UCLA vs. Oregon Prediction: UCLA Ends Oregon’s Playoff Hopes in Classic Big Ten Matchup

Dylan Wilkerson Sports Betting Expert

14 minute read

The UCLA Bruins will take on the Oregon Ducks in this week's college football action. Kickoff is set for 3:30 p.m. EST at Autzen Stadium in Eugene, OR. The game will be broadcast live on CBS. Here's everything you need to know about UCLA vs. Oregon odds, the latest college football spreads, college football over/unders and more.

UCLA @ Oregon Betting Odds

• Spread
• Total
• Moneyline

Time	Open	Bet365	BetMGM	DraftKings	Caesars	FanDuel	Fanatics	RiversCasino	Consensus
	Open	›	›	›	›	›	›	›
391 UCLA	+12.5 -110	+11.5 -111	+11.5 -110	+11.5 -110	+11.5 -113	+11.5 -110	+11.5 -110	+12 -112	+11.5 -110
392 Oregon	-12.5 -110	-11.5 -109	-11.5 -108	-11.5 -110	-11.5 -107	-11.5 -110	-11.5 -110	-12 -112	-11.5 -110
Matchup
	Open	›	›	›	›	›	›	›
391 UCLA	o60.5 -110	o58.5 -112	o58.5 -110	o58.5 -115	o59 -110	o58.5 -110	o59 -110	o59 -109	o58.5 -115
392 Oregon	u60.5 -110	u58.5 -108	u58.5 -108	u58.5 -105	u59 -110	u58.5 -110	u59 -110	u59 -114	u58.5 -105
Matchup
	Open	›	›	›	›	›	›	›
391 UCLA	+400	+355	+360	+350	+340	+320	+360	+350	+350
392 Oregon	-535	-460	-450	-455	-440	-420	-475	-480	-455
Matchup

The Oregon Ducks opened as a -11 point favorite over UCLA. The total is set at over/under 58.5 total points scored by both teams combined.

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Updated on 10/7/26

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UCLA vs. Oregon Prediction

This game is going to be a lot closer than what people think. UCLA's net adjusted EPA/play ranks 14th in college football, which is 4 spots better than Oregon's 18th ranking for that same metric.

The weakest unit in this matchup is going to be Oregon's defense. They rank 101st against the rush, 129th in early-down EPA allowed, and 123rd in average 3rd-down distance allowed.

UCLA should be able to set their offense up for success with Wayne Knight and the run game. This should open up the offense for UCLA and allow them to control the game.

Updated on 10/7/26

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UCLA vs. Oregon Prediction: UCLA Bruins Moneyline (+360)

(Pick from Dylan Wilkerson)

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Dylan Wilkerson

Dylan Wilkerson has over 5 years of experience reporting and analyzing the sports betting industry for various sites. His portfolio includes work for SportsHandle and Action Network, in addition to VegasInsider. His favorite sports are the NFL, College Football, The PGA Tour, the LIV Tour, and Cricket. Dylan has a broad and deep understanding of various sports-related topics. More from Dylan Wilkerson