College Football Odds Week 10: Purdue vs Michigan Lines, Spreads, Betting Trends
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Week 10 of the college football season continues with what has the makings of a lopsided Big Ten tilt between Purdue and Michigan. The Boilermakers are listed as huge 32-point underdogs as they seek their third win of the season on a trip to face the second-ranked Wolverines. Coverage begins from Michigan Stadium in Ann Arbor on Saturday, November 4 at 7:30 p.m. ET on NBC.
Here's everything you need to know about the college football odds for Week 10 Purdue vs. Michigan: the opening lines, spreads, betting trends and more. Check back regularly for updates and use our BetMGM bonus code to get the most out of your action.
Purdue vs No. 2 Michigan Odds

- Opening point spread: Michigan -33
- Opening moneyline: Michigan TBA/Purdue TBA
- Opening total: Over/Under 48.5 points scored
- Time: 7:30 p.m. ET Saturday (NBC)
UPDATE 2 P.M. ET FRIDAY: Michigan is nailed to -32.5 at BetMGM, with just a couple of juice moves this week. After opening -32.5 flat, the Wolverines adjusted to -32.5 (-115) Tuesday, then returned to 32.5 flat Thursday.
It's all Michigan on the spread, at 77% of bets/86% of money.
Conversely, the total has seen plenty of movement, climbing from 48.5 to 52.5 by Thursday, with multiple stops along the way. The Over is attracting 71% of bets/88% of money.
UPDATE 3 P.M. ET MONDAY: Michigan is embroiled in an alleged sign-stealing controversy, so a bye in Week 9 was likely welcomed. The Wolverines (8-0 SU/4-3-1 ATS) were 25.5-point road favorites against Michigan State and rolled 49-0 in Week 8.
Purdue (2-6 SU and ATS) went to Nebraska as slim 1.5-point chalk and left with a 31-14 loss.
Michigan is down a half-point to -32.5 at Caesars. The total briefly receded to 48 this morning, then returned to 48.5.
Click here for Vegas Insider senior reporter Patrick Everson's full College Football Odds Week 10 Report containing spreads, lines, and trends for every Top 25 matchup.
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