NFL Week 16 Odds: Lines, Spreads, Betting Trends for Every Game

Patrick Everson Sports Betting Expert

12 minute read

2025 NFL Week 16 Odds

NFL Week 16 odds are full of games with playoff implications, as postseason positioning continues to shake out.

And the best clash on the Week 16 NFL odds board is the first: Los Angeles Rams vs. Seattle Seahawks, with those teams sitting 1-2 in Super Bowl odds. Also on tap: Green Bay Packers vs. Chicago Bears.

Here’s everything you need to know about NFL odds Week 16: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 16 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Gregory Fisher/Imagn Images)

Los Angeles Rams vs. Seattle Seahawks Odds

• Opening point spread: Pick
• Opening moneyline: Seahawks TBA/Rams TBA
• Opening total: Over/Under 46.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

OPENING ODDS UPDATE: Seattle (11-3 SU/10-4 ATS) almost became an immediate victim of Old Man Rivers, narrowly surviving an upset bid in Week 15. The Seahawks needed a 56-yard field goal with 18 seconds remaining to beat Philip Rivers and Indianapolis 18-16.

All of Seattle's points came from the leg of Jason Myers, who made six field goals on the day. The Seahawks fell miles short of cashing as 13-point home favorites, but are still 8-1 SU/7-2 ATS in their last nine games.

Los Angeles is also 11-3 SU/10-4 ATS after holding off the Detroit Lions 41-34 as 6-point home favorites in Week 15. And like the Seahawks, the Rams are 8-1 SU/7-2 ATS in their last nine.

In Week 11 at L.A., the Rams beat the Seahawks 21-19, but Seattle covered as a 3-point pup.

The SuperBook rates this game a toss-up in NFL Week 16 odds.

"We opened it pick, and I don’t see any reason to move for now," SuperBook vice president John Murray said Sunday night. "It looked as if Seattle almost got caught looking ahead to this game today vs. the Colts. But the Seahawks pulled it out in the end.

"The No. 1 seed in the NFC is on the line. We’ll probably be rooting for the Seahawks."

Philadelphia Eagles vs. Washington Commanders Odds

• Opening point spread: Eagles -5.5
• Opening moneyline: Eagles TBA/Commanders TBA
• Opening total: Over/Under 45 points scored
• Time: 5 p.m. ET Saturday (FOX)

OPENING ODDS UPDATE: Philadelphia (9-5 SU/8-6 ATS) found the cure for a three-game losing streak: Playing the Las Vegas Raiders. In Week 15, the Eagles breezed to a 31-0 victory laying 12.5 points at home.

Washington (4-9 SU and ATS) halted a season-killing eight game losing streak in Week 14. The Commanders closed as 2.5-point underdogs at the Giants and notched a 29-21 victory.

Philly and Washington met in last season's NFC Championship Game, with the Eagles rumbling to a 55-23 win. Week 16 marks the first meeting of the season for these two, who play again at Washington in Week 18.

Eagles-Commanders opened at Philadelphia -5.5 in The SuperBook's Week 16 NFL odds, and the line went to -6 within an hour Sunday night.

"Philadelphia should be a big public play to start next weekend, with the books needing the Commanders," SuperBook VP John Murray said.

Green Bay Packers vs. Chicago Bears Odds

• Opening point spread: Packers -3
• Opening moneyline: Packers TBA/Bears TBA
• Opening total: Over/Under 46.5 points scored
• Time: 8:20 p.m. ET Saturday (FOX)

OPENING ODDS UPDATE: Green Bay (9-4-1 SU/6-8 ATS) had its four-game win streak halted in Week 15. The Packers led at Denver 23-14 early in the third quarter, but couldn't hold up in a costly 34-26 setback giving 1.5 points.

Green Bay fell behind Chicago in the NFC North. Further, defensive star Micah Parsons reportedly tore an ACL, which would his season. And standout wideout Christian Watson left in the third quarter with a chest injury.

Chicago (10-4 SU/8-5-1 ATS) rebounded nicely from its Week 14 loss at Green Bay. In extremely cold temperatures, the Bears bashed Cleveland 31-3 as 7.5-point home favorites.

The Bears and Packers just met in Week 14, with Green Bay winning 28-21 as 6.5-point home chalk. This time around, The SuperBook opened the Pack -3, quickly went to -2.5 Sunday night, then settled at -2.

"It's a rematch from the game played just 13 days earlier. I think we’ll end up needing the Bears this time," SuperBook VP John Murray said.

Los Angeles Chargers vs. Dallas Cowboys Odds

• Opening point spread: Cowboys -1.5
• Opening moneyline: Cowboys TBA/Chargers TBA
• Opening total: Over/Under 49 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Dallas (6-6-1 SU/7-6 ATS) is hanging by a thread to make the playoffs. The Cowboys are right now in the midst of their Week 15 assignment, hosting Minnesota on Sunday Night Football.

Los Angeles (10-4 SU/8-6 ATS) has won and cashed three in a row and is 6-1 SU in its last seven games. In Week 15, the Chargers ended Kansas City's playoff hopes, winning 16-13 as 6-point road underdogs.

Chargers-Cowboys opened at Dallas -1.5 in The SuperBook's NFL odds Week 16 market., but came off the board once Vikings-Cowboys kicked off. Chargers-Cowboys will go back up Monday morning.

Tampa Bay Buccaneers vs. Carolina Panthers Odds

• Opening point spread: Buccaneers -2
• Opening moneyline: Buccaneers TBA/Panthers TBA
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Carolina (7-7 SU/8-6 ATS) blew an opportunity to gain the upper hand in the NFC South. The Panthers went to New Orleans as 2.5-point favorites and exited with a 20-17 loss on a final-seconds Saints field goal.

Tampa Bay (7-7 SU/5-9 ATS) has almost completely blown up what was once a promising season. The Bucs were 6-2 SU through eight weeks, but have gone 1-5 SU/0-6 ATS since then, including three outright losses as a favorite.

In the Week 15 Thursday nighter, the Bucs were laying 6 points at home vs. Atlanta and imploded in a 29-28 loss. Tampa blew a 14-point fourth-quarter lead, giving up the final 15 points – two touchdowns, while stopping both 2-point conversion attempts – and a final-seconds field goal.

The SuperBook opened Tampa Bay -2 in NFL Week 16 odds and went to -2.5 Sunday evening.

Buffalo Bills vs. Cleveland Browns Odds

• Opening point spread: Bills -10
• Opening moneyline: Bills TBA/Browns TBA
• Opening total: Over/Under 41.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Buffalo (10-4 SU/7-7 ATS) isn't letting New England waltz away with the AFC East title. The Bills dug themselves into a 21-0 Week 15 hole at Foxboro, but rallied for a 35-31 victory giving 2.5 points to end the Patriots' 10-game win streak.

Cleveland (3-11 SU/5-9 ATS) managed only a third-quarter field goal behind Shedeur Sanders in frigid Chicago. The Browns were 7.5-point 'dogs and got blown out 31-3.

Bills-Browns opened at Buffalo -10 in The SuperBook's Week 16 NFL odds, with no early movement on the spread. But the total climbed from 41.5 to 42, then to 43 Sunday night.

Kansas City Chiefs vs. Tennessee Titans Odds

• Opening point spread: Chiefs -4.5
• Opening moneyline: Chiefs TBA/Titans TBA
• Opening total: Over/Under 38.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Kansas City (6-8 SU/5-9 ATS) reached the last seven AFC title games, winning five conference titles and three Super Bowls. But the Chiefs will miss the playoffs this season. Worse still, Patrick Mahomes suffered a season-ending ACL tear.

K.C. sealed its fate with a 16-13 loss giving 6 points at home against the L.A. Chargers in Week 15. Mahomes was injured late in the fourth quarter. The Chiefs are 1-5 SU/0-6 ATS in their last six games.

Tennessee (2-12 SU/6-8 ATS) hung around in the first half at San Francisco. But the Titans couldn't keep pace in the second half, losing 37-24 as 12.5-point underdogs.

Last week's lookahead line on Chiefs-Titans was Kansas City -10.5. With no Mahomes, The SuperBook opened K.C. -4.5 and moved to -4 Sunday night, and the total dipped from 38.5 to 37.5.

Cincinnati Bengals vs. Miami Dolphins Odds

• Opening point spread: Dolphins -1.5
• Opening moneyline: Dolphins TBA/Bengals TBA
• Opening total: Over/Under 50.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Cincinnati (4-10 SU/6-8 ATS) showed a little life when Joe Burrow returned, beating Baltimore and nearly beating Buffalo, both on the road. But in Week 15, the Bengals had no answer for the Ravens, losing 24-0 as 3-point home pups.

Miami (6-7 SU/7-6 ATS) isn't yet out of Week 15. The Dolphins, on a four-game SU run, visit Pittsburgh on Monday night.

Miami opened -1.5 vs. Cincy in The SuperBook's NFL odds Week 16 market, with no movement Sunday night.

Minnesota Vikings vs. New York Giants Odds

• Opening point spread: Vikings -2.5
• Opening moneyline: Vikings TBA/Giants TBA
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: New York (2-12 SU/7-7 ATS) saw its losing streak stretch to eight games in Week 15. The Giants closed as 2.5-point home favorites vs. Washington and lost 29-21.

Minnesota (5-8 SU and ATS) has been a big letdown after going 14-3 SU/11-5-1 ATS in the 2024-25 regular season. The Vikes are in the midst of their Week 15 contest at Dallas in the Sunday night game.

Vikings-Giants opened at Minnesota -2.5 in The SuperBook's NFL Week 16 odds, then came off the board once Vikes-Cowboys kicked off. Vikes-Giants will go back up Monday morning.

New York Jets vs. New Orleans Saints Odds

• Opening point spread: Saints -3.5
• Opening moneyline: Saints TBA/Jets TBA
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: New Orleans (4-10 SU/6-8 ATS) notched a modest home upset in Week 15, further mucking up the latest edition of Who Wants To Win The NFC South. The Saints, 2.5-point home 'dogs, overcame a 17-7 third-quarter deficit to beat Carolina 20-17 on a final-seconds field goal.

New York (3-11 SU/5-9 ATS) was a 13.5-point underdog at Jacksonville in Week 15, and the game went accordingly. The Jets got flattened 48-20, their fourth loss in the last five games.

The SuperBook opened Jets-Saints at New Orleans -3.5 and moved to -4 within an hour Sunday night.

Jacksonville Jaguars vs. Denver Broncos Odds

• Opening point spread: Broncos -3
• Opening moneyline: Broncos TBA/Jaguars TBA
• Opening total: Over/Under 43.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Denver (12-2 SU/6-8 ATS) looked to be in a trouble in the third quarter, down 23-14 and with Green Bay seemingly in control. But the Broncos rallied once again, claiming a 34-26 victory as 1.5-point home pups.

Jacksonville (10-4 SU and ATS) is on a five-game SU and ATS upswing that has it atop the AFC South. In Week 15, the Jaguars thumped the New York Jets 48-20 laying 13.5 points at home.

The Broncos opened as 3-point favorites vs. the Jags in The SuperBook's Week 16 NFL odds. There was no change in the number Sunday night, but Denver briefly adjusted to -3 (-120), then returned to -3 flat.

"This game has way more playoff implications than we thought it would back in the summer," SuperBook vice president John Murray said. "We took some money on Jaguars +3, but nothing that has prompted us to move the line."

The total was on the move, going from 43.5 to 44 in short order, then on to 45.

Atlanta Falcons vs. Arizona Cardinals Odds

• Opening point spread: Falcons -1.5
• Opening moneyline: Falcons TBA/Cardinals TBA
• Opening total: Over/Under 45.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

OPENING ODDS UPDATE: Arizona (3-11 SU/6-8 ATS) has lost six in a row and 11 of its last 12 (5-7 ATS). In Week 15, the Cardinals got rolled at Houston 40-20 as 10-point underdogs.

Atlanta (6-9 SU and ATS) halted a 1-7 SU and ATS nosedive in the Week 15 Thursday night game, and in comeback upset fashion, no less. The Falcons erased a 28-14 fourth-quarter deficit at Tampa Bay, rallying for two TDs and a game-ending field goal to win 29-28 catching 6 points.

Falcons-Cards opened at Atlanta -1.5, with no early movement at The SuperBook.

Pittsburgh Steelers vs. Detroit Lions Odds

• Opening point spread: Lions -6.5
• Opening moneyline: Lions TBA/Steelers TBA
• Opening total: Over/Under 50.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Detroit (8-6 SU/7-7 ATS) is now on the outside looking in for the NFC playoffs, after being among the preseason/early-season Super Bowl favorites. In Week 15, the Lions lost a shootout with the L.A. Rams 41-34 catching 6.5 points on the road.

Pittsburgh (7-6 SU/7-5-1 ATS) hopes to keep a leg up on Baltimore in the AFC North. The Steelers first need to get out of Week 15, as they host Miami on Monday night.

Detroit opened as 6.5-point home chalk vs. Pittsburgh in The SuperBook's NFL Week 16 odds. There was no movement Sunday night.

"It’s been all Lions so far, with bets on Detroit at -6 on the lookahead line and -6.5. It looks like we’ll be Steelers fans," SuperBook VP John Murray said.

Las Vegas Raiders vs. Houston Texans Odds

• Opening point spread: Texans -14
• Opening moneyline: Texans TBA/Raiders TBA
• Opening total: Over/Under 37.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

OPENING ODDS UPDATE: Houston (9-5 SU and ATS) is on a well-timed six-game winning streak (5-1 ATS). In Week 15, the Texans easily dispatched Arizona 40-20 giving 10 points at home.

Las Vegas (2-12 SU/5-9 ATS) put a doughnut on the scoreboard while losing its eighth straight game. The Raiders fell at Philly 31-0 catching 12.5 points.

The SuperBook opened Houston as 14-point home chalk vs. Las Vegas, with no movement Sunday night. However, there was a little early toggling on the total, which went from 37.5 to 37, then returned to 37.5.

New England Patriots vs. Baltimore Ravens Odds

• Opening point spread: Ravens -2.5
• Opening moneyline: Ravens TBA/Patriots TBA
• Opening total: Over/Under 47.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

OPENING ODDS UPDATE: New England (11-3 SU/9-5 ATS) saw its 10-game win streak come to an end in Week 15. The Patriots jumped out to a 21-0 lead vs. Buffalo and was still up 24-7 at halftime. But the Pats then allowed a big comeback and lost 35-31 as 2.5-point home favorites.

Baltimore (7-7 SU/6-8 ATS) halted a two-game hiccup to stay in the hunt for the AFC North title. The Ravens, who two weeks ago lost at home to Cincinnati, avenged that setback with a 24-0 blanking as 3-point road favorites.

Baltimore opened -2.5 vs. New England in The SuperBook's Week 15 NFL odds. The Ravens briefly adjusted to -2.5 (-120) Sunday night, then returned to -2.5 flat.

"It says a lot about the Patriots' power rating that they are only getting 2.5 points in Baltimore on Sunday Night Football. Not much to report action-wise yet. I would expect good two-way," SuperBook vice president John Murray said.

San Francisco 49ers vs. Indianapolis Colts Odds

• Opening point spread: 49ers -5.5
• Opening moneyline: 49ers TBA/Colts TBA
• Opening total: Over/Under 46.5 points scored
• Time: 8:15 p.m. ET Monday (ESPN/ABC)

OPENING ODDS UPDATE: Indianapolis (8-6 SU and ATS) nearly pulled off a huge upset behind just-acquired QB Philip Rivers. The Colts closed as 13-point underdogs at Seattle and led most of the game, but lost 18-16 on a field goal with 18 seconds remaining.

San Francisco (10-4 SU and ATS) has won and covered its last four, though the latest spread-cover was just barely. The Niners topped Tennessee 37-34, cashing as 12.5-point home favorites on a field goal with 1:10 remaining.

San Fran opened -5.5 vs. Indy at The SuperBook, with no movement Sunday night.

"It'll be interesting to see who is under center for Indianapolis next Monday Night. We’ll be Colts fans," SuperBook VP John Murray said.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson