College Football Odds Week 1: North Carolina vs South Carolina Lines, Spreads, Betting Trends
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College football odds for Week 1 are on the board and receiving plenty of attention as we tackle all the major storylines of the weekend. The North Carolina Tar Heels and South Carolina Gamecocks meet at Bank of America Stadium in Charlotte on Saturday, September 2 at 7:30 p.m. ET on ABC.
Here's everything you need to know about the college football odds for the Week 1 game between North Carolina and South Carolina: the opening lines, spreads, betting trends and more. Check back regularly for updates.
No. 21 North Carolina vs South Carolina Odds

- Opening point spread: North Carolina -2.5
- Opening moneyline: North Carolina -137/South Carolina +114
- Opening total: Over/Under 63.5 points scored
- Time: 7:30 p.m. ET Saturday (ABC)
UPDATE 4 P.M. ET MONDAY: Finally, a game with a close point spread, after all the mismatches coming up this weekend. And FYI, this is a neutral-site contest, at Bank of America Stadium in Charlotte, N.C.
North Carolina was on fire through 10 games last season, at 9-1 SU and riding a six-game win streak. But the Tar Heels didn't post another W, finishing 9-5 SU/7-7 ATS. In the Holiday Bowl, UNC fell to Oregon 28-27, but covered as a 13-point underdog.
South Carolina lodged one of the bigger upsets of the 2022-23 campaign, stomping Tennessee 63-38 as a hefty 23.5-point home underdog. The Gamecocks finished 8-5 SU/7-6 ATS, including a 45-38 loss as 5-point Gator Bowl pups to Notre Dame.
TwinSpires Sportsbook opened North Carolina -2.5 on Aug. 22. There's been no movement thus far in the college football Week 1 odds market. It's two-way action with a lean toward South Carolina, at 56% of tickets/59% of money.
"The Gamecocks are a trendy 'dog early in the week," Lucas said, before noting the total moving up to 64.5. "Sharp play on Over 63.5."
The Over is netting 58% of early tickets/74% of early dollars.
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