NFL Week 16 Odds: 49ers vs. Colts; Lines, Spreads, Betting Trends for Every Game

Patrick Everson Sports Betting Expert

27 minute read

2025 NFL Week 16 Odds

NFL Week 16 odds are full of games with playoff implications, as postseason positioning continues to shake out.

All that remains in Week 16 NFL odds is the Monday night matchup: San Francisco 49ers vs. Indianapolis Colts.

Here’s everything you need to know about NFL odds Week 16: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on NFL Week 16 odds and action. Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Joe Rondone/Imagn Images)

2025 NFL Odds for Week 16

San Francisco 49ers vs. Indianapolis Colts Odds

• Opening point spread: 49ers -5.5
• Opening moneyline: 49ers -250/Colts +210
• Opening total: Over/Under 46.5 points scored
• Time: 8:15 p.m. ET Monday (ESPN/ABC)

GAME DAY UPDATE: This line has bounced around a lot during the week and now sits at 49ers -4.5 (-105) in BetMGM's Week 16 NFL odds. Eight days ago, San Fran opened -5.5, then peaked at -6.5 on Tuesday and Wednesday.

On Friday, the Niners backed up to -5.5 (-118), and today brought a few more drops, to -5/-4.5/-3.5 (-118).

"We have two-way action on the spread. But the majority of moneyline money is on the 49ers. We'd be happy with a Colts win," BetMGM trading manager Tristan Davis said.

The total bounced between 46/46.5 much of the week, then this afternoon went to 45.5 for literally a minute. It's now 46.5, and Davis said the book needs the Under, per usual.

MIDWEEK UPDATE: San Fran is up to 6.5-point home chalk in Borgata Sports' NFL Week 16 odds, after opening -5.5. Last week, the Colts were a big need at Borgata, in Philip Rivers' return after five years.

"I don’t expect to have as big of a decision on this game as we did last week with the Colts," Borgata sportsbook director Tom Gable said. "The Colts shocked a lot of bettors, who were more than happy to lay upwards of 13.5 on Seattle last Sunday.

"Indy could have won that game outright, and Rivers did exactly what was needed from him. This week, they aren’t quite as big of an underdog."

Borgata's total nudged from 46 to 46.5.

OPENING ODDS UPDATE: Indianapolis (8-6 SU and ATS) nearly pulled off a huge upset behind just-acquired QB Philip Rivers. The Colts closed as 13-point underdogs at Seattle and led most of the game, but lost 18-16 on a field goal with 18 seconds remaining.

San Francisco (10-4 SU and ATS) has won and covered its last four, though the latest spread-cover was just barely. The Niners topped Tennessee 37-34, cashing as 12.5-point home favorites on a field goal with 1:10 remaining.

San Fran opened -5.5 vs. Indy at The SuperBook, with no movement Sunday night.

"It'll be interesting to see who is under center for Indianapolis next Monday Night. We’ll be Colts fans," SuperBook VP John Murray said.

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In-Progress NFL Week 16 Games

Completed NFL Week 16 Games

New England Patriots vs. Baltimore Ravens Odds

• Opening point spread: Ravens -2.5
• Opening moneyline: Ravens -140/Patriots +120
• Opening total: Over/Under 47.5 points scored
• Time: 8:20 p.m. ET Sunday (NBC)

GAME DAY UPDATE: As kickoff approaches, Baltimore is -3.5 (-105) in BetMGM's NFL Week 16 odds. That's a high point reached late this afternoon, with the line moving from Ravens -3 (-120), after opening -2.5 and spending much of the week at various iterations of -3.

"We'll want the Patriots to cover, but it's pretty close. It's probably 60% Ravens action," BetMGM trading manager Christian Cipollini said.

The total is at 48.5, matching the opener and just off the 49 high point from Saturday evening until this morning. The number spent Monday-Friday at 48.

MIDWEEK UPDATE: The Ravens are laying 3 points at home in Borgata Sports' Week 16 NFL odds. That's up a notch from the Baltimore -2.5 opener.

"I expect this game to toggle back and forth between 2.5 and 3 as we go through the week," Borgata sportsbook director Tom Gable said. "New England comes in here off a loss to Buffalo, in which the Patriots blew a nice lead.

"The Ravens know they need to keep winning, as they remain one game back of the Steelers in the division."

Borgata's total is at 48 from a 48.5 opener.

OPENING ODDS UPDATE: New England (11-3 SU/9-5 ATS) saw its 10-game win streak come to an end in Week 15. The Patriots jumped out to a 21-0 lead vs. Buffalo and was still up 24-7 at halftime. But the Pats then allowed a big comeback and lost 35-31 as 2.5-point home favorites.

Baltimore (7-7 SU/6-8 ATS) halted a two-game hiccup to stay in the hunt for the AFC North title. The Ravens, who two weeks ago lost at home to Cincinnati, avenged that setback with a 24-0 blanking as 3-point road favorites.

Baltimore opened -2.5 vs. New England in The SuperBook's Week 16 NFL odds. The Ravens briefly adjusted to -2.5 (-120) Sunday night, then returned to -2.5 flat.

"It says a lot about the Patriots' power rating that they are only getting 2.5 points in Baltimore on Sunday Night Football. Not much to report action-wise yet. I would expect good two-way," SuperBook vice president John Murray said.

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Pittsburgh Steelers vs. Detroit Lions Odds

• Opening point spread: Lions -6.5
• Opening moneyline: Lions -310/Steelers +260
• Opening total: Over/Under 50.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

GAME DAY UPDATE: With 90 minutes until kickoff, the Lions are -7.5 (-105) in BetMGM's NFL Week 16 odds. Last Sunday, Detroit opened -7 (-105) and briefly dipped to -6.5 (-115) late Monday night, then rebounded to -7. The move to Detroit -7.5 (-105) came this morning.

"A lot of Lions action, probably 70% or so. The book needs the Steelers," BetMGM trading manager Christian Cipollini said.

The total is at 52, the highest on the board today. BetMGM opened at 50.5 and twice backed up to 49.5 early in the week, then rebounded to 52, where the number has been since Tuesday.

MIDWEEK UPDATE: Detroit opened as 7-point home chalk at Borgata Sports, and that's where the number remains Wednesday night.

"It’s been mostly early Detroit money here. Detroit needs to win out in order to have a shot at the playoffs," Borgata sportsbook director Tom Gable said. "The Steelers had a pretty commanding win on Monday Night Football against Miami.

"But they know their division will come down to the final week of the season, when they play Baltimore."

Borgata's total is up to 52 from a 50.5 opener in the NFL odds Week 16 market.

OPENING ODDS UPDATE: Detroit (8-6 SU/7-7 ATS) is now on the outside looking in for the NFC playoffs, after being among the preseason/early-season Super Bowl favorites. In Week 15, the Lions lost a shootout with the L.A. Rams 41-34 catching 6.5 points on the road.

Pittsburgh (7-6 SU/7-5-1 ATS) hopes to keep a leg up on Baltimore in the AFC North. The Steelers first need to get out of Week 15, as they host Miami on Monday night.

Detroit opened as 6.5-point home chalk vs. Pittsburgh in The SuperBook's NFL Week 16 odds. There was no movement Sunday night.

"It’s been all Lions so far, with bets on Detroit at -6 on the lookahead line and -6.5. It looks like we’ll be Steelers fans," SuperBook VP John Murray said.

Las Vegas Raiders vs. Houston Texans Odds

• Opening point spread: Texans -14
• Opening moneyline: Texans -1200/Raiders +750
• Opening total: Over/Under 37.5 points scored
• Time: 4:25 p.m. ET Sunday (CBS)

GAME DAY UPDATE: Houston is laying 14 points in BetMGM's Week 16 NFL odds. Last Sunday, the Texans opened -14.5, and the move to -14 came Friday afternoon.

"We can't get anybody to bet the Raiders, even at +14. The book will need the Raiders," BetMGM trading manager Christian Cipollini said.

The total is up a point today, going from 38 to 38.5/39, after opening at 37.5.

MIDWEEK UPDATE: The Texans spent the first part of the week bouncing between the -14 opener and -14.5 at DraftKings. Houston has been steady at -14.5 since Tuesday afternoon on wild point-spread splits: 70% of bets are on the Texans, while 87% of money is on the Raiders.

As of 2:30 p.m. ET Thursday, DK's total is at 37.5, after opening at 38.5 and toggling a couple times between those two numbers. The Over is seeing 68% of bets/54% of money.

OPENING ODDS UPDATE: Houston (9-5 SU and ATS) is on a well-timed six-game winning streak (5-1 ATS). In Week 15, the Texans easily dispatched Arizona 40-20 giving 10 points at home.

Las Vegas (2-12 SU/5-9 ATS) put a doughnut on the scoreboard while losing its eighth straight game. The Raiders fell at Philly 31-0 catching 12.5 points.

The SuperBook opened Houston as 14-point home chalk vs. Las Vegas, with no movement Sunday night. However, there was a little early toggling on the total, which went from 37.5 to 37, then returned to 37.5.

Jacksonville Jaguars vs. Denver Broncos Odds

• Opening point spread: Broncos -3
• Opening moneyline: Broncos -165/Jaguars +145
• Opening total: Over/Under 43.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

Don't bet on this game without reading VI's Jaguars vs. Broncos Predictions!

GAME DAY UPDATE: BetMGM has been planted at Denver -3.5 (-105) since Friday morning, moving there from -3 (-115). A week ago, the Broncos opened -3 (even).

"It's probably 60% of the action to the Broncos, so the book will want the Jags," BetMGM trading manager Christian Cipollini said.

The total is at 47, reaching that high point Friday after opening at 44.5 and climbing throughout the week. Cipollini said BetMGM will want the Under, per usual.

MIDWEEK UPDATE: Denver is painted to -3 in Borgata Sportsbook's NFL Week 16 odds, with no movement so far.

"It's been mostly recreational money coming in on Denver," Borgata sportsbook director Tom Gable said. "The Broncos have already clinched a playoff spot and are in the driver seat for the AFC West division title.

"But their sights are really on the No. 1 seed for the AFC. I think this game will see good two-way action at 3."

The total is on the move at Borgata, climbing from 44.5 to 46.5.

OPENING ODDS UPDATE: Denver (12-2 SU/6-8 ATS) looked to be in a trouble in the third quarter, down 23-14 and with Green Bay seemingly in control. But the Broncos rallied once again, claiming a 34-26 victory as 1.5-point home pups.

Jacksonville (10-4 SU and ATS) is on a five-game SU and ATS upswing that has it atop the AFC South. In Week 15, the Jaguars thumped the New York Jets 48-20 laying 13.5 points at home.

The Broncos opened as 3-point favorites vs. the Jags in The SuperBook's Week 16 NFL odds. There was no change in the number Sunday night, but Denver briefly adjusted to -3 (-120), then returned to -3 flat.

"This game has way more playoff implications than we thought it would back in the summer," SuperBook vice president John Murray said. "We took some money on Jaguars +3, but nothing that has prompted us to move the line."

The total was on the move, going from 43.5 to 44 in short order, then on to 45.

Atlanta Falcons vs. Arizona Cardinals Odds

• Opening point spread: Falcons -1.5
• Opening moneyline: Falcons -130/Cardinals +110
• Opening total: Over/Under 45.5 points scored
• Time: 4:05 p.m. ET Sunday (FOX)

GAME DAY UPDATE: With kickoff inside an hour, Atlanta just moved from -3 (-102) to -2.5 (-118) in DraftKings' Week 16 NFL odds. The Falcons opened -1.5 (-105), advanced to -2.5 Monday and -3 Wednesday.

Atlanta is drawing 62% of spread bets at DK, but spread money is almost dead even.

The total is at 48.5 (Over -115) and in fact has been at some iteration of 48.5 since Wednesday, after opening at 46.5. The Over is taking 58% of bets/80% of money.

MIDWEEK UPDATE: As of 2:30 p.m. ET Thursday, Atlanta is out to -3 (-105) in DraftKings' NFL Week 16 odds, after opening at -1.5 (-105). Early spread play has the Falcons landing 62% of spread bets/69% of spread dollars.

DraftKings' total is up to 48.5 (Under -115) from a 46.5 opener and 45.5 low point Sunday night. The Over is netting 64% of early bets and 94% of early money.

OPENING ODDS UPDATE: Arizona (3-11 SU/6-8 ATS) has lost six in a row and 11 of its last 12 (5-7 ATS). In Week 15, the Cardinals got rolled at Houston 40-20 as 10-point underdogs.

Atlanta (5-9 SU and ATS) halted a 1-7 SU and ATS nosedive in the Week 15 Thursday night game, and in comeback upset fashion, no less. The Falcons erased a 28-14 fourth-quarter deficit at Tampa Bay, rallying for two TDs and a game-ending field goal to win 29-28 catching 6 points.

Falcons-Cards opened at Atlanta -1.5, with no early movement at The SuperBook.

Tampa Bay Buccaneers vs. Carolina Panthers Odds

• Opening point spread: Buccaneers -2
• Opening moneyline: Buccaneers -145/Panthers +125
• Opening total: Over/Under 46.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

Wagering on this one? First, read up on VI's Buccaneers vs. Panthers Predictions!

GAME DAY UPDATE: With 75 minutes until kickoff, the Buccaneers are -3 (-105) in BetMGM's NFL Week 16 odds. A week ago, Tampa Bay opened -2.5 and backed up to -1.5 in short order. But the Bucs rebounded to -2.5 within an hour and went to -3 (-105) Monday.

It's two-way spread spread play at BetMGM.

"Bucs-Panthers is almost 50/50. A little more Bucs action," BetMGM trading manager Christian Cipollini said.

The total was pinned to 45.5 almost all week, shortly after opening at 46.5. But today has seen two moves, to 45 and 44.5 (Over -115). Still, as Cipollini reiterates every week, with the proliferation of same-game parlays, BetMGM will want a low-scoring game.

MIDWEEK UPDATE: Tampa Bay is -3 (even) in DraftKings' NFL odds Week 16 market. On Sunday night, the Bucs opened -2 and went to -2.5 in relatively short order, then Monday morning advanced to -3.

It's very two-way spread play so far, with ticket count dead even and 53% of dollars on Tampa.

DK's total has been at 46 since late Sunday night, down a tick from the 46.5 opener. The Over is getting 69% of bets, while money is running dead even.

OPENING ODDS UPDATE: Carolina (7-7 SU/8-6 ATS) blew an opportunity to gain the upper hand in the NFC South. The Panthers went to New Orleans as 2.5-point favorites and exited with a 20-17 loss on a final-seconds Saints field goal.

Tampa Bay (7-7 SU/5-9 ATS) has almost completely blown up what was once a promising season. The Bucs were 6-2 SU through eight weeks, but have gone 1-5 SU/0-6 ATS since then, including three outright losses as a favorite.

In the Week 15 Thursday nighter, the Bucs were laying 6 points at home vs. Atlanta and imploded in a 29-28 loss. Tampa blew a 14-point fourth-quarter lead, giving up the final 15 points – two touchdowns, while stopping both 2-point conversion attempts – and a final-seconds field goal.

The SuperBook opened Tampa Bay -2 in NFL Week 16 odds and went to -2.5 Sunday evening.

Los Angeles Chargers vs. Dallas Cowboys Odds

• Opening point spread: Cowboys -1.5
• Opening moneyline: Cowboys -130/Chargers +110
• Opening total: Over/Under 49 points scored
• Time: 1 p.m. ET Sunday (FOX)

GAME DAY UPDATE: Dallas is -1.5 (-105) in BetMGM's NFL odds Week 16 market, as of 11:45 a.m. ET. This morning alone, the Cowboys have toggled between multiple numbers (-1.5/-2/-2.5), after opening -1.5 and spending a good chunk of the week at -2/-2.5.

But interestingly, straight spread action is overwhelmingly on the Chargers.

"We're taking a ton of Chargers money. The book will need the Cowboys," BetMGM trading manager Christian Cipollini said.

The total is at 50.5, after opening and spending most of the week at 49.5. The Over is getting 69% of of tickets/86% of money.

MIDWEEK UPDATE: As of 2 p.m. ET Thursday, the Cowboys are 2.5-point home favorites in DraftKings Sportsbook's Week 16 NFL odds. Dallas has spent the week toggling between -1.5/-2.5, with the most recent move coming Wednesday morning.

The Chargers are seeing 66% of early spread bets/53% of early spread money. Moneyline splits have a similar lean toward Los Angeles.

DraftKings' total is painted to 49.5, sticking there all week. The Over is taking 72% of bets/86% of money.

OPENING ODDS UPDATE: Dallas (6-7-1 SU/7-7 ATS) doesn't even have a thread to hang on for the postseason. In Week 15, the Cowboys were 6-point home favorites vs. Minnesota and lost outright 34-26. Dak Prescott & Co. have a 1% chance to reach the playoffs.

Los Angeles (10-4 SU/8-6 ATS) has won and cashed three in a row and is 6-1 SU in its last seven games. In Week 15, the Chargers ended Kansas City's playoff hopes, winning 16-13 as 6-point road underdogs.

Chargers-Cowboys opened at Dallas -1.5 in The SuperBook's NFL odds Week 16 market., but came off the board once Vikings-Cowboys kicked off. Chargers-Cowboys went back up Monday morning at Dallas -2.

Buffalo Bills vs. Cleveland Browns Odds

• Opening point spread: Bills -10
• Opening moneyline: Bills -550/Browns +425
• Opening total: Over/Under 41.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

GAME DAY UPDATE: As of 10:45 a.m. ET, the Bills are -10.5 (even) at BetMGM. Buffalo opened -10 (-115) last Sunday and have been at -10.5 since Thursday. No surprise, Josh Allen & Co. are netting 77% of spread tickets/80% of spread money in online/mobile action.

BetMGM's total is at 40.5, reaching that low point for the week this morning. The number opened at 41.5 (Over -115) and peaked last Sunday night at 43.5, then slowly made its way down during the week. The Under is seeing 56% of tickets/59% of money.

MIDWEEK UPDATE: The Bills are -10.5 (-105) in DraftKings' NFL Week 16 odds, as of 2 p.m. ET Thursday. That's up a tick from Sunday's -10 (-115) opener.

Despite the double-digit spread, it's all Bills early, with 78% of tickets and money on Buffalo.

DK's total is at 41.5, arriving there Wednesday after opening at 42.5 and initially going up to 43.5. The Over is netting 62% of early tickets, while 83% of early money is on the Under.

OPENING ODDS UPDATE: Buffalo (10-4 SU/7-7 ATS) isn't letting New England waltz away with the AFC East title. The Bills dug themselves into a 21-0 Week 15 hole at Foxboro, but rallied for a 35-31 victory giving 2.5 points to end the Patriots' 10-game win streak.

Cleveland (3-11 SU/5-9 ATS) managed only a third-quarter field goal behind Shedeur Sanders in frigid Chicago. The Browns were 7.5-point 'dogs and got blown out 31-3.

Bills-Browns opened at Buffalo -10 in The SuperBook's Week 16 NFL odds, with no early movement on the spread. But the total climbed from 41.5 to 42, then to 43 Sunday night.

Kansas City Chiefs vs. Tennessee Titans Odds

• Opening point spread: Chiefs -4.5
• Opening moneyline: Chiefs -180/Titans +160
• Opening total: Over/Under 38.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

GAME DAY UPDATE: With Gardner Minshew starting at QB, Kansas City is -3 (-118) on the road in BetMGM's NFL Week 16 odds. The Chiefs opened -4.5 (-115), quickly dropped to -3.5 and went to -3 Wednesday.

This morning, K.C. briefly ticked up to -3.5 (even), before returning to -3. Point-spread betting splits are rather wild, with 55% of tickets and a whopping 94% of cash on the underdog Titans. Moneyline bettors are on Tennessee, too, at 61% of tickets/96% of cash.

"I would've been shocked a few weeks ago to see we are taking more Titans action," BetMGM trading manager Christian Cipollini said, noting the book needs Kansas City, which is without Patrick Mahomes (ACL) for the rest of the season.

BetMGM's total is painted to 37.5, with no movement this week. The Over is taking 56% of tickets/64% of money.

MIDWEEK UPDATE: As you might expect, the loss of Patrick Mahomes is having a huge effect on this point spread. On DraftKings' lookahead line last week, the Chiefs were -10.5. When the game reopened Sunday night, it was at Kansas City -4.5.

Bettors quickly took Titans +4.5 and got this number down to Chiefs -3.5 by late Sunday night. It's now Chiefs -3 (-115), as of 2 p.m. ET Thursday. Tennessee is drawing 59% of early spread bets/82% of early spread money.

DraftKings' total opened at 38.5 and quickly went to 37.5, where it remains. The Over is getting 59% of bets/58% of money.

OPENING ODDS UPDATE: Kansas City (6-8 SU/5-9 ATS) reached the last seven AFC title games, winning five conference titles and three Super Bowls. But the Chiefs will miss the playoffs this season. Worse still, Patrick Mahomes suffered a season-ending ACL tear.

K.C. sealed its fate with a 16-13 loss giving 6 points at home against the L.A. Chargers in Week 15. Mahomes was injured late in the fourth quarter. The Chiefs are 1-5 SU/0-6 ATS in their last six games.

Tennessee (2-12 SU/6-8 ATS) hung around in the first half at San Francisco. But the Titans couldn't keep pace in the second half, losing 37-24 as 12.5-point underdogs.

Last week's lookahead line on Chiefs-Titans was Kansas City -10.5. With no Mahomes, The SuperBook opened K.C. -4.5 and moved to -4 Sunday night, and the total dipped from 38.5 to 37.5.

Cincinnati Bengals vs. Miami Dolphins Odds

• Opening point spread: Dolphins -1.5
• Opening moneyline: Dolphins -125/Bengals +105
• Opening total: Over/Under 50.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

GAME DAY UPDATE: At noon ET, Cincy is -3.5 (-118) in BetMGM's Week 16 NFL odds, having moved off -4 this morning. This line actually opened at Miami -1.5 (-105), but flipped to Cincinnati -1 after the Dolphins' dreadful MNF performance at Pittsburgh.

Then midweek, after Tua Tagovailoa was yanked as Miami's starter, the Bengals stretched to -2.5/-3/-3.5/-4.5, before settling at -4. The Dolphins will start rookie Quinn Ewers at QB. Accordingly, Cincinnati is a popular play.

"This will be one to watch. It's majority Bengals action, and that line moved with the QB switch," BetMGM trading manager Christian Cipollini said.

BetMGM's total is at 48, down from a 50.5 opener, but up from Wednesday's 47 low point. Ticket count is dead even, while 79% of money is on the Over.

MIDWEEK UPDATE: With Tua Tagovailoa getting yanked as the Dolphins' starting QB, this line has seen noteworthy movement. Miami opened -1.5 (-105) at DraftKings, then flipped to Bengals -1.5 after the Dolphins' dreadful effort in a 24-15 loss at Pittsburgh on Monday night.

Cincinnati advanced to -2.5 Tuesday, and after Wednesday's news of Tua's benching, the Bengals shot straight to -4.5 and even -5.5 briefly. As of 2:30 p.m. ET Thursday, it's Cincy -4.5 (-105), with Miami set to start rookie Quinn Ewers.

The Bengals are drawing 66% of early spread bets at DK, but 57% of early spread dollars are on the Dolphins.

DraftKings' total opened at 50.5 and went straight to 47.5 on the Tagovailoa news Wednesday. It's two-way action, with 52% of bets on the Over/57% of cash on the Under.

OPENING ODDS UPDATE: Cincinnati (4-10 SU/6-8 ATS) showed a little life when Joe Burrow returned, beating Baltimore and nearly beating Buffalo, both on the road. But in Week 15, the Bengals had no answer for the Ravens, losing 24-0 as 3-point home pups.

Miami (6-7 SU/7-6 ATS) isn't yet out of Week 15. The Dolphins, on a four-game SU run, visit Pittsburgh on Monday night.

Miami opened -1.5 vs. Cincy in The SuperBook's NFL odds Week 16 market, with no movement Sunday night.

Minnesota Vikings vs. New York Giants Odds

• Opening point spread: Vikings -2.5
• Opening moneyline: Vikings -150/Giants +130
• Opening total: Over/Under 42.5 points scored
• Time: 1 p.m. ET Sunday (FOX)

GAME DAY UPDATE: The Vikes are -2.5 (-115) in BetMGM's NFL odds Week 16 market, two hours before kickoff. Minnesota opened -2.5 (-105) and briefly dipped to -1.5 last Sunday, then spent most of the week at -3 (-105).

Spread betting splits are wildly disparate, with 68% of tickets on the Vikings/86% of money on the Giants. Moneyline splits are similarly wonky, with 61% of tickets on the Vikes/97% of money on Big Blue.

BetMGM's total is at 42, reaching that low point this morning, after opening at 42.5 (Over -115) and peaking at 44 Monday. Still, 62% of bets/70% of dollars are on the Over.

MIDWEEK UPDATE: Minnesota is -3 (-105) in DraftKings' Week 16 NFL odds, as of 2 p.m. ET Thursday. The Vikings went from -1.5 to -2.5 Sunday and have mostly been at some iteration of -3 since Monday afternoon.

Minnesota is seeing 72% of early spread tickets, but 72% of early spread money is on home 'dog New York.

DK's total is at 43.5, matching the opener, though it's toggled to 44.5 a couple times this week. The Over is taking 64% of tickets, but 80% of cash is on the Under.

OPENING ODDS UPDATE: New York (2-12 SU/7-7 ATS) saw its losing streak stretch to eight games in Week 15. The Giants closed as 2.5-point home favorites vs. Washington and lost 29-21.

Minnesota (6-8 SU and ATS) has been a big letdown after going 14-3 SU/11-5-1 ATS in the 2024-25 regular season. But the Vikes got an upset in Week 15 that might just keep Dallas out of the playoffs. The Vikings were 6-point road underdogs and beat the Cowboys 34-26.

Vikings-Giants opened at Minnesota -2.5 in The SuperBook's NFL Week 16 odds, then came off the board once Vikes-Cowboys kicked off. Vikes-Giants went back up Monday morning at Minnesota -2.5 (-120) and quickly advanced to -3.

New York Jets vs. New Orleans Saints Odds

• Opening point spread: Saints -3.5
• Opening moneyline: Saints -210/Jets +180
• Opening total: Over/Under 40.5 points scored
• Time: 1 p.m. ET Sunday (CBS)

GAME DAY UPDATE: New Orleans is out to -6.5 (-105) at BetMGM, as of 11 a.m. ET. Last Sunday, the Saints opened -4.5 (-115), and they initially backtracked to -4 a couple times early in the week. But they climbed to -5.5/-6 Thursday and -6.5 Friday and again this morning.

The Saints are drawing 62% of spread bets and a massive 96% of spread dollars in BetMGM's online/mobile wagering.

The total spent most of the week at various iterations of 40.5, but was at 40 from Monday-Tuesday morning and 41 Tuesday evening. Bettors are favoring the Under, at 58% of tickets/78% of money.

MIDWEEK UPDATE: The Saints are 5.5-point home favorites in DraftKings' NFL Week 16 odds, moving off -4.5 (-115) Thursday afternoon. New Orleans opened at -4.5 (-105) Sunday evening.

The Saints are taking 62% of early spread tickets/74% of early spread money.

DK's total is painted to 40.5, with no movement this week, not even a juice adjustment. The Over is landing 57% of tickets, and 69% of money is on the Under.

OPENING ODDS UPDATE: New Orleans (4-10 SU/6-8 ATS) notched a modest home upset in Week 15, further mucking up the latest edition of Who Wants To Win The NFC South. The Saints, 2.5-point home 'dogs, overcame a 17-7 third-quarter deficit to beat Carolina 20-17 on a final-seconds field goal.

New York (3-11 SU/5-9 ATS) was a 13.5-point underdog at Jacksonville in Week 15, and the game went accordingly. The Jets got flattened 48-20, their fourth loss in the last five games.

The SuperBook opened Jets-Saints at New Orleans -3.5 and moved to -4 within an hour Sunday night.

Green Bay Packers vs. Chicago Bears Odds

• Opening point spread: Packers -3
• Opening moneyline: Packers -125/Bears +105
• Opening total: Over/Under 46.5 points scored
• Time: 8:20 p.m. ET Saturday (FOX)

Before you bet, check out VegasInsider's Packers vs. Bears Predictions!

GAME DAY UPDATE: The Bears are laying a single point at home in BetMGM's NFL Week 16 odds. The Packers actually opened -2.5 (-115) on Sunday and dipped to -1.5 within a couple hours, then went to -1 on Tuesday.

On Thursday, the line jumped the fence to Bears -1/-1.5, then returned to -1 this morning.

"It's split down the middle, maybe a slight lean to the Bears for liability," BetMGM trading manager Tristan Davis said, while noting that parlays stemming from the Eagles-Commanders game will determine tonight's need. "It all depends on what happens in D.C. right now."

The total is down 1.5 points just today, starting at 46.5 and now at 45, with a stop at 45.5 along the way. BetMGM opened the total at 46.5 and got to 47 on Thursday and Friday, before today's back-up. Still, when factoring in same-game parlays and such, the book will want the Under tonight.

MIDWEEK UPDATE: Borgata Sports is down to Green Bay -1 as of 9:30 p.m. ET Wednesday, after opening the Pack at -2.5.

"This is a huge matchup in the NFC North," Borgata sportsbook director Tom Gable said. "The loss of Micah Parsons for the season looms large for Green Bay in its future prospects. But the injury to Christian Watson is also looming over this game."

Watson, the Packers' star wideout, is questionable with chest/shoulder injuries, though he said Wednesday he expects to play.

The total is at 46.5 from a 47 opener at Borgata.

OPENING ODDS UPDATE: Green Bay (9-4-1 SU/6-8 ATS) had its four-game win streak halted in Week 15. The Packers led at Denver 23-14 early in the third quarter, but couldn't hold up in a costly 34-26 setback giving 1.5 points.

Green Bay fell behind Chicago in the NFC North. Further, defensive star Micah Parsons reportedly tore an ACL, which would his season. And standout wideout Christian Watson left in the third quarter with a chest injury.

Chicago (10-4 SU/8-5-1 ATS) rebounded nicely from its Week 14 loss at Green Bay. In extremely cold temperatures, the Bears bashed Cleveland 31-3 as 7.5-point home favorites.

The Bears and Packers just met in Week 14, with Green Bay winning 28-21 as 6.5-point home chalk. This time around, The SuperBook opened the Pack -3, quickly went to -2.5 Sunday night, then settled at -2.

"It's a rematch from the game played just 13 days earlier. I think we’ll end up needing the Bears this time," SuperBook VP John Murray said.

Philadelphia Eagles vs. Washington Commanders Odds

• Opening point spread: Eagles -5.5
• Opening moneyline: Eagles -260/Commanders +220
• Opening total: Over/Under 45 points scored
• Time: 5 p.m. ET Saturday (FOX)

Betting on this matchup? Check out VegasInsider's Eagles vs. Commanders Predictions!

GAME DAY UPDATE: The Eagles are -7 (-118) in BetMGM's NFL odds Week 16 market, 75 minutes before kickoff. On Sunday, Philadelphia opened -6 (-115), then advanced to -6.5 Monday and -7 (-115) Thursday.

"It's straightforward here: We need the Commanders and a low-scoring game," BetMGM trading manager Seamus Magee said. "It's one-way traffic on Philly today.

"And we're hoping we can limit the amount of damage on same-game parlays, including Jalen Hurts/Saquon Barkley and A.J. Brown touchdowns."

Further, moneyline parlays are an issue for the day, including bettors combining College Football Playoff matchups with the NFL. So Washington outright is far better than a Commanders cover.

"That would come in handy, for sure. There are lots of happy BetMGM players with that Miami outright win [vs. Texas A&M]. Commanders outright would be a parlay killer," Magee said.

MIDWEEK UPDATE: Philly is up to a 6.5-point favorite at Borgata Sports, a notch up from the -6 opener in NFL Week 16 odds.

"So far, it’s been all Eagles money," Borgata sportsbook director Tom Gable said, while noting Philadelphia is usually popular at his Atlantic City shop. "The Eagles' easy win over the Raiders on Sunday has quieted the concern slightly here amongst Eagles backers.

"They had a lot of support in that game here. It was one of the bigger decisions of the day, which obviously didn’t go our way."

The total is at 44.5 from a 45.5 opener.

OPENING ODDS UPDATE: Philadelphia (9-5 SU/8-6 ATS) found the cure for a three-game losing streak: Playing the Las Vegas Raiders. In Week 15, the Eagles breezed to a 31-0 victory laying 12.5 points at home.

Washington (4-10 SU/5-9 ATS) halted a season-killing eight game losing streak in Week 14. The Commanders closed as 2.5-point underdogs at the Giants and notched a 29-21 victory.

Philly and Washington met in last season's NFC Championship Game, with the Eagles rumbling to a 55-23 win. Week 16 marks the first meeting of the season for these two, who play again at Washington in Week 18.

Eagles-Commanders opened at Philadelphia -5.5 in The SuperBook's Week 16 NFL odds, and the line went to -6 within an hour Sunday night.

"Philadelphia should be a big public play to start the weekend, with the books needing the Commanders," SuperBook VP John Murray said.

Los Angeles Rams vs. Seattle Seahawks Odds

• Opening point spread: Pick
• Opening moneyline: Seahawks -110/Rams -110
• Opening total: Over/Under 46.5 points scored
• Time: 8:15 p.m. ET Thursday (Prime)

GAME DAY UPDATE: With kickoff an hour out, the Seahawks are -1.5 (-102) in BetMGM's Week 16 NFL odds. On Sunday, the Rams opened -1.5 (even) and on Monday went to -1. The line jumped the fence to Seattle -1/-1.5 Wednesday.

That's in part due to the Rams wideout Davante Adams (14 TDs) out tonight with knee/hamstring injuries.

"It's been mostly Seahawks money all the way through the week, and more so today. At this stage, we are cheering for the Rams outright, a rarity for us," BetMGM trading manager Tristan Davis said.

The total is at 42.5 on what's expected to be a windy night in Seattle. On Sunday, the total opened at 45.5, and it bottomed out at 42 on Wednesday evening. Davis said with parlay play and same-game parlays, BetMGM needs the Under, per usual.

MIDWEEK UPDATE: As of 9:30 p.m. ET Wednesday, the Seahawks are 1.5-point favorites in Borgata Sports' NFL odds Week 16 market. That's a flip from the Rams -1 opener, with a stop at pick along the way.

That said, early action favors Los Angeles.

"So far, the public is backing the Rams here, even with Davante Adams doubtful with a hamstring injury," Borgata sportsbook director Tom Gable said. "He hasn’t been ruled out by the Rams yet.

"With two of the best teams in the entire NFC going head-to-head, in a game that could go a long way to deciding the NFC West, there has been strong advance handle on this game."

The total is down to 42 from a 45.5 opener, with weather potentially an issue Thursday night. Rain is expected during the day, then winds of 10-20 mph Thursday night, with temperatures in the high 30s.

OPENING ODDS UPDATE: Seattle (11-3 SU/10-4 ATS) almost became an immediate victim of Old Man Rivers, narrowly surviving an upset bid in Week 15. The Seahawks needed a 56-yard field goal with 18 seconds remaining to beat Philip Rivers and Indianapolis 18-16.

All of Seattle's points came from the leg of Jason Myers, who made six field goals on the day. The Seahawks fell miles short of cashing as 13-point home favorites, but are still 8-1 SU/7-2 ATS in their last nine games.

Los Angeles is also 11-3 SU/10-4 ATS after holding off the Detroit Lions 41-34 as 6-point home favorites in Week 15. And like the Seahawks, the Rams are 8-1 SU/7-2 ATS in their last nine.

In Week 11 at L.A., the Rams beat the Seahawks 21-19, but Seattle covered as a 3-point pup. And as noted above, these two teams are Nos. 1-2 in Super Bowl 60 odds.

The SuperBook rates this game a toss-up in NFL Week 16 odds.

"We opened it pick, and I don’t see any reason to move for now," SuperBook vice president John Murray said Sunday night. "It looked as if Seattle almost got caught looking ahead to this game today vs. the Colts. But the Seahawks pulled it out in the end.

"The No. 1 seed in the NFC is on the line. We’ll probably be rooting for the Seahawks."

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson