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Featured Last Updated Sep 25 2025, 1:00 PM

Penn State vs. Oregon: Prediction, Odds, Best Bet

Dylan Wilkerson
Dylan Wilkerson Sports Betting Expert
9 minute read
Penn State vs. Oregon: Prediction, Odds, Best Bet

Image Credit: Matthew O'Haren-Imagn Images

ORE @ PSU Odds

  • Full Game
  • 1H
  • 1Q
  • 2Q
  • 3Q
  • 4Q
  • Spread
  • Total
  • Moneyline
Oregon Ducks 195 Oregon
+3.5 -110 +2.5 -105 + +2.5 -105 + +2.5 -108 + +2.5 -105 + +2.5 -110 + +2.5 -108 + +2.5 -105 +2.5 -113 + +2.5 -112 +3.5 -112  
Penn State Nittany Lions 196 Penn State
-3.5 -110 -2.5 -115 + -2.5 -115 + -2.5 -112 + -2.5 -115 + -2.5 -120 + -2.5 -112 + -2.5 -115 -2.5 -110 + -2.5 -112 -3.5 -108  
Oregon Ducks 195 Oregon
o52.5 -110 o25.5 -105 + N/A o24.5 -108 + o25.5 -105 + N/A o26.5 +106 + o24.5 -105 o24.5 -115 + o25.5 -120 o52.5 -105  
Penn State Nittany Lions 196 Penn State
u52.5 -110 u25.5 -115 + N/A u24.5 -112 + u25.5 -115 + N/A u26.5 -130 + u24.5 -115 u24.5 -113 + u25.5 -108 u52.5 -115  
Oregon Ducks 195 Oregon
+154 +125 + N/A +130 + +130 + +125 + +126 + N/A +118 + +118 +145  
Penn State Nittany Lions 196 Penn State
-185 -150 + N/A -155 + -155 + -160 + -154 + N/A -155 + -155 -175  
Oregon Ducks 195 Oregon
+3.5 -110 +0.5 -130 + +0.5 -125 + +0.5 -120 + +0.5 -130 + N/A +1.5 -145 + -0.5 +165 +1.5 -148 + +1.5 -148 +3.5 -112  
Penn State Nittany Lions 196 Penn State
-3.5 -110 -0.5 even + -0.5 even + -0.5 even + -0.5 even + N/A -1.5 +116 + +0.5 -235 -1.5 +115 + -1.5 +114 -3.5 -108  
Oregon Ducks 195 Oregon
o52.5 -110 o10.5 -115 + N/A o10.5 -102 + o10.5 -105 + N/A o10.5 +106 + o10.5 -110 o10.5 +104 + o10.5 -103 o52.5 -105  
Penn State Nittany Lions 196 Penn State
u52.5 -110 u10.5 -115 + N/A u10.5 -118 + u10.5 -125 + N/A u10.5 -132 + u10.5 -120 u10.5 -134 + u10.5 -127 u52.5 -115  
Oregon Ducks 195 Oregon
+154 +110 + N/A +114 + +110 + N/A +120 + N/A +107 + +108 +145  
Penn State Nittany Lions 196 Penn State
-185 -140 + N/A -135 + -140 + N/A -154 + N/A -139 + -139 -175  
Oregon Ducks 195 Oregon
+3.5 -110 N/A N/A +1.5 -118 + +0.5 -105 + N/A N/A N/A N/A N/A +3.5 -112  
Penn State Nittany Lions 196 Penn State
-3.5 -110 N/A N/A -1.5 -102 + -0.5 -115 + N/A N/A N/A N/A N/A -3.5 -108  
Oregon Ducks 195 Oregon
o52.5 -110 N/A N/A o26.5 -110 + o25.5 -110 + N/A N/A N/A N/A N/A o52.5 -105  
Penn State Nittany Lions 196 Penn State
u52.5 -110 N/A N/A u26.5 -110 + u25.5 -110 + N/A N/A N/A N/A N/A u52.5 -115  
Oregon Ducks 195 Oregon
+154 N/A N/A +120 + N/A N/A N/A N/A N/A N/A +145  
Penn State Nittany Lions 196 Penn State
-185 N/A N/A -142 + N/A N/A N/A N/A N/A N/A -175  
Oregon Ducks 195 Oregon
+3.5 -110 N/A N/A +0.5 -120 + N/A N/A +1.5 -136 + N/A N/A N/A +3.5 -112  
Penn State Nittany Lions 196 Penn State
-3.5 -110 N/A N/A -0.5 -110 + N/A N/A -1.5 +102 + N/A N/A N/A -3.5 -108  
Oregon Ducks 195 Oregon
o52.5 -110 o14 -115 + N/A o13.5 -110 + N/A N/A o14.5 +112 + N/A N/A N/A o52.5 -105  
Penn State Nittany Lions 196 Penn State
u52.5 -110 u14 -115 + N/A u13.5 -120 + N/A N/A u14.5 -140 + N/A N/A N/A u52.5 -115  
Oregon Ducks 195 Oregon
+154 +115 + N/A +114 + N/A N/A +114 + N/A N/A N/A +145  
Penn State Nittany Lions 196 Penn State
-185 -145 + N/A -145 + N/A N/A -146 + N/A N/A N/A -175  
Oregon Ducks 195 Oregon
+3.5 -110 N/A N/A +0.5 -140 + N/A N/A +1.5 -154 + N/A N/A N/A +3.5 -112  
Penn State Nittany Lions 196 Penn State
-3.5 -110 N/A N/A -0.5 +110 + N/A N/A -1.5 +118 + N/A N/A N/A -3.5 -108  
Oregon Ducks 195 Oregon
o52.5 -110 o13 -115 + N/A o12.5 -115 + N/A N/A o10.5 -108 + N/A N/A N/A o52.5 -105  
Penn State Nittany Lions 196 Penn State
u52.5 -110 u13 -115 + N/A u12.5 -115 + N/A N/A u10.5 -116 + N/A N/A N/A u52.5 -115  
Oregon Ducks 195 Oregon
+154 +105 + N/A +114 + N/A N/A +112 + N/A N/A N/A +145  
Penn State Nittany Lions 196 Penn State
-185 -135 + N/A -145 + N/A N/A -142 + N/A N/A N/A -175  
Oregon Ducks 195 Oregon
+3.5 -110 +0.5 -155 + N/A +0.5 -135 + N/A N/A +1.5 -160 + N/A N/A N/A +3.5 -112  
Penn State Nittany Lions 196 Penn State
-3.5 -110 -0.5 +125 + N/A -0.5 +105 + N/A N/A -1.5 +120 + N/A N/A N/A -3.5 -108  
Oregon Ducks 195 Oregon
o52.5 -110 o14 -115 + N/A o14.5 +110 + N/A N/A o13.5 -120 + N/A N/A N/A o52.5 -105  
Penn State Nittany Lions 196 Penn State
u52.5 -110 u14 -115 + N/A u14.5 -140 + N/A N/A u13.5 -104 + N/A N/A N/A u52.5 -115  
Oregon Ducks 195 Oregon
+154 even + N/A even + N/A N/A +104 + N/A N/A N/A +145  
Penn State Nittany Lions 196 Penn State
-185 -130 + N/A -130 + N/A N/A -132 + N/A N/A N/A -175  

The Oregon Ducks will take on the Penn State Nittany Lions in this week's college football action. Kickoff is set for 7:30 p.m. EDT at West Shore Home Field at Beaver Stadium in University Park, Pa. The game will be broadcast live on NBC. Here's everything you need to know about Oregon vs. Penn State odds, the latest college football spreads, college football over/unders and more.

The Penn State opened as a -3.5 point favorite over Oregon. The total is set at over/under 52.5 total points scored by both teams combined.

Be sure to check out the latest college football odds and stay up to date on the latest sportsbook promos, including the bet365 bonus code!

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Penn State vs. Oregon Best Bet

I don't love the cross-country road trip for Oregon or the fact that Penn State is off an FCS/bye week combo, but I can't get to this number, with Penn State on the other side of 3. It's still a bit difficult to gauge exactly what Dante Moore is going to be for the Ducks, but he has been fantastic so far this year, completing 75% of his passes with an 11-1 TD/INT ratio. He also grades out as PFF's 6th-best QB with a minimum of 95 dropbacks, with 7 big-time throws and just 1 turnover-worthy play. The same can not be said of Drew Allar, who is PFF's 60th-rated QB with only 1 big-time throw and 2 turnover-worthy plays in fewer games against worse competition. I believe in the talent Penn State has at a lot of positions, but I don't think they'll be able to effectively throw the ball against the Ducks.

Allar has struggled mightily against top-tier competition in his career. Just last year, with Andy Kotelnicki as OC, he had the following stat lines:

Against Ohio State: 12/20, 146 yards, 0 TD, 1 INT

Against Oregon: (neutral site): 20/39, 226 yards, 3 TDs, 2 INT. Decent, but they still lost by 8.

Against SMU: 13/22, 127 yards, 0 TDs, 0 INT

Against Notre Dame: 12/23, 135 yards, 0 TD, 1 INT

In a big game like this, QBs have to step up, and I just don't have faith in Allar to do it against a top-5 defense. I also do not trust James Franklin to win against another elite program. And for those reasons, I am out. Ducks outright.

Penn State vs. Oregon Best Bet: Oregon Ducks +3.5 (-110)


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(Pick from Jourdan Case)

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What Time is the Penn State vs. Oregon Game?

The Nittany Lions will take on the Ducks at 7:30 PM ET on Saturday, September 27th.

Where is the Penn State vs. Oregon Game Being Played?

This game is going to be played at West Shore Home Field at Beaver Stadium in University Park, Pa.

How Can I Watch The Penn State vs. Oregon Game?

You can watch Penn State vs. Oregon on NBC.

Can Penn State Beat Oregon?

Absolutely! Penn State is actually a favorite, so oddsmakers think Penn State is going to win this game.

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Dylan Wilkerson

Dylan Wilkerson

Dylan Wilkerson has over 2 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson
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