Last Updated Oct 20, 2022, 8:07 PM

New Orleans Saints vs. Arizona Cardinals Picks, Predictions, Odds

Week 7 of the NFL season will kick things off on Thursday night with a compelling NFC showdown between the New Orleans Saints and Arizona Cardinals. Coverage begins from State Farm Stadium in Glendale at 8:15 p.m. ET on Amazon Prime.

NEW ORLEANS SAINTS vs. ARIZONA CARDINALS BETTING PREDICTION

The Saints have been on quite the rollercoaster in their first six contests following the retirement of head coach Sean Payton, as New Orleans averaged 23.5 PPG on 382 YPG across a lackluster 2-4 skid to open the season, with two of those losses coming by narrow margins or four points or less in tough home matchups against the Vikings and Bengals.

The Cardinals, on the other hand, are also off to a frustrating 2-4 start to the season, however, cut them some slack, DeAndre Hopkins served a suspension for the first six weeks and their schedule hasn’t exactly been a walk in the park, as Arizona racked up 27.5 PPG on 376 YPG across a pair of wins over the Raiders and Panthers, and averaged just 14.8 PPG on 331 YPG in losses to the Chiefs, Rams, Seahawks, and Eagles.

I’ll take the over here, as both of these offenses have been up-and-down to start the season, however, I think we’ll see a steady dose of scoring in Thursday’s matchup between a Saints defense that’s allowed 26+ PTS in four-of-six contests (26.3 PPG), and a Cardinals defense that surrendered 23.7 PPG across their first six matchups.

Score Prediction: Cardinals 26, Saints 23
Best Bet: Over 45 (-110)

NEW ORLEANS SAINTS vs. ARIZONA CARDINALS BETTING ODDS

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NEW ORLEANS SAINTS vs. ARIZONA CARDINALS BETTING RESOURCES

Date: Thursday, Oct. 20, 2022
Matchup: NFC South vs. NFC West
Venue: State Farm Stadium
Location: Glendale, Arizona
Time-TV: Amazon Prime, 8:15 p.m. ET

NEW ORLEANS SAINTS BETTING ANALYSIS

The Saints barreled out to a red-hot start with Jameis Winston under center last season, as New Orleans opened with a solid 5-2 run that included tough victories over the Packers, Patriots, and Buccaneers. However, Winston suffered a season-ending knee injury in Week 8, and the Saints went 4-6 the rest of the way.

The Saints are a much different squad in the aftermath of Payton’s retirement, but they still have an embarrassment of riches on the offensive side of the ball. However, talent-level doesn’t matter if you can’t protect the football, as the Saints turned the ball over a league-high 13 times in the first six weeks of the season, and that type of turnover rate is almost always a recipe for disaster, but typically bodes well for over bettors.

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The Saints are 8-3 ATS in their last 11 matchups against Arizona. (Getty Images)

ARIZONA CARDINALS BETTING ANALYSIS

After barreling out to an impressive 10-2 start last year, the Cardinals completely fell apart down the homestretch, as Arizona closed the regular season with a head-scratching 1-4 skid, which included a string of head-scratching losses to the Lions, Colts, and Seahawks. The Cards still managed to secure the top NFC Wild Card spot with a record of 11-6, however, their struggles only got worse in the postseason, as the Rams stomped Arizona by a score of 34-11 in the opening round.

So, compared to last year’s miserable finish, the Cardinals haven’t looked all that bad, especially on the defensive side of the ball. However, Arizona’s offense has now scored 17 PTS or less in three-of-six matchups to open the year (19 PPG), and we’ve come to expect far more from an offense led by Kyler Murray. But they shouldn’t have much trouble moving the ball against a Saints defense that’s surrendered 20+ PTS in all six of their matchups this season (26.3 PPG).

NEW ORLEANS SAINTS vs. ARIZONA CARDINALS BETTING TRENDS

  • The Saints are 2-4 ATS in their last six games.
  • The total has gone OVER in five of New Orleans' last seven games.
  • The Cardinals are 4-8 ATS in their last 12 games.
  • The total has gone UNDER in four of Arizona's last five games.
  • The Cardinals are 3-9 SU in their last 12 games.
  • The Cardinals are 0-8 SU in their last eight home games.
  • The Saints are 1-4 SU in their last five games.
  • The Saints are 8-3 ATS in their last 11 games against Arizona.
  • The Saints are 5-2 SU in their last seven games against Arizona.
  • The Saints are 4-1 SU in their last five road games.
  • The total has gone OVER in six of the last eight matchups between the Cardinals and Saints.
  • The total has gone OVER in four of New Orleans' last five road games against Arizona.
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