Oklahoma vs. Missouri: Prediction, Odds
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Missouri @ Oklahoma Betting Odds
| Time | Open | Bet365 | BetMGM | DraftKings | Caesars | FanDuel | HardRock | Fanatics | RiversCasino | Consensus | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Final | Open | | | | | | | | | | |
| | +10.5 -110 | +5 -115 | +5.5 -105 | +4.5 -112 | +4.5 -102 | +4.5 -112 | +5.5 -105 | +3.5 -110 | +4.5 -109 | +4.5 -112 | |
| | -10.5 -110 | -5 -105 | -5.5 -105 | -4.5 -108 | -4.5 -118 | -4.5 -108 | -5.5 -115 | -3.5 -120 | -4.5 -114 | -4.5 -108 | |
| Final | Open | | | | | | | | | | |
| | o42.5 -110 | o43 -110 | o42.5 -115 | o42.5 -115 | o42.5 -115 | o43.5 -115 | o42.5 -115 | o43.5 -110 | o43 -109 | o42.5 -115 | |
| | u42.5 -110 | u43 -110 | u42.5 -105 | u42.5 -105 | u42.5 -105 | u43.5 -115 | u42.5 -105 | u43.5 -120 | u43 -114 | u42.5 -105 | |
| Final | Open | | | | | | | | | | |
| | +275 | +200 | +200 | +170 | +181 | +172 | +180 | +165 | +180 | +170 | |
| | -345 | -245 | -250 | -205 | -225 | -210 | -240 | -225 | -230 | -205 | |
The Missouri Tigers will take on the Oklahoma Sooners in this week's NCAAF action. Kickoff is set for 12:00 p.m. EST at Gaylord Family Oklahoma Memorial Stadium in Norman, Okla. The game will be broadcast live on ABC. Here's everything you need to know about Missouri vs. Oklahoma odds, the latest NCAAF spreads, NCAAF over/unders and more.
The Oklahoma Sooners opened as a -7.5 point favorite over Missouri. The total is set at over/under 42.5 total points scored by both teams combined.
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Updated on 12/16/25

Oklahoma vs. Missouri Best Bet
In a battle of former Big 12 foes, Missouri will travel to Norman to take on Oklahoma, coming off its best win of the season.
This is a letdown for a Sooners' squad that was lucky to escape Tuscaloosa with a win. Oklahoma is the better team here but seven points is a lot to lay with a questionable offense at best.
On the other end, Missouri is fighting for its CFP lives. The Tigers have come up short in each of their matchups against ranked opponents, but this is their last chance to make an impression of the College Football Playoff committee. With desperation on their side, seven points are just too many. In a game with such a low total (42.5), we can expect Missouri to keep it close.
Make sure you bet this one at BetMGM Sportsbook to get the key number.
Oklahoma vs. Missouri Best Bet: Missouri +7 (-110)
(Pick from Derek Mountain)
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What Time is the Oklahoma vs. Missouri Game?
The Missouri Tigers will take on the Oklahoma Sooners at 12:00 PM ET.
Where is the Missouri vs. Oklahoma Game Being Played?
This game is going to be played at Gaylord Family Oklahoma Memorial Stadium in Norman, OK.
How Can I Watch Missouri vs. Oklahoma?
You can watch Missouri vs. Oklahoma on ABC.
Can Missouri Beat Oklahoma?
Yes, absolutely this is a huge letdown spot for the Sooners coming off an upset over the Alabama Crimson Tide.
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