2025 College Football Odds Week 10: Lines, Spreads, Betting Trends on Biggest Games

Patrick Everson Sports Betting Expert

13 minute read

The College Football Odds Week 10 market has a couple of appealing matchups to wrap up the day.

Oklahoma vs. Tennessee is arguably the bigger of the two in college football Week 10 odds. But Cincinnati vs. Utah has big Big 12 ramifications, and perhaps CFP ramifications as well.

Here’s everything you need to know about college football odds Week 10: opening lines, spreads and betting trends for the biggest games, as multiple oddsmakers provide insights on Week 10 college football odds and action. Be sure to check out our staff's list of college football week 10 best bets.

Check back regularly for updates and use our bet365 bonus code to get the most out of your action.

(Feature image: Rob Gray/Imagn Images)

2025 College Football Odds for Week 10

Cincinnati vs. Utah Odds

• Opening point spread: Utah -7
• Opening moneyline: Utah -300/Cincinnati +250
• Opening total: Over/Under 55.5 points scored
• Time: 10:15 p.m. ET Saturday (ESPN)

GAME DAY UPDATE: The Utes are laying 10.5 points at BetMGM, 90 minutes before kickoff. That matches Wednesday's high point, after Utah opened -6.5 and steadily climbed from there.

"Cincy +10 right now is a need. We'll see where the chips fall come kickoff. But so far today, Utah has been taking some decent money," BetMGM trading manager Seamus Magee said.

The total is also at a high point of 57.5 (Over -115), well up from a 54.5 opener.

LATE WEEK UPDATE: As the status of Utah QB Devon Dampier has reportedly improved, this line has climbed at DraftKings. Dampier sat out last week's 53-7 rout of Colorado with a lower-leg injury.

The Utes opened -6.5, quickly advanced to -7 and on Monday went to -7.5/-8.5/-9.5. Utah peaked at -10.5 Wednesday and is -10 (-105) as of 1:30 p.m. ET Thursday. That said, underdog Cincinnati is attracting 79% of early spread bets/59% of early spread money.

Unlike the spread, the total has come down, now at 54.5 from a 56.5 opener. However, 67% of bets/87% of dollars are on the Over.

EARLY WEEK UPDATE: Borgata Sports opened Utah -6.5 and is up to -7.5 in college football Week 10 odds.

"Cincinnati has been one of the best stories in college football this season in my opinion. They are undefeated [in conference play] in an extremely difficult Big 12, with their lone loss of the season coming at the hands of Nebraska in Week 1," Borgata sportsbook director Tom Gable said.

"The Bearcats travel to Utah to face a Utes team with a potent rushing attack, but injury issues at quarterback."

The total is up to 56.5 from a 54.5 total.

"We’ve seen the most action on the total," Gable said.

OPENING ODDS UPDATE: No. 17 Cincinnati (7-1 SU/6-2 ATS) looks to stay in the chase for the Big 12 title and a bid in the CFP. In Week 9, the Bearcats rolled over Baylor 41-20 as 3.5-point home favorites.

No. 24 Utah (6-2 SU and ATS) also still harbors Big 12 championship aspirations, but can't take another loss. In Week 9, the Utes tuned up by plastering Colorado 53-7 as 14-point home faves.

Utah opened as 7-point home chalk in Circa Sports' college football Week 10 odds. There's been no movement in the first few hours Sunday.

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Oklahoma vs. Tennessee Odds

• Opening point spread: Tennessee -3
• Opening moneyline: Tennessee -165/Oklahoma +145
• Opening total: Over/Under 56.5 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

GAME DAY UPDATE: With 45 minutes until kickoff, the Vols are -2.5 (-115) in BetMGM's Week 10 college football odds. Tennessee opened -4 on Sunday and quickly dipped to -3.5, then went to -3 Monday and -2.5 Thursday.

Friday brought a move up to -3 (-105), and the Vols went to the current -2.5 (-115) early this afternoon.

"We're gonna need Oklahoma +2.5 tonight. A ton of money has come in on the Vols today. We'll need Under 55.5, too," BetMGM trading manager Seamus Magee said.

The total is at 55.5 (Under -115), down from a 56.5 opener and 57.5 high point early in the week.

LATE WEEK UPDATE: Tennessee has been at -3 almost all week at DraftKings Sportsbook, after opening -4 and dipping to -3.5 (-115) shortly thereafter on Sunday. The line has been at some iteration of Vols -3 since Monday afternoon and remains there at 1 p.m. ET Thursday.

Spread ticket count is 3/1 and spread money 2.5/1 on Tennessee so far.

The total is at 56.5, matching Sunday's opener, after a brief Sunday stint at 55.5 and a short Wednesday stretch at 57.5. Tickets and money are running 3/1 on the Over.

EARLY WEEK UPDATE: Tennessee opened -4 at home and is down to -3.5 in Borgata Sports' college football Week 10 odds market.

"Some early money on the Sooners pushed this spread down to 3," Borgata sportsbook director Tom Gable said, while noting the total is stable at 56.5.

OPENING ODDS UPDATE: Tennessee (6-2 SU/4-4 ATS) rebounded nicely from its Week 8 loss at Alabama. The Vols pounded Kentucky 56-34 as 7.5-point road favorites.

On the flip side, Oklahoma (6-2 SU/4-4 ATS) lost for the second time in three games. The Sooners closed as 5.5-point home favorites vs. Ole Miss and lost 34-26.

Neither team can afford another SEC loss. Circa Sports opened the Vols -3 and sped to -4.5, then settled at -3.5 by 1:35 p.m. ET Sunday. The total was also a quick mover, from 56.5 down to 55.

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Georgia vs. Florida Odds

• Opening point spread: Georgia -8
• Opening moneyline: Georgia -300/Florida +250
• Opening total: Over/Under 50.5 points scored
• Time: 3:30 p.m. ET Saturday (ABC

GAME DAY UPDATE: BetMGM was pinned to Georgia -7.5 all week, mostly at -105 juice in college football odds Week 10. But the number dipped to Bulldogs -7 (-115) this morning, and BetMGM is now dealing -105 juice on both sides of 7.

"We're gonna need Florida +7. There's plenty of interest in the Bulldogs today. Florida outright would kill a ton of parlays," BetMGM trading manager Seamus Magee said.

The total is at 50.5 (Over -115), after spending all week at 50.5 flat.

MIDWEEK UPDATE: DraftKings has Georgia at -7 (-115) in college football Week 10 odds, where the line has stuck since Monday. The Bulldogs quickly went from their -8.5 opener to 7.5 Sunday, then toggled between -7.5/-7 a couple times before stabilizing Monday evening.

Georgia is getting the big bulk of early spread action, at 82% of tickets/78% of money as of 1 p.m. ET Thursday.

The total is painted to 50.5 at DK, with no movement all week. The Under is getting 63% of tickets, while 68% of cash is on the Over.

EARLY WEEK UPDATE: Georgia opened and remains -7.5 in Borgata Sports' Week 10 college football odds, as of 10 p.m. ET Monday.

"No change to any of the opening numbers here for the cocktail party," Borgata sportsbook director Tom Gable said, noting the total remains 50.5. "Things haven’t gone well for the Gators this season. But this is their chance to make a mark for the season, coming off their bye week.

"The Bulldogs are also coming off a bye. While they only have one loss on the season, to Alabama, they have some challenges remaining on their schedule, with Texas and Georgia Tech a few weeks out.

OPENING ODDS UPDATE: With Florida playing sub-.500 ball, this matchup lacks its usual allure. Still, it's the World's Largest Outdoor Cocktail Party, on neutral turf in Jacksonville, and the Gators would love nothing more than to upset their archrival.

Georgia (6-1 SU/3-4 ATS) had a bye in Week 9 after a big Week 8 victory. The Bulldogs knocked off previously unbeaten Ole Miss 43-35 as 7-point home favorites.

Florida (3-4 SU/2-5 ATS) is also coming off a bye after nearly enduring a home upset vs. Mississippi State. The Gators held on for a 23-21 victory giving 9.5 points. Even with the win, Florida athletic director Scott Stricklin had seen enough this season, firing coach Billy Napier.

Georgia opened -8 in Circa's Week 10 college football odds. That number lasted a short time before dipping to Bulldogs -7.5.

Virginia vs. California Odds

• Opening point spread: Virginia -3
• Opening moneyline: Virginia -185/California +160
• Opening total: Over/Under 54.5 points scored
• Time: 3:45 p.m. ET Saturday (ESPN2)

GAME DAY UPDATE: Virginia is out to -6 (-105) in BetMGM's college football Week 10 odds, having just moved there from -5.5. In fact, it's -105 juice on both sides of -6 now. The Cavaliers opened -4 and moved to -3.5 Monday, then climbed to -5.5 by Thursday.

"Virginia-Cal is getting good, balanced action on both sides. No real need for this game, even on the total," BetMGM trading manager Seamus Magee said.

The total is at 52.5 (Under -115), reaching that low point Thursday after opening 54.5 and spending the first half of the week at 53.5.

LATE WEEK UPDATE: Virginia has spent most of the week bouncing between -4/-4.5 in DraftKings' college football odds Week 10 market. The Cavaliers spent a few hours Monday at -3.5, then rebounded to -4 and went to -4.5 Tuesday evening.

As of 1 p.m. ET Thursday, Virginia is netting 63% of early spread bets, while 61% of early spread money is on home underdog California.

DK's total is at 52.5 from a 54.5 opener, with the number at 53.5 much of the week. The Over is drawing 63% of bets, but 82% of cash is on the Under.

EARLY WEEK UPDATE: As of 10 p.m. ET Monday, Virginia is a 3.5-point road favorite at Borgata Sports. That's down a tick from the opener of Cavaliers -4.

"Virginia found itself in an unexpected tight game with North Carolina, but eventually prevailed in overtime. Now, the Cavaliers travel across the country to face the team everyone thinks of when they think of the ACC, the California Golden Bears," Borgata sportsbook director Tom Gable said with a strong hint of sarcasm.

The Cavs are certainly in the hunt for the ACC title and perhaps a CFP berth.

"Virginia will need to stay undefeated in conference play, which certainly isn’t out of the question with its remaining schedule."

OPENING ODDS UPDATE: At this stage, with the first round of College Football Playoff rankings due out Nov. 4, this report has to include an ACC game. And this one is the best of the Week 10 batch.

Virginia (7-1 SU/5-3 ATS) has somewhat flown under the radar this season, currently on a six-game SU win streak that includes three overtime victories. In Week 9, the Cavaliers edged North Carolina 17-16 by stopping a 2-point attempt in the first overtime.

However, the Cavs fell well short of cashing as 11.5-point road favorites.

California is 5-3 SU (3-5 ATS) but could just as easily be 6-2 SU at this point. In Week 9, the Golden Bears got a late touchdown at Virginia Tech to tie the game at 27 and force overtime. But Cal fell 42-34 in double overtime as a 6.5-point underdog.

Circa Sports opened Virginia -3 in the college football odds Week 10 market. Shortly thereafter Sunday, the Cavaliers advanced to -3.5.

Vanderbilt vs. Texas Odds

• Opening point spread: Texas -3
• Opening moneyline: Texas -138/Vanderbilt +118
• Opening total: Over/Under 45.5 points scored
• Time: Noon ET Saturday (TV TBA)

GAME DAY UPDATE: An hour before kickoff, Texas is -3 (-115) in BetMGM's college football odds Week 10 market. The Longhorns opened -2.5 and initially dipped to -1.5 Monday afternoon.

But the number rebounded to Texas -2.5 Tuesday and has toggled between -2.5/-3 a couple times since then. In BetMGM's digital wagering (mobile/online), spread ticket count is dead even, but 70% of spread money is on Texas.

"It's straightforward for us: Vandy +3 is the need. And Vandy outright kills a lot of parlays, too. It's been one-way traffic on Texas the past two days," BetMGM trading manager Seamus Magee said.

BetMGM's total just hit its high point of 47.5, moving up from 46.5 (Over -115). The number opened at 45.5 and bottomed out at 44.5 Tuesday. Magee said there's not much of a decision.

LATE WEEK UPDATE: The latest move in this matchup just occurred, at 1 p.m. ET Thursday. The Longhorns went from -2.5 (-120) to -3 (-108) in DraftKings Sportsbook's Week 10 college football odds.

Texas opened -2.5 Sunday and made a couple trips early this week to -1.5, before rebounding.

Opinions are split on the point spread, with 62% of early bets on underdog Vanderbilt and 62% of early money on Texas. No surprise, but 73% of moneyline bets are on the Commodores, while moneyline dollars are closer to even.

DK's total has toggled between 45.5/44.5 a few times, at various juice, and it's now 45.5 flat. The Over is seeing 71% of bets, while 59% of money is on the Under.

EARLY WEEK UPDATE: This line is on the move out of the gate in Borgata Sports' college football odds Week 10 market.

"Texas opened as a 2.5-point home favorite, but the early money has all been on Vanderbilt. It is now down to Texas -1.5," Borgata sportsbook director Tom Gable said Monday night. "Texas survived a scare on Saturday, while Vandy had a nice win against a tough Mizzou squad.

"I wouldn’t be surprised to see this matchup close around pick 'em come the weekend. Texas appears to be hanging by a thread with its national title hopes, while Vanderbilt continues to pick up steam every week."

The total nudged from 50.5 to 50.

OPENING ODDS UPDATE: Vanderbilt (7-1 SU/6-2 ATS) continued its surprising season with a barely-got-there Week 9 win. The Commodores topped Missouri 17-10 as 3-point home favorites, stopping a Hail Mary on the 1-yard line to dodge overtime or a potential loss.

Texas (6-2 SU/2-6 ATS) nearly saw its season evaporate, trailing by 17 three times in the second half at Mississippi State, twice in the fourth quarter. But the Longhorns rallied for a 45-38 overtime victory laying 8 points on the road.

Arch Manning suffered a concussion on the first play of OT, so his Week 10 status is unclear at the moment.

Still, Texas opened as a 3-point home favorite in Circa's college football Week 10 odds. That line was a quick mover, too, nudging to Longhorns -2.5 within minutes Sunday.

Penn State vs. Ohio State Odds

• Opening point spread: Ohio State -20
• Opening moneyline: Ohio State -2250/Penn State +1200
• Opening total: Over/Under 43.5 points scored
• Time: Noon ET Saturday (FOX)

GAME DAY UPDATE: Ohio State is down to -17.5 in BetMGM's college football Week 10 odds, with 50 minutes until kickoff. The Buckeyes just moved down from -18.5, after opening -20.5 and hitting -21 early in the week.

Spread bettors are all over Ohio State in BetMGM's digital wagering (mobile/online), at 77% of tickets/88% of money.

"Sharps and the market starting move toward Penn State. But Penn State +18.5 is the need," BetMGM trading manager Seamus Magee said.

The total has been at some iteration of 44.5 since Wednesday, after opening 44.5 and sitting at 43.5 from Sunday night-Wednesday night. It's now 44.5 (Over -115). Magee said there's not much of a decision.

LATE WEEK UPDATE: The Buckeyes are 20.5-point home favorites in DraftKings' college football odds Week 10 market, as of 1 p.m. ET Thursday. That's where the number has been much of the week, save for about 14 hours from Wednesday into Thursday at Ohio State -21 (-105).

It's all Buckeyes early, with spread tickets running 3/1-plus and spread money 6/1.

The total is at 44.5, matching the opener after spending the first half of the week at various iterations of 43.5. Tickets and money are in the 7/1 range on the Over.

EARLY WEEK UPDATE: Ohio State opened as 20.5-point home chalk and briefly got to -21 in Borgata Sports' college football Week 10 odds. As of Monday night, the Buckeyes are back at -20.5.

"Before the season started, this was circled as the Big Ten Game of the Year. Not so much anymore," Borgata sportsbook director Tom Gable said. "Penn State is having one of their more disappointing seasons in recent history after many expected them to challenge for a national title.

"Everything has gone according to plan for Ohio State thus far. As long as the Buckeyes avoid any trip-up spots, they should find themselves firmly in not only the College Football Playoff, but the national title hunt again."

The total opened at 44.5.

"We took respected money right away to the Under, and the total now sits at 43.5," Gable said.

OPENING ODDS UPDATE: Ohio State (7-0 SU/6-1 ATS) remains ranked No. 1 and is coming off a Week 9 bye. In Week 8, the Buckeyes blanked Wisconsin 34-0 laying 24.5 points on the road for their fourth straight spread-cover.

On the flip side, Penn State (3-4 SU/1-6 ATS) has been approved for federal disaster relief funds. It all began with a respectable 30-24 home overtime loss to Oregon in Week 5.

Now, the Nittany Lions are on a four-game purge, during which coach James Franklin was fired. Most recently, Penn State suffered a 25-24 setback at Iowa as 3-point Week 8 underdogs. Like Ohio State, Penn State had a bye in Week 9.

Circa Sports, whose opening numbers often draw early sharp play, pegged Ohio State 20-point home chalk to start. The Buckeyes quickly advanced to -21 by 1:40 p.m. ET Sunday, and the line remains there in the college football odds Week 10 market.

Patrick Everson

Patrick Everson is a senior reporter for VegasInsider. Based in Las Vegas since 1994, he's worked in the sports betting journalism/content space for more than a decade. He's most known for his deep roster of contacts behind sportsbook counters, providing readers and viewers with the ins-and-outs of how events are being bet. He's also a thought leader in the sports betting space, often appearing on or moderating panels at national conferences. More from Patrick Everson