Hurricanes quickly went to -9, while the total dropped 3 points to 52.

The game went up at 1:36 p.m. ET, with no movement in the first 45 minutes on the spread or total.

Illinois vs. Indiana Odds

• Opening point spread: Indiana -5.5
• Opening moneyline: Indiana TBA/Illinois TBA
• Opening total: Over/Under 49.5 points scored
• Time: 7:30 p.m. ET Saturday (NBC)

OPENING ODDS UPDATE: No. 19 Indiana (3-0 SU/2-1 ATS) had the closest thing a team could have to a bye in Week 3. The Hoosiers faced FCS foe Indiana State and ran up the score in a 73-0 shutout as 47.5-point home favorites.

No. 9 Illinois (3-0 SU and ATS) didn't have that kind of offensive output, but still breezed in Week 3. The Fighting Illini blanked Western Michigan 38-0 laying 27.5 points at home.

Indiana opened as 5.5-point chalk in Circa Sports' college football odds Week 4. That number quickly adjusted to Hoosiers -5, then dropped to -4. The total moved from 49.5 to 51.5 right out of the gate Sunday afternoon.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson