2022 Purdue Boilermakers Betting Odds, Picks & Predictions


The Boilermakers head into the 2022 season with sky-high anticipation after exceeding expectations by a mile in 2021. Head coach Jeff Brohm has turned the Boilermakers into a tough out, similar to the days when Joe Tiller was running the show in West Lafayette.

Purdue ended up winning eight games in the regular season, including victories on the road against Iowa and Nebraska, as well as an impressive home win over Michigan State. The Boilermakers showed how far they are from competing with the big boys, losing by double digits against Notre Dame, Ohio State and Wisconsin, but Purdue did win a wild and impressive game against Tennessee in the Music City Bowl in Nashville, the backyard of the Vols.

QB Aidan O'Connell passed for 534 yards and five touchdowns in the bowl win, carrying over the momentum from the regular season when he completed 73.5% of his passes for 3,178 yards, 23 touchdowns and eight interceptions. He is a pure pocket passer and will never be confused with a dual threat.

Unfortunately for O'Connell, he lost WR David Bell to the NFL, and he'll now be cashing checks and catching balls in Cleveland. Top-flight DL George Karlaftis is also off to the NFL, now in Kansas City.

The cupboard isn't exactly bare for Purdue, however, as WR Tyrone Tracy arrives from Iowa via the transfer portal to join WR Broc Thompson. The latter rolled up 217 receiving yards and two scores in the Music City Bowl, picking up the slack for the academically-ineligible WR Milton Wright. The senior wideout missed the bowl due to academic issues, and he has been ruled out for the 2022 season, too.

Updated on 09/26/2023
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WRs Mershawn Rice and T.J. Sheffield will be thrust into much bigger roles. If the wideouts struggle, the tight end position has a rather full room. TE Payne Durham (45-467-6) is the top option, but TEs Garrett Miller and Paul Piferi each could also see more responsibilities.

On defense, the team saw defensive coordinator Brad Lambert leave to take the job at Wake Forest, so now Ron English and Mark Hagen will share the role as co-coordinators. The secondary is above-average, led by S Cam Allen. CB Reese Taylor transfers from Indiana, the other side of the Old Oaken Bucket rivalry, to bolster the defensive backfield.

The schedule starts off tough with a home game against Penn State, doubling as the conference opener. At least the game is at Ross-Ade, but it will be a very good game which could go either way. The non-conference schedule isn't terribly tough, with a trip to Syracuse as the biggest hurdle. In the crossover portion of the schedule, Purdue avoids Michigan, Michigan State and Ohio State, and the toughest conference trips are to Minnesota and Wisconsin. This team has the potential to win eight or nine games if Brohm gets solid production from the new wideouts, and at plus-money it's a tremendous value.

Best Bet: Purdue OVER 7.5 Wins (+115)


  • Thu., Sept. 1 - vs. Penn State
  • Sat., Sept. 10 - vs. Indiana State
  • Sat., Sept. 17 - at Syracuse
  • Sat., Sept. 24 - vs. FAU
  • Sat., Oct. 1 - at Minnesota
  • Sat., Oct. 8 - at Maryland
  • Sat., Oct. 15 - vs. Nebraska
  • Sat., Oct. 22 - at Wisconsin
  • Sat., Nov. 5 - vs. Iowa
  • Sat., Nov. 12 - at Illinois
  • Sat., Nov. 19 - vs. Northwestern
  • Sat., Nov. 26 - at Indiana


  • Over 7.5 (+105)
  • Under 7.5 (-125)



Anything is possible in the Big Ten West, where Wisconsin is the slight favorite, with Iowa, Minnesota, Nebraska and Purdue all jockeying for position behind the Badgers. And Wisconsin is anything but a dominant favorite. In other words, the West is wide open. But, this prop isn't if it is possible just to make the Big Ten Championship Game, but this prop is whether Purdue will win it. The answer is no. The East has Michigan, Michigan State, Ohio State and Penn State, and neither of those teams would lose to any member of the West. Avoid the Boilermakers, and anyone from the West Division.



Purdue is on an upward trajectory, but this is a team which has still lost at least four games in each of the past 41 seasons since going 9-3 in 1980. This isn't a national championship caliber team, and as impressive as O'Connell can be, this isn't a team which will be headed to the CFP anytime soon.

QB Aidan O'Connell looks to build upon his strong 2021 season. (Getty Images)


Aidan O'Connell (QB) +10000

O'Connell has the potential to put up some big-time numbers, but losing Bell to the NFL, and Milton to bad academics will hurt. The experienced signal caller will have to develop rapport with a new set of receivers in a hurry. Thompson looked like he has some nice potential in the bowl game, but O'Connell isn't likely to distance himself from some of the other known quantities, and he'll also be on a team eating plenty of losses, which doesn't help.


  • SU: 9-4
  • ATS: 8-5
  • O/U: 5-8
  • ATS-Home: 4-3
  • ATS-Road: 4-2
  • ATS-Favorite: 4-2
  • ATS-Underdog: 4-3