Purdue Boilermakers Odds
| Date | Opp | Close | Result | ATS/OU |
| Aug 30, 2025 | Ball State | -16.5
/ 48.5 | Won 31-0 | Won /
Under |
| Sep 6, 2025 | Southern Illinois | -20.5
/ 52 | Won 34-17 | Lost /
Under |
| Sep 13, 2025 | USC | +20.5
/ 59.5 | Lost 17-33 | Won /
Under |
| Sep 20, 2025 | @Notre Dame | +24.5
/ 51 | Lost 30-56 | Lost /
Over |
| Oct 4, 2025 | Illinois | +7
/ 54.5 | Lost 27-43 | Lost /
Over |
| Oct 11, 2025 | @Minnesota | +7
/ 49.5 | Lost 20-27 | Push /
Under |
| Oct 18, 2025 | @Northwestern | +3
/ 47.5 | Lost 0-19 | Lost /
Under |
| Oct 25, 2025 | Rutgers | -2.5
/ 60.5 | Lost 24-27 | Lost /
Under |
| Nov 1, 2025 | @Michigan | +21
/ 48.5 | Lost 16-21 | Won /
Under |
| Nov 8, 2025 | Ohio State | +29.5
/ 50.5 | Lost 10-34 | Won /
Under |
| Nov 15, 2025 | @Washington | +14.5
/ 50.5 | Lost 13-49 | Lost /
Over |
| Nov 28, 2025 | Indiana | +28.5
/ 54.5 | Lost 3-56 | Lost /
Over |
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