Oklahoma vs. Michigan Prediction: Michigan Keeps it Close After Disaster

Oklahoma vs. Michigan Prediction: Michigan Keeps it Close After Disaster

Updated on 9/10/26

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The Oklahoma Sooners will take on the Michigan Wolverines in this week's college football action. Kickoff is set for 12:00 p.m. EST at Michigan Stadium in Ann Arbor, MI. The game will be broadcast live on FOX. Here's everything you need to know about Oklahoma vs. Michigan odds, the latest college football spreads, college football over/unders and more.

OU @ MICH Odds

The Oklahoma Sooners opened as a -5.5 point favorite over Michigan. The total is set at over/under 43.5 total points scored by both teams combined.

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Updated on 9/10/26

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Oklahoma vs. Michigan Prediction

Last week's Michigan vs. Western Michigan game set the college football world ablaze. Aside from a clock discrepancy, Bryce Underwood failed to take a step up from last season's performance, and the offense looked stagnant. Michigan faces a tall task this week, facing off against one of the best defenses in college football.

A bright spot for Michigan (outside of that 13-minute WMU drive) was their defense. They generated 8 tackles for loss and had an 8% generated sack rate. Michigan's defense will be strong enough to keep John Mateer and this Oklahoma offense at bay.

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Oklahoma vs. Michigan Prediction: Michigan Wolverines +6.5

(Pick from Dylan Wilkerson)

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